Prevalence of Antibodies to Hepatitis C Virus among Hemodialysis Patients in Damascus, Syria

Othman, Basem; Monem, Fawza

doi:10.1007/s15010-001-9156-7

Cited by 38 publications

(38 citation statements)

References 22 publications

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“…We found that younger age, history of transplant and history of past HBV infection were associated with HCV infection (19,30,31). Contrary to reported literature, the time on dialysis in our study was not significantly associated with HCV infection (19,30,(32)(33)(34)(35). No data were available on transfusion history or lifestyle behaviours, including substance abuse, which are known to be risk factors for HCV infection (19,25,30,32,34,35).…”

Section: Figure 1) Flow Chart Of Hepatitis C Virus (Hcv) Test Resultscontrasting

confidence: 99%

Prevalence and Incidence of Hepatitis C Virus in Hemodialysis Patients in British Columbia: Follow‐up after a Possible Breach in Hemodialysis Machines

Buxton

Whitlock

et al. 2008

Canadian Journal of Infectious Diseases and Medical Microbiolog

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BACKGROUND: A possible breach of the transducer protector in specific dialysis machines was reported in June 2004 in British Columbia (BC), which led to testing of hemodialysis patients for hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV. This testing provided an opportunity to examine HCV incidence, prevalence and coinfection with HBV and HIV, and to compare anti-HCV and HCV polymerase chain reaction (PCR).METHODS: The results of hemodialysis patients who were dialyzed on the implicated machines (65% of BC dialysis patients), and tested for HCV, HBV and HIV, between June 1, 2004, and December 31, 2004, were reviewed and compared with available previous results.RESULTS: Of 1286 hemodialysis patients with anti-HCV and/or HCV-PCR testing, 69 (5.4%) tested positive. Two HCV genotype 4 seroconversions were identified. HCV incidence rate on dialysis was 78.8 cases per 100,000 person-years. Younger age, history of renal transplant and past HBV infection were associated with HCV infection. No occult infection was identified using HCV-PCR.INTERPRETATION: Hemodialysis patients had three times the HCV prevalence rate of the general BC population, and more than 20 times the incident rate of the general Canadian population. One of the two seroconversions occurred before the testing campaign; the patient was likely infected during hemodialysis in South Asia. The other was plausibly a late seroconversion following renal transplant in South Asia. Nosocomial transmission cannot be ruled out because both patients were dialyzed in the same centre. Baseline and annual anti-HCV testing is recommended. HCV-PCR should be considered at baseline for persons with HCV risk factors, and for returning travellers who received dialysis in HCV-endemic countries to identify HCV infection occurring outside the hemodialysis unit.

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Section: Figure 1) Flow Chart Of Hepatitis C Virus (Hcv) Test Resultscontrasting

confidence: 99%

Prevalence and Incidence of Hepatitis C Virus in Hemodialysis Patients in British Columbia: Follow‐up after a Possible Breach in Hemodialysis Machines

Buxton

Whitlock

et al. 2008

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…The prevalence of anti-HCV antibody in our study was found to be (41.10%) and ranged from (26.05%) to (62.82%) according to the dialysis center (Table: 1) and ( Figure: 1), these results in accordance with that reported by others (Khalaf et al, 1996;Mohammed, 1997;Othman and Monem, 2001;and Al-Shohaib et al, 2003). HCV prevalence in haemodialysis patients is highly variable between different countries and between different centers in the same locality (Devesa et al, 1997).…”

Section: Prevalence Of Anti-hcv Antibodysupporting

confidence: 92%

Hepatitis C Virus Prevalence in Haemodialysis Patients From Three Centers in Baghdad, Iraq: A Survey By Polymerase Chain Reaction and Serological Methods

Abdullah¹,

Ahmed²,

Latif

2014

SJUOZ

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Abstract:Hepatitis C virus infection is a major health problem among haemodialysis patients in developing countries. Nosocomial transmission of HCV infection was a considerable route, particularly during the outbreaks of infection. To compare serological and molecular methods for detection of HCV infection serum samples were screened for anti-HCV antibodies using a fourth generation enzyme-linked immunosorbent assay (ELISA) and positive samples were confirmed by immunoblot assay. All seropositive and seronegative samples were screened for the presence of HCV-RNA by using reverse transcriptase PCR (RT-PCR). The overall prevalence was (41.10%) in the three centers (range: 26.05% to 62.82%) with higher prevalence in Al-Kadhimiya Teaching Hospital. All seropositive samples were tested by reverse transcriptase PCR, and 24/92 (26.09%) of confirmed samples were found to contain HCV-RNA. Additionally, 2/5 (40%) of immunoblot-indeterminate and 1/3 (33.33%) of immunoblot-negative samples were also found to be HCV-RNA positive. Also all seronegative samples were screened for the presence of HCV-RNA by using pooling strategy and 2/136 (1.47%) of anti-HCV negative samples were found to be HCV-RNA positive. Our data emphasize the need for stricter adherence to infection control measures in haemodialysis centers and reinforce the importance of screening by both PCR and serological methods at regular intervals to identify all HCV-infected patients.

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“…Recent data from Indonesia, Syria, and Jordan revealed rates of 63.4%, 48.9% and 34.6%, respectively (Othman & Monem 2001, Bdour 2002, Chanpong et al 2002. In Brazil, anti-HCV prevalence ranges from 20.3% to 64.7% (Vanderborght et al 1995, Carneiro et al 2001, Santana et al 2001, Busek et al 2002.…”

Section: Discussionmentioning

confidence: 99%

[No Title Available]

Souza

Luz²,

Teles

et al. 2003

Mem. Inst. Oswaldo Cruz

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Prevalence of Antibodies to Hepatitis C Virus among Hemodialysis Patients in Damascus, Syria

Cited by 38 publications

References 22 publications

Prevalence and Incidence of Hepatitis C Virus in Hemodialysis Patients in British Columbia: Follow‐up after a Possible Breach in Hemodialysis Machines

Prevalence and Incidence of Hepatitis C Virus in Hemodialysis Patients in British Columbia: Follow‐up after a Possible Breach in Hemodialysis Machines

Hepatitis C Virus Prevalence in Haemodialysis Patients From Three Centers in Baghdad, Iraq: A Survey By Polymerase Chain Reaction and Serological Methods

[No Title Available]

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