Healthcare burden of depression in adults with arthritis

Sambamoorthi, Usha; Shah, Drishti; Zhao, Xiaohui

doi:10.1080/14737167.2017.1281744

Cited by 38 publications

(34 citation statements)

References 175 publications

(169 reference statements)

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“…Similar to previous studies of adults with arthritis overall and for arthritis subtypes (e.g., osteoarthritis or rheumatoid arthritis) ( 2 , 4 , 5 ), the prevalence of anxiety symptoms exceeded that of symptoms of depression. Despite this, adults with anxiety symptoms less commonly reported taking medications for their symptoms than did those with symptoms of depression; the prevalences among those with either anxiety or depression symptoms were not statistically different for speaking with a mental health professional.…”

Section: Discussionsupporting

confidence: 83%

Symptoms of Anxiety and Depression Among Adults with Arthritis — United States, 2015–2017

Guglielmo¹,

Hootman²,

Boring³

et al. 2018

MMWR Morb. Mortal. Wkly. Rep.

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Section: Discussionsupporting

confidence: 83%

Symptoms of Anxiety and Depression Among Adults with Arthritis — United States, 2015–2017

Guglielmo¹,

Hootman²,

Boring³

et al. 2018

MMWR Morb. Mortal. Wkly. Rep.

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“…Lehnert et al( 2011) and Molosankwe et al (2012) found that coexistent depression increased costs of treating diabetes. Sambamoorthi et al (2017) found an increase in costs of treating arthritis when depression coexisted. Baumeister et al (2012) found higher direct, but not indirect costs in the treatment of chronic back pain with comorbid depression.…”

Section: Discussionmentioning

confidence: 99%

The excess costs of depression: a systematic review and meta-analysis

König

Konnopka

2019

Epidemiol Psychiatr Sci

223

143

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Aims Major depressive disorders are highly prevalent in the world population, contribute substantially to the global disease burden and cause high health care expenditures. Information on the economic impact of depression, as provided by cost-of-illness (COI) studies, can support policymakers in the decision-making regarding resource allocation. Although the literature on COI studies of depression has already been reviewed, there is no quantitative estimation of depression excess costs across studies yet. Our aims were to systematically review COI studies of depression with comparison group worldwide and to assess the excess costs of depression in adolescents, adults, elderly, and depression as a comorbidity of a primary somatic disease quantitatively in a meta-analysis. Methods We followed the PRISMA reporting guidelines. PubMed, PsycINFO, NHS EED, and EconLit were searched without limitations until 27/04/2018. English or German full-text peer-reviewed articles that compared mean costs of depressed and non-depressed study participants from a bottom-up approach were included. We only included studies reporting costs for major depressive disorders. Data were pooled using a random-effects model and heterogeneity was assessed with I2 statistic. The primary outcome was ratio of means (RoM) of costs of depressed v. non-depressed study participants, interpretable as the percentage change in mean costs between the groups. Results We screened 12 760 articles by title/abstract, assessed 393 articles in full-text and included 48 articles. The included studies encompassed in total 55 898 depressed and 674 414 non-depressed study participants. Meta-analysis showed that depression was associated with higher direct costs in adolescents (RoM = 2.79 [1.69–4.59], p < 0.0001, I2 = 87%), in adults (RoM = 2.58 [2.01–3.31], p < 0.0001, I2 = 99%), in elderly (RoM = 1.73 [1.47–2.03], p < 0.0001, I2 = 73%) and in participants with comorbid depression (RoM = 1.39 [1.24–1.55], p < 0.0001, I2 = 42%). In addition, we conducted meta-analyses for inpatient, outpatient, medication and emergency costs and a cost category including all other direct cost categories. Meta-analysis of indirect costs showed that depression was associated with higher costs in adults (RoM = 2.28 [1.75–2.98], p < 0.0001, I2 = 74%). Conclusions This work is the first to provide a meta-analysis in a global systematic review of COI studies for depression. Depression was associated with higher costs in all age groups and as comorbidity. Pooled RoM was highest in adolescence and decreased with age. In the subgroup with depression as a comorbidity of a primary somatic disease, pooled RoM was lower as compared to the age subgroups. More evidence in COI studies for depression in adolescence and for indirect costs would be desirable.

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“…Such pain and disabilities associated with RA may contribute to a higher prevalence of depression in individuals with RA compared to healthy controls [ 3 ]. An expert review of depression in arthritis reported that the prevalence of depression in adults with RA can be as high as 66.2% [ 4 ]. A systematic review and meta-analysis of 72 studies estimated the prevalence rate to be 16.8% [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Burden of Depression among Working-Age Adults with Rheumatoid Arthritis

et al. 2018

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Objective This study estimated the excess clinical, humanistic, and economic burden associated with depression among working-age adults with Rheumatoid Arthritis (RA). Methods A retrospective cross-sectional study was conducted among working-age (18 to 64 years) RA patients with depression (N = 647) and without depression (N = 2,015) using data from the nationally representative Medical Expenditure Panel Survey for the years 2009, 2011, 2013, and 2015. Results Overall, 25.8% had depression. In adjusted analyses, adults with RA and depression compared to those without depression were significantly more likely to have pain interference with normal work (severe pain: AOR = 2.22; 95% CI = 1.55, 3.18), functional limitations (AOR = 2.17; 95% CI = 1.61, 2.94), and lower mental health HRQoL scores. Adults with RA and depression had significantly higher annual healthcare expenditures ($14,752 versus 10,541, p < .001) and out-of-pocket spending burden. Adults with RA and depression were more likely to be unemployed and among employed adults, those with depression had a significantly higher number of missed work days annually and higher lost annual wages due to missed work days. Conclusions This study highlights the importance of effectively managing depression in routine clinical practice of RA patients to reduce pain and functional limitations, improve quality of life, and lower direct and indirect healthcare costs.

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Healthcare burden of depression in adults with arthritis

Cited by 38 publications

References 175 publications

Symptoms of Anxiety and Depression Among Adults with Arthritis — United States, 2015–2017

Symptoms of Anxiety and Depression Among Adults with Arthritis — United States, 2015–2017

The excess costs of depression: a systematic review and meta-analysis

Burden of Depression among Working-Age Adults with Rheumatoid Arthritis

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