Prevalence of community‐acquired methicillin‐resistant <i><scp>S</scp>taphylococcus aureus</i> and antibiotic resistance in patients with atopic dermatitis in <scp>P</scp>orto <scp>A</scp>legre, <scp>Brazil</scp>

Petry, Vanessa; Lipnharski, Caroline; Bessa, Giancarlo Rezende; Silveira, Vera B.; Weber, Magda Blessmann; Bonamigo, Renan Rangel; d’Azevedo, Pedro Alves

doi:10.1111/ijd.12020

Cited by 25 publications

(19 citation statements)

References 32 publications

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“…In the current study, CA-MRSA was detected in 28 out of 54 patients colonized with S. aureus, while Hwang et al (2017) in Korea found that 39.4% of AD were colonized by MRSA. A lower percentage of MRSA among S. aureus isolates ranged from 0 to 16% in other reports (Petry et al 2014;Balma-Mena et al 2011;Suh et al 2008). This difference in the prevalence of S. aureus in AD patients might be due to variable methods of sampling, intermittent colonization, and the hygienic status of patients.…”

Section: Discussionmentioning

confidence: 69%

Community-acquired methicillin-resistant Staphylococcus aureus colonization in atopic dermatitis patients in Mansoura, Egypt

2019

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Background: Atopic dermatitis (AD) patients are more frequently colonized with Staphylococcus aureus. The aim of this study is to determine the prevalence of community-acquired methicillin-resistant S. aureus (CA-MRSA) colonization in AD patients in a dermatology clinic in Mansoura, Egypt, and to assess the resistance pattern and the superantigen genes among isolated strains. Methods: Sixty AD patients were evaluated for the carriage of CA-MRSA in both lesional skin and nose. Antimicrobial susceptibility tests were performed using the disc diffusion method. The detection of mecA gene and superantigen genes, toxic shock syndrome toxin (tsst), and staphylococcal enterotoxin sea-sed were done by PCR. Results: Twenty-eight patients (46.7%) were colonized with CA-MRSA. All isolates were sensitive to vancomycin. Only 9.7% of isolates were resistant to ciprofloxacin, while 52.6% of isolates were resistant to fusidic acid and 48.4% were resistant to erythromycin. The predominant toxin gene found in AD patients was tsst that found in 100% of isolates of CA-MRSA, while seb and sed genes found only in 61.2% of the isolates. Conclusion: Atopic dermatitis patients were colonized with CA-MRSA. The most common toxin gene in the Egyptian AD patients was tsst. There is no significant association between any of superantigen genes and severity of AD.

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Section: Discussionmentioning

confidence: 69%

Community-acquired methicillin-resistant Staphylococcus aureus colonization in atopic dermatitis patients in Mansoura, Egypt

2019

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“…It is well known that S. aureus colonizes skin in 60%–100% of AD patients as compared to 5%–30% of healthy controls 910111213. Moreover, 10%–30% of S. aureus isolated from AD patients shows methicillin-resistant S. aureus (MRSA), although there are variations according to areas and the prevalence of MRSA infection is increasing 131415161718. In this review, we discuss S .…”

Section: Introductionmentioning

confidence: 99%

Interactions Between Atopic Dermatitis and Staphylococcus aureus Infection: Clinical Implications

Kim

Ahn

et al. 2019

Allergy Asthma Immunol Res

114

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Staphylococcus aureus commonly colonizes the skin of atopic dermatitis (AD) patients and contributes to the development and exacerbation of AD. Multiple factors are associated with colonization of AD skin by S. aureus , including the strength of S. aureus -corneocyte adhesion, deficiency of antimicrobial peptides, decreased levels of filaggrin and filaggrin degradation products, overexpressed Th2/Th17 cytokines, microbial dysbiosis and altered lipid profiles. S. aureus colonization on AD skin causes skin barrier dysfunction through virulence factors such as superantigens (toxins), enzymes and other proteins. Furthermore, colonization of AD skin by S. aureus exacerbates AD and may contribute to microbial dysbiosis, allergen sensitization, Th2/Th17 polarization, development of atopic march and food allergy in AD patients. Skin colonization of S. aureus , particularly methicillin-resistant S. aureus (MRSA), is one of the major challenges commonly encountered in the management of AD. Bleach bath, and topical or systemic antibiotics could be used to control S. aureus infection on AD skin. However, careful use of antibiotics is required to control the occurence of MRSA. Recently, various strategies, including microbiome transplant, monoclonal antibodies against virulent toxins, vaccines and recombinant phage endolysin, have been studied to control S. aureus infection on AD skin. Further advances in our understanding of S. aureus could provide us with ways to manage S. aureus colonization more effectively in AD patients.

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“…In patients with AD, the prevalence of colonization of the skin and/or nose by S. aureus varies from 60 to 100 %, while in control subjects without AD it varies from 5 to 30 %. A correlation between bacterial colonization and severity of eczema has also been reported in the literature [ 61 ]. Some toxins produced by S. aureus act as superantigens: they are able to produce a massive activation of T cells and contribute to exacerbation of skin lesions.…”

Section: Topical Therapiesmentioning

confidence: 75%

Consensus Conference on Clinical Management of pediatric Atopic Dermatitis

et al. 2016

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The Italian Consensus Conference on clinical management of atopic dermatitis in children reflects the best and most recent scientific evidence, with the aim to provide specialists with a useful tool for managing this common, but complex clinical condition. Thanks to the contribution of experts in the field and members of the Italian Society of Pediatric Allergology and Immunology (SIAIP) and the Italian Society of Pediatric Dermatology (SIDerP), this Consensus statement integrates the basic principles of the most recent guidelines for the management of atopic dermatitis to facilitate a practical approach to the disease. The therapeutical approach should be adapted to the clinical severity and requires a tailored strategy to ensure good compliance by children and their parents. In this Consensus, levels and models of intervention are also enriched by the Italian experience to facilitate a practical approach to the disease.

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Prevalence of community‐acquired methicillin‐resistant Staphylococcus aureus and antibiotic resistance in patients with atopic dermatitis in Porto Alegre, Brazil

Cited by 25 publications

References 32 publications

Community-acquired methicillin-resistant Staphylococcus aureus colonization in atopic dermatitis patients in Mansoura, Egypt

Community-acquired methicillin-resistant Staphylococcus aureus colonization in atopic dermatitis patients in Mansoura, Egypt

Interactions Between Atopic Dermatitis and Staphylococcus aureus Infection: Clinical Implications

Consensus Conference on Clinical Management of pediatric Atopic Dermatitis

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