Burden of chronic disease comorbidities among cancer patients at Queen Elizabeth and Kamuzu Central Hospitals in Malawi: an exploratory cross-sectional study

Banda, Jonathan Chiwanda; Muula, Adamson S

doi:10.11604/pamj.2021.40.167.31069

Cited by 4 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,2 In Malawi, in 2021, KS accounted for approximately one-fifth of all cancer cases. 3 Incidence rates are similar in Uganda and other KS-endemic countries. 4,5 In South Africa, KS is the most common cancer in men living with HIV.…”

Section: Introductionmentioning

confidence: 88%

See 1 more Smart Citation

A prospective cohort study identifies two types of HIV+ Kaposi Sarcoma lesions: proliferative and inflammatory

Moorad,

Kasonkanji,

Gumulira

et al. 2023

Intl Journal of Cancer

View full text Add to dashboard Cite

Kaposi sarcoma (KS) is the most common cancer in people living with HIV (PLWH) in many countries where KS‐associated herpesvirus is endemic. Treatment has changed little in 20 years, but the disease presentation has. This prospective cohort study enrolled 122 human immunodeficiency virus (HIV) positive KS patients between 2017 and 2019 in Malawi. Participants were treated with bleomycin, vincristine and combination antiretroviral therapy, the local standard of care. One‐year overall survival was 61%, and progression‐free survival was 58%. The 48‐week complete response rate was 35%. RNAseq (n = 78) differentiated two types of KS lesions, those with marked endothelial characteristics and those enriched in inflammatory transcripts. This suggests that different KS lesions are in different disease states consistent with the known heterogeneous clinical response to treatment. In contrast to earlier cohorts, the plasma HIV viral load of KS patients in our study was highly variable. A total of 25% of participants had no detectable HIV; all had detectable KSHV viral load. Our study affirms that many KS cases today develop in PLWH with well‐controlled HIV infection and that different KS lesions have differing molecular compositions. Further studies are needed to develop predictive biomarkers for this disease.

show abstract

Section: Introductionmentioning

confidence: 88%

“…Kaposi sarcoma (KS) is among the most common cancers in Eastern and Central Africa 1,2 . In Malawi, in 2021, KS accounted for approximately one‐fifth of all cancer cases 3 . Incidence rates are similar in Uganda and other KS‐endemic countries 4,5 .…”

Section: Introductionmentioning

confidence: 99%

A prospective cohort study identifies two types of HIV+ Kaposi Sarcoma lesions: proliferative and inflammatory

Moorad,

Kasonkanji,

Gumulira

et al. 2023

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…The data included cancer diagnosis information for the patient, its stage and treatment options, as well as some known behavioural risk factors and socio-demographic characteristics of the patient. Further details about the project can be found in the article 11 .…”

Section: Methodsmentioning

confidence: 99%

“…For patients with other chronic diseases such as cancer, presence of the diabetes and hypertension diseases is associated with poor prognosis outcomes in the patient 8 – 10 . Therefore, more ways of managing effects of the joint occurrence of diabetes and hypertension in cancer patients have to be explored 11 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bivariate logistic regression model diagnostics applied to analysis of outlier cancer patients with comorbid diabetes and hypertension in Malawi

Kaombe,

Banda,

Hamuza

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The joint occurrence of diabetes and hypertension conditions in a patient is common. The two diseases share a number of risk factors, and are hence usually modelled concurrently using bivariate logistic regression. However, the postestimation assessment for the model, such as analysis of outlier observations, is seldom carried out. In this article, we apply outlier detection methods for multivariate data models to study characteristics of cancer patients with joint outlying diabetes and hypertension outcomes observed from among 398 randomly selected cancer patients at Queen Elizabeth and Kamuzu Central Hospitals in Malawi. We used R software version 4.2.2 to perform the analyses and STATA version 12 for data cleaning. The results showed that one patient was an outlier to the bivariate diabetes and hypertension logit model. The patient had both diabetes and hypertension and was based in rural area of the study population, where it was observed that comorbidity of the two diseases was uncommon. We recommend thorough analysis of outlier patients to comorbid diabetes and hypertension before rolling out interventions for managing the two diseases in cancer patients to avoid misaligned interventions. Future research could perform the applied diagnostic assessments for the bivariate logit model on a wider and larger dataset of the two diseases.

show abstract

Psychological predictors of quality of life among Jordanian cancer patients' caregivers

et al. 2022

View full text Add to dashboard Cite

Objective The caregivers who provide care for patients with cancer often experience emotional and psychological stressors and burdens that could be influenced by several factors, including the cultural context. This study examines the level of emotional distress and burden and their effect on the quality of life (QOL) of Jordanian cancer patients' caregivers. Methods A cross‐sectional survey was conducted among 257 family caregivers of patients at various stages of cancer. Results The average age of caregivers was 37.5 years (SD = 12.2). Most caregivers (145; 59.2%) were female and married (168; 68.6%). About a quarter were partners (32.2%) and lived with their patients (137; 55.9%). Caregivers with a reduced overall Caregiver Quality of Life Index‐Cancer (CQOLC) score were more likely to be older, the parents of the patients, and living with patients in the same house. A significant negative relationship was found between caregivers' CQOLC and Zarit Burden Interview (r = −0.7, p = 0.001), anxiety (r = −0.69, p = 0.001), and depression (r = −0.42, p = 0.03) scores. Multiple linear regression analysis revealed that burden, anxiety, and depression scores were independent predictors and explained 63% of the variance in the total CQOLC score of caregivers. Conclusion Cancer caregivers are at elevated risk of poor QOL. Despite participants' low perception of the burden level, this study provides preliminary results for policymakers and medical practitioners to foster a comprehensive platform supporting cancer caregivers. Moreover, identifying the caregivers' readiness to provide the needed care and the availability of supportive resources, as a clinical routine, is strongly recommended.

show abstract

Burden of chronic disease comorbidities among cancer patients at Queen Elizabeth and Kamuzu Central Hospitals in Malawi: an exploratory cross-sectional study

Cited by 4 publications

References 16 publications

A prospective cohort study identifies two types of HIV+ Kaposi Sarcoma lesions: proliferative and inflammatory

A prospective cohort study identifies two types of HIV+ Kaposi Sarcoma lesions: proliferative and inflammatory

Bivariate logistic regression model diagnostics applied to analysis of outlier cancer patients with comorbid diabetes and hypertension in Malawi

Psychological predictors of quality of life among Jordanian cancer patients' caregivers

Contact Info

Product

Resources

About