Prevalence of comorbidities in women with and without breast cancer in Soweto, South Africa: Results from the SABC study

Ayeni, Oluwatosin; Joffe, Maureen; Cubasch, Herbert; Rinaldi, Sabina; Taljaard, Christine; Vorster, Este H; Romieu, Isabelle; Norris, Shane A.

doi:10.7196/samj.2019.v109i4.13465

Cited by 13 publications

(19 citation statements)

References 53 publications

(60 reference statements)

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“…In studies from Sub-Saharan Africa, most of which were conducted in public hospitals from low/middle-income countries with low or unavailable access to breast cancer screening, the proportion of stage III/IV disease was high among HIV-negative patients, as expected [45], but it was slightly higher among WLWH. Unfortunately, only two of those studies provided adjusted ORs for this comparison, taking into account age, race/ethnicity, education, among others, and those ORs were non-significant [11,30]. Thus, it is possible that among this patient population, with an already high baseline proportion of stage III/IV, that the presence of HIV infection does not significantly increase the likelihood of advanced/metastatic breast cancer if adjusted to other clinicopathological characteristics.…”

Section: Discussionmentioning

confidence: 97%

“…The systematic search of literature provided 10,174 unique citations, of which 62 were reviewed as full text (Figure 1). Among them, 20 publications reporting on 18 studies (including 3,174 WLWH [0.13%] and 2,394,598 HIV-negative women [99.87%]) were included: 15 assessed the likelihood of stage III/IV [6,7,[9][10][11]14,17,[24][25][26][27][28][29][30][31], 10 described each stage at diagnosis [6,7,9,14,17,24,25,27,29,31], nine reported on classic subtypes and ER status [7,9,14,17,25,26,29,31,32], four described surrogate subtypes [17,26,29,31] and seven assessed overall survival [14][15][16][17]27,33,34] -Table 1.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Four of the studies were from North America (all from the USA) [10,27,29,33,34] and 14 from Sub-Saharan Africa [6,7,9,11,[14][15][16][17][24][25][26]28,30,31]. Patient inclusion dates spanned from 1996-2018, reflecting the timing of introduction of highly active anti-retroviral treatment.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Impact of HIV infection on baseline characteristics and survival of women with breast cancer

Brandão

Bruzzone

Franzoi

et al. 2020

Aids

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Background: As women living with HIV (WLWH) become older, their risk of developing breast cancer increases. Nonetheless, literature is conflicting regarding tumor stage, distribution of subtypes and overall survival among WLWH vs HIV-negative women with breast cancer. We assessed differences in clinicopathological characteristics and overall survival between these two groups. Methods: Systematic review and meta-analysis using MEDLINE, Scopus, ISI Web of Knowledge, LILACS, SciELO and conference abstracts up to 1/January/2020. Cross-sectional/cohort studies comparing baseline characteristics (stage and/or subtypes) and/or overall survival of WLWH vs HIVnegative women with breast cancer were included. We performed random-effects meta-analyses to estimate summary statistics and subgroup analyses according to region of the world. Results: 18 studies (4 from North America, 14 from Sub-Saharan Africa [SSA]) were included, with 3,174 WLWH and 2,394,598 HIV-negative women. WLWH from North America and SSA were more likely to present with stage III/IV disease compared to HIV-negative womenpooled odds ratio (pOR) 1.76 (95% confidence interval [CI]:1.58-1.95) and pOR 1.23 (95%CI:1.06-1.42), respectively. WLWH from SSA were also less likely to have estrogen receptor-positive/HER2-negative tumors (pOR 0.81; 95%CI:0.66-0.99). After adjustment, WLWH had worse overall survival compared to HIV-negative women, both in North America (pooled adjusted hazard ratio [aHR] 2.45; 95%CI:1.11-5.41) and SSA (aHR 1.43; 95%CI:1.06-1.92). Conclusions: Compared to HIV-negative women, WLWH are diagnosed with breast cancer at a more advanced stage and have a worse overall survival. These results should raise awareness regarding the detection and survival gap among WLWH with breast cancer and further studies are needed to decipher the reasons behind these disparities.

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Section: Discussionmentioning

confidence: 97%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Impact of HIV infection on baseline characteristics and survival of women with breast cancer

Brandão

Bruzzone

Franzoi

et al. 2020

Aids

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“…HIV prevalence was9.2% in adult population above the age of 18 years [ 4 , 14 ]. Most of these chronic conditions share common risk factors with various forms of cancers and as such, positive associations have been reported among them in several studies and these included the following: ageing above 65 years, physical inactivity, alcohol and smoking histories, obesity and urbanization [ 1 , 7 , 9 - 11 , 13 , 15 - 17 ]. Furthermore, comorbid conditions of cancer patients are significantly associated with worse health status during treatment and oncology follow-up periods as well as low or intermediate socioeconomic status, and poor nutritional status [ 7 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Burden of chronic disease comorbidities among cancer patients at Queen Elizabeth and Kamuzu Central Hospitals in Malawi: an exploratory cross-sectional study

Banda¹,

Muula²

2021

Pan Afr Med J

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Introduction chronic disease comorbidities are common among cancer patients in most parts of the world, however; there are limited data on the same for Malawi. Comorbidities worsen clinical outcomes and are associated with lower quality of life among cancer patients. We aimed at estimating chronic disease comorbidities and associated factors among cancer patients attending oncology services at the Queen Elizabeth Hospital (QECH) and Kamuzu Central Hospital (KCH) in Blantyre and Lilongwe respectively. Methods we conducted a cross-sectional study at QECH and KCH in Malawi from January to March 2021. Participants were recruited using simple random sampling technique at the oncology clinics and were interviewed using structured questionnaires. The College of Medicine Research and Ethics Committee (COMREC) approved the study and informed consent was obtained with each participant. Data were analyzed in Stata version 14 and summary statistics were presented as frequencies and proportions. Results we interviewed 398 cancer patients and the mean age was 45.4years (SD± 12.77). The common cancers were cervical (30%), Kaposi´s sarcoma (24%), breast (11%), esophageal (4%) and leukemia (4%). The prevalence of chronic disease comorbidities was 61.56% (n=398) and common conditions included: HIV and AIDS (43%), depression (9%) hypertension (8%) and anemia (9%). Chronic disease comorbidities were significantly associated with formal employment (p<0.01) and obesity (p<0.02). Conclusion chronic disease comorbidities were prevalent among cancer patients in the study settings in Malawi. There is a need to develop a multidisciplinary approach when managing cancer patients with emphasis on active screening for the common conditions as reported by this study.

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“…Much research confirmed the role of diabetes on breast cancer level, increasing hospitalization and decreasing illness-free duration. [33][34][35] Insulin resistance of Type 2 diabetes may cause hyperglycemia that support cell differentiation and proliferation.…”

Section: Association Of Breast Cancer and Diabetesmentioning

confidence: 99%

Investigation of the association between metabolic syndrome and breast cancer patients

et al. 2020

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One of the most serious cancers among women is breast cancer. This disease is the first reason for the death of women due to cancer. Increasing breast cancer risk may associate with many factors including genetic, reproductive factors, people's lifestyle, metabolic syndrome (MS) and hormones. MS has been known as a risk factor for prostate, pancreatic, breast and colorectal cancers. The purpose of this review is to identify the relationship between MS components and breast cancer individually. This study was performed by researching electronic database references including PubMed, Google Scholar, CINAHL ProQuest, and web of science through 2019. The effect of MS with its components and breast cancer was reported in many studies.Nevertheless, a thorough understanding of the mechanisms involved remains a challenge.However, one can take several preventive measures, including a proper diet, which is one of the most important determinants of metabolic status. Also, general preventive recommendations are including reducing alcohol consumption, red meat and total fat in the diet. Moreover, increasing the consumption of vegetable and fruit reduce the proportion of MS patients to improve the outcome of breast cancer patients.

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Prevalence of comorbidities in women with and without breast cancer in Soweto, South Africa: Results from the SABC study

Abstract: This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.

Cited by 13 publications

References 53 publications

Impact of HIV infection on baseline characteristics and survival of women with breast cancer

Impact of HIV infection on baseline characteristics and survival of women with breast cancer

Burden of chronic disease comorbidities among cancer patients at Queen Elizabeth and Kamuzu Central Hospitals in Malawi: an exploratory cross-sectional study

Investigation of the association between metabolic syndrome and breast cancer patients

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