Investigation of the association between metabolic syndrome and breast cancer patients

Eskandari, Delaram; Khodabandehloo, Niloofar; Gholami, Abbas; Samadanifard, Hosein; Hejrati, Alireza

doi:10.4081/ejtm.2019.8776

Cited by 7 publications

(4 citation statements)

References 85 publications

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“…Autophagy seems to be a tumor suppressor in carcinogenesis. This is most likely due to a decrease in molecules required for cellular metabolism and proliferation, which finally leads to cell death activation (Eskandari et al, 2020). As a result, a malfunction or loss of several genes involved in the autophagy pathway is linked to carcinogenesis and tumor development (Kardideh et al, 2019; Lin et al, 2017).…”

Section: The Role Of Autophagy In Lung Cancermentioning

confidence: 99%

The roles, controversies, and combination therapies of autophagy in lung cancer

Wang

Zhou

Yang

2021

Cell Biology International

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Lung cancer is one of the leading causes of death among men and women worldwide. The disease initially has a silent phenotype, which leads to the progression of the disease and ultimately the lack of proper response to routine treatments. Autophagy, known as an intracellular “recycle bin” for the degradation of defective proteins and molecules, is one of the mechanisms that has been considered in the context of cancer in recent years. This study aims to provide a comprehensive review of published articles on autophagy in the context of lung cancer to have a complete view of the role of autophagy in lung cancer and its possible treatments. PubMed, Scopus, and Google Scholar were searched until June 15 to find related articles. No specific search filters or restrictions were applied. The results were entered into reference management software for aggregation and management. The full text of all articles was screened and studied. In conclusion, studies on the exact function of autophagy in lung cancer are contradictory, but what can be concluded from a review of literature on lung cancer is that targeting autophagy combined with traditional routine therapies such as chemotherapy, especially in advanced stages of lung cancer, can be an effective anticancer approach.

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Section: The Role Of Autophagy In Lung Cancermentioning

confidence: 99%

The roles, controversies, and combination therapies of autophagy in lung cancer

Wang

Zhou

Yang

2021

Cell Biology International

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“…It covers laboratory tests and anthropometric measurements. MetS was used to stand for metabolic disorders in most clinical studies [28][29][30][31], due to MetS' representativeness, practicability and centrality. Other factors of metabolic disorders which are not included in MetS were rarely studied, but some of these plain indices may be good outcome predictors for CRC.…”

Section: Introductionmentioning

confidence: 99%

Prediction of the incidence of colorectal cancer by routine laboratory tests and anthropometric measurements about metabolism

Cheng

Han

Wan

et al. 2023

Preprint

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Objective To investigate the relationship between metabolic disorders and the morbidity of colorectal cancer (CRC) compared with colorectal adenoma (CRA) and non-neoplastic inpatients, especially to investigate which anthropometric measures were better predictors of CRC. Methods 80 patients with CRC, 80 patients with CRA and 80 non-neoplastic patients were selected from April 2017 to April 2019. The data of routine laboratory tests and anthropometric measurements about metabolism were analyzed retrospectively. Multinomial Logistic regression analysis was used to estimated odds ratio (OR) and 95% confidence interval (CI) for the risk of morbidity of CRC associated with potential risk factors. Results Compared with CRA, OR of CRC was enhanced by weight loss self-reported, lower-hemoglobin and hypoproteinemia. Compared with non-neoplastic controls, diabetes, higher waist-neck ratio (WNR) and The Metabolic syndrome (MetS) identifified by the Chinese Diabetes Society was associated with signifificant increasing risk of all CRC patients. while in male subgroup, OR of CRC was enhanced by diabetes, higher hip circumference, waist-neck ratio (WNR)>2.42 (OR = 2.795, 95%CI: 1.169-6.680), waist-height ratio (WHtR)>0.550 (OR = 3.009, 95%CI: 1.260-7.185) and MetS. In female subgroup, only waist-hip ratio (WHR)>0.890 (multivariable-adjusted OR = 3.354, 95%CI: 1.011-11.129) was significantly associated with increased risk of CRC compared with colorectal adenoma and non-neoplastic controls. The risk factors for CRA were similar to CRC compared with non-neoplastic controls. Conclusion Abdominal fat patients have a high incidence of CRC and CRA. For male, MetS, high level WNR and WHtR caused an increasing risk for CRC. For female, Only WHR is a high-risk factor. The patients with these high risk factors need to strengthen colorectal cancer screening, which is of great significance for the prevention and early detection of colorectal cancer.

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“…[ 16 17 18 19 20 ] The diagnostic criterion for this disorder is high serum concentration (5.06 mIU/L ≥ TSH) with normal serum FT4 level (0.95 to 1.60 ng/d in men and 0.89 to 1.50 ng/d in women). [ 2 21 22 23 ] Subclinical hypothyroidism is associated with a vascular endothelial dysfunction, which may lead to neuropathy due to poor function of small blood vessels.…”

Section: Introductionmentioning

confidence: 99%

Relationship between subclinical hypothyroidism and distal-symmetric diabetic polyneuropathy in type 2 diabetes mellitus referred to Kosar Hospital in Semnan and related indicators in 2019–2020

Foroutan¹,

Reshdat²,

Mehri³

et al. 2022

Journal of Family Medicine and Primary Care

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Introduction: Diabetes is one of the most common metabolic diseases and one of its important complications is diabetic neuropathy. Due to the relationship between diabetes and thyroid disorders, the present study was performed to determine the association between subclinical hypothyroidism and end-stage diabetic polyneuropathy in patients with type 2 diabetes. Materials and Methods: In this descriptive, analytical study, 154 patients with type 2 diabetes referred to Kosar Hospital in Semnan were evaluated. After recording their demographic information, samples were received for biochemical testing. The patients’ neuropathy was then evaluated based on the United Kingdom screening test (UKST). The results were recorded in the data collection form and then analyzed using SPSS Statistics 22 software. Results: In this study, 154 patients were studied, including 49 with subclinical hypothyroidism and 105 with euthyroid. The results of the present study showed that the mean age of patients in the subclinical hypothyroid group was 60.08 years and in the euthyroid group was 60.77 years. Mean ± standard deviation (SD) of the patients’ age, blood pressure, duration of diabetes, body mass index, fasting blood sugar (FBS) and Glucose, and 2-hour post prandial (2HPP) were not statistically significant between the two groups. The frequency of neuropathy severity based on clinical signs during examination and symptoms mentioned by the patients in the two groups was statistically significant ( P = 0.005 and P = 0.001, respectively). The severity of neuropathy was not significantly associated with thyroid-stimulating hormone (TSH) levels ( P > 0.05). Conclusion: From the results of the present study, it can be concluded that the severity of neuropathy based on the clinical signs during examination and the symptoms mentioned by the patient in diabetic patients is related to subclinical hypothyroidism. Further studies are recommended.

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Investigation of the association between metabolic syndrome and breast cancer patients

Cited by 7 publications

References 85 publications

The roles, controversies, and combination therapies of autophagy in lung cancer

The roles, controversies, and combination therapies of autophagy in lung cancer

Prediction of the incidence of colorectal cancer by routine laboratory tests and anthropometric measurements about metabolism

Relationship between subclinical hypothyroidism and distal-symmetric diabetic polyneuropathy in type 2 diabetes mellitus referred to Kosar Hospital in Semnan and related indicators in 2019–2020

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