Prevalence of depressive symptoms and anxiety in osteoarthritis: a systematic review and meta-analysis

Stubbs, Brendon; Aluko, Yetty; Myint, Phyo Kyaw; Smith, Toby

doi:10.1093/ageing/afw001

Cited by 198 publications

(142 citation statements)

References 61 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…A meta-analysis examined prevalent depression among 10,811 adults from 24 studies. The meta-analysis estimated the pooled prevalence at 19.9% [95% Confidence Interval (CI): 15.9–24.5%, I 2 = 96.1%] [122]. In subgroup analyses, the study also estimated prevalent depression by types of OA.…”

Section: Prevalence Of Depression Among Individuals With and Withomentioning

confidence: 99%

Healthcare burden of depression in adults with arthritis

Sambamoorthi

Shah

Zhao

2017

Expert Review of Pharmacoeconomics & Outcomes Research

View full text Add to dashboard Cite

Introduction Arthritis and depression are two of the top disabling conditions. When arthritis and depression exist in the same individual, they can interact with each other negatively and pose a significant healthcare burden on the patients, their families, payers, healthcare systems, and society as a whole. Areas covered The primary objective of this review is to summarize, identify knowledge gaps and discuss the challenges in estimating the healthcare burden of depression among individuals with arthritis. Electronic literature searches were performed on PubMed, Embase, EBSCOhost, Scopus, the Cochrane Library, and Google Scholar to identify relevant studies. Expert Commentary Our review revealed that the prevalence of depression varied depending on the definition of depression, type of arthritis, tools and threshold points used to identify depression, and the country of residence. Depression exacerbated arthritis-related complications as well as pain and was associated with poor health-related quality of life, disability, mortality, and high financial burden. There were significant knowledge gaps in estimates of incident depression rates, depression attributable disability, and healthcare utilization, direct and indirect healthcare costs among individuals with arthritis.

show abstract

Section: Prevalence Of Depression Among Individuals With and Withomentioning

confidence: 99%

Healthcare burden of depression in adults with arthritis

Sambamoorthi

Shah

Zhao

2017

Expert Review of Pharmacoeconomics & Outcomes Research

View full text Add to dashboard Cite

show abstract

“…Depressive symptoms are significant psychological features in a large proportion of the osteoarthritis population. Stubbs et al [38] estimated the prevalence of depressive symptoms in the osteoarthritis population to be 20% (95% CI: 16 to 25%). Given this, and the complex relationship between physical inactivity and depression, consideration to screening and managing depression and the causes of depressive symptoms, may be an important consideration in facilitating physical activity change for people postarthroplasty.…”

Section: Discussionmentioning

confidence: 99%

Trajectory of physical activity following total hip and knee arthroplasty: data from the English Longitudinal Study of Ageing (ELSA) cohort

Smith

Dainty

Macgregor

2017

European Journal of Physiotherapy

Self Cite

View full text Add to dashboard Cite

Purpose: To determine the prevalence and trajectory of physical activity levels in people before and after total hip (THA) and total knee arthroplasty (TKA). Results: There was a statistically significant decrease in physical activity from the pre-arthroplasty phase to the operative-recovery phase (p<0.01), and a significant increase in physical activity from the operative-recovery phase to final follow-up (p=0.05). However, overall there was no significant change in physical activity from pre-operatively to final follow-up where prevalence altered from 8% (95% Confidence Intervals (CI): 5% to 12%) to 13% (95% CI: 9% to 18%)(p=0.15). Increasing age, male gender and greater depressive symptoms were explanatory variables associated with physical inactivity (p<0.02). Materials and Methods Conclusion:Physical activity does not increase following THA or TKA. A proportion of the arthroplasty population remain physically inactive.

show abstract

“…Depressive symptoms are a frequent comorbidity of osteoarthritis (OA), the most common form of arthritis, which affects approximately 27 million Americans [1, 2]. Meta-analysis estimates indicate the point prevalence of depressive symptoms to be 20% among those suffering from OA, which is more than twice the prevalence in the general population [2, 3].…”

Section: Introductionmentioning

confidence: 99%

“…Meta-analysis estimates indicate the point prevalence of depressive symptoms to be 20% among those suffering from OA, which is more than twice the prevalence in the general population [2, 3]. Moreover, depression in OA patients is associated with greater healthcare costs and mortality and decreased quality of life [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Depressive symptoms and structural disease progression in knee osteoarthritis: data from the Osteoarthritis Initiative

et al. 2016

View full text Add to dashboard Cite

Depressive symptoms are associated with increases in pain and functional limitations in knee osteoarthritis (OA). The aim was to determine whether depressive symptoms are also associated with greater structural knee OA progression. Four years of annual radiographic and clinical assessments from the Osteoarthritis Initiative were analyzed. The Center for Epidemiological Studies Depression Scale was used to identify depressive symptoms (threshold = ≥16) at the baseline visit. Propensity scores were used to match participants with and without baseline depressive symptoms on multiple potential confounders. Assessment of radiographic knee OA was based on changes in individual radiographic features, which included osteophyte (OST) grade and joint space narrowing (JSN) grade. Mixed effect models were used to examine structural progression between depressed and non-depressed participants with definitive radiographic knee OA. Depressive symptoms were significantly associated with a higher risk of OST progression (odds ratio [OR] = 1.74; 95% confidence interval [CI]: 1.01, 3.00) and a non-significant lower risk of JSN progression (OR = 0.40; 95% CI: 0.14, 1.15) 1 year after baseline. Conversely, there was a non-significant lower risk of OST progression (OR = 0.71; 95% CI: 0.28, 1.79) and higher risk of JSN progression (OR = 1.89; 95% CI: 0.71, 5.06) from year 3 to year 4 of follow-up. However, the patterns of OST progression and JSN progression were not significantly different between the depressed and non-depressed (P = 0.25 and 0.15, respectively). The findings provide no evidence that depressive symptoms have a detectable effect on changes in radiographic disease severity in knee OA.

show abstract

Prevalence of depressive symptoms and anxiety in osteoarthritis: a systematic review and meta-analysis

Abstract: CRD42013006733.

Cited by 198 publications

References 61 publications

Healthcare burden of depression in adults with arthritis

Healthcare burden of depression in adults with arthritis

Trajectory of physical activity following total hip and knee arthroplasty: data from the English Longitudinal Study of Ageing (ELSA) cohort

Depressive symptoms and structural disease progression in knee osteoarthritis: data from the Osteoarthritis Initiative

Contact Info

Product

Resources

About