Prevalence of antibiotics and antibiotic resistance genes in a wastewater effluent-receiving river in the Netherlands

Sabri, N.A.; Schmitt, Heike; Zaan, Bas van der; Gerritsen, H.W.; Zuidema, T.; Rijnaarts, H.H.M.; Langenhoff, Alette

doi:10.1016/j.jece.2018.03.004

Cited by 252 publications

(115 citation statements)

References 86 publications

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“…Hence, strategies for improving water quality are urgently required. Increase in the distribution of ARB, ARGs, and antibiotics in freshwater has frequently been allied to the discharge of effluents of WWTP as well as other factors including the increase in population density, industrial activities, and agricultural activities along with the courses of freshwater bodies (Sabri et al, 2018). In South Africa, Adefisoye and Okoh (2016) and Igwaran, Iweriebor, and Okoh (2018) detected antibiotic-resistant pathogenic strains of E. coli harboring ARGs including strA, aadA (aminoglycosides); catI, cmlA1 (phenicols); bla TEM (beta-lactamase); tetA, tetB, tetC, tetD, tetK, tetM (tetracyclines), and mcr-1 (colistin); ermA (macrolide), respectively, in final effluents of WWTPs, which is to be discharged into freshwater bodies.…”

Section: Freshwater Bodiesmentioning

confidence: 99%

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

2020

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The agricultural ecosystem creates a platform for the development and dissemination of antimicrobial resistance, which is promoted by the indiscriminate use of antibiotics in the veterinary, agricultural, and medical sectors. This results in the selective pressure for the intrinsic and extrinsic development of the antimicrobial resistance phenomenon, especially within the aquaculture‐animal‐manure‐soil‐water‐plant nexus. The existence of antimicrobial resistance in the environment has been well documented in the literature. However, the possible transmission routes of antimicrobial agents, their resistance genes, and naturally selected antibiotic‐resistant bacteria within and between the various niches of the agricultural environment and humans remain poorly understood. This study, therefore, outlines an overview of the discovery and development of commonly used antibiotics; the timeline of resistance development; transmission routes of antimicrobial resistance in the agro‐ecosystem; detection methods of environmental antimicrobial resistance determinants; factors involved in the evolution and transmission of antibiotic resistance in the environment and the agro‐ecosystem; and possible ways to curtail the menace of antimicrobial resistance.

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Section: Freshwater Bodiesmentioning

confidence: 99%

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

2020

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“…Non-activated titanium disks (Ti) showed the typical grit-blasting topography (Figure 2a(i)), while the samples treated with sodium hydroxide (Ti-N) exhibited a sodium titanate microporous-structure with a representative pore diameter around 1 µm (Figure 2a(ii)) [18][19][20]. Moreover, silanization with TESPSA did not reveal any effect onto the modified titanium morphology (data not shown).…”

Section: Physico-chemical Characterizationmentioning

confidence: 99%

“…Biofilms are hardly accessible for drugs and the host defense system due to its secreted protective layer consisting of extracellular DNA, proteins, and polysaccharides. In addition, the steadily increasing use of antibiotics in recent decades have led to the emergence of antibiotic resistant bacteria (ARB) [18,19]. Importantly, according to a review commissioned by the United Kingdom government, antimicrobial resistance (AMR) will lead to the death of 10 million people a year by 2050 [20].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of Triethoxysilylpropyl Succinic Anhydride Silane (TESPSA) on Titanium Dental Implants

et al. 2020

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Infections related to dental implants are a common complication that can ultimately lead to implant failure, and thereby carries significant health and economic costs. In order to ward off these infections, this paper explores the immobilization of triethoxysilylpropyl succinic anhydride (TESPSA, TSP) silane onto dental implants, and the interaction of two distinct monospecies biofilms and an oral plaque with the coated titanium samples. To this end, titanium disks from prior machining were first activated by a NaOH treatment and further functionalized with TESPSA silane. A porous sodium titanate surface was observed by scanning electron microscopy and X-ray photoelectron spectroscopy analyses confirmed the presence of TESPSA on the titanium samples (8.4% for Ti–N-TSP). Furthermore, a lactate dehydrogenase assay concluded that TESPSA did not have a negative effect on the viability of human fibroblasts. Importantly, the in vitro effect of modified surfaces against Streptococcus sanguinis, Lactobacillus salivarius and oral plaque were studied using a viable bacterial adhesion assay. A significant reduction was achieved in all cases but, as expected, with different effectiveness against simple mono-species biofilm (ratio dead/live of 0.4) and complete oral biofilm (ratio dead/live of 0.6). Nevertheless, this approach holds a great potential to provide dental implants with antimicrobial properties.

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“…Even at relatively low concentration levels (ng to low µg/L or g) in recipient waters and sediments, antibiotics are considered potentially hazardous for the aquatic biota, impacting their survival behavior and fostering the development of antibiotic resistance genes (Gullberg et al 2014;Wang et al 2014;Liu et al 2018). For example, bacteria isolated from sewage bioreactors have exhibited resistance to some antibiotics, including trimethoprim (TMP), erythromycin (ERY), and TETR (Costanzo et al 2005); and antibioticresistant bacteria have been detected in sediments of rivers that have been contaminated with antibiotics (Sabri et al 2018). Antibiotic-resistant bacteria may also be found in the sludge that may eventually be used as a fertilizer on agricultural fields (Kümmerer 2009).…”

Section: Introductionmentioning

confidence: 99%

Occurrence of Antibiotics in Influent and Effluent from 3 Major Wastewater‐Treatment Plants in Finland

Kortesmäki

Östman

Meierjohann

et al. 2020

Enviro Toxic and Chemistry

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Wastewater‐treatment plants (WWTPs) are regarded as one of the main sources of antibiotics in the environment. In the present study, the concentrations of multiple antibiotics and their metabolites belonging to 5 antibiotic classes were determined in 3 major Finnish WWTPs. An online solid phase extraction–liquid chromatography–tandem mass spectrometry method was used for the extraction and analysis of the compounds. The method was fully validated using real and synthetic wastewaters. Seven antibiotics and 3 metabolites were found in the analyzed samples. Sulfonamides were removed most efficiently, whereas macrolides usually showed negative removal efficiency during the treatment, which means that the concentrations for individual antibiotics determined in the effluent samples were higher than in the influent samples. Sulfadiazine was found at concentrations up to 1018 ng/L, which was the highest concentration of any of the detected antibiotics in influent. In the effluent samples, the highest mean concentration was found for trimethoprim (532 ng/L). The measured mass loads of the antibiotics and metabolites to the receiving waters ranged from 2 to 157 mg/d per 1000 population equivalent. The evaluated environmental risk assessment showed that clarithromycin and erythromycin might pose a risk to the environment. The present study further underlines the importance of implementing technology for efficient removal of xenobiotics during wastewater treatment. Environ Toxicol Chem 2020;39:1774–1789. © 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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Prevalence of antibiotics and antibiotic resistance genes in a wastewater effluent-receiving river in the Netherlands

Cited by 252 publications

References 86 publications

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

The incidence of antibiotic resistance within and beyond the agricultural ecosystem: A concern for public health

Antibacterial Properties of Triethoxysilylpropyl Succinic Anhydride Silane (TESPSA) on Titanium Dental Implants

Occurrence of Antibiotics in Influent and Effluent from 3 Major Wastewater‐Treatment Plants in Finland

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