Antibacterial Properties of Triethoxysilylpropyl Succinic Anhydride Silane (TESPSA) on Titanium Dental Implants

Buxadera‐Palomero, Judit; Godoy-Gallardo, María; Molmeneu, Meritxell; Punset, Miquel; Gil, F.J.

doi:10.3390/polym12040773

Cited by 21 publications

(22 citation statements)

References 55 publications

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“…Despite the high success rate of titanium dental implants even higher than 95% at 10 years of implantation [34], lack of osseointegration and bacterial infection can lead to device failure [35][36][37][38][39]. Consequently, there is a strong need to develop new strategies to combat biofilm-related implant infections in order to improve the long-term implant success rate [40][41][42], without necessarily resorting to the use of systemic antibiotic prophylaxis to prevent antibiotic resistant bacteria (ARB) related problems [43][44][45].…”

Section: Introductionmentioning

confidence: 99%

Citric Acid in the Passivation of Titanium Dental Implants: Corrosion Resistance and Bactericide Behavior

et al. 2022

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The passivation of titanium dental implants is performed in order to clean the surface and obtain a thin layer of protective oxide (TiO2) on the surface of the material in order to improve its behavior against corrosion and prevent the release of ions into the physiological environment. The most common chemical agent for the passivation process is hydrochloric acid (HCl), and in this work we intend to determine the capacity of citric acid as a passivating and bactericidal agent. Discs of commercially pure titanium (c.p.Ti) grade 4 were used with different treatments: control (Ctr), passivated by HCl, passivated by citric acid at 20% at different immersion times (20, 30, and 40 min) and a higher concentration of citric acid (40%) for 20 min. Physical-chemical characterization of all of the treated surfaces has been carried out by scanning electronic microscopy (SEM), confocal microscopy, and the ‘Sessile Drop’ technique in order to obtain information about different parameters (topography, elemental composition, roughness, wettability, and surface energy) that are relevant to understand the biological response of the material. In order to evaluate the corrosion behavior of the different treatments under physiological conditions, open circuit potential and potentiodynamic tests have been carried out. Additionally, ion release tests were realized by means of ICP-MS. The antibacterial behavior has been evaluated by performing bacterial adhesion tests, in which two strains have been used: Pseudomonas aeruginosa (Gram–) and Streptococcus sanguinis (Gram+). After the adhesion test, a bacterial viability study has been carried out (‘Life and Death’) and the number of colony-forming units has been calculated with SEM images. The results obtained show that the passivation with citric acid improves the hydrophilic character, corrosion resistance, and presents a bactericide character in comparison with the HCl treatment. The increasing of citric acid concentration improves the bactericide effect but decreases the corrosion resistance parameters. Ion release levels at high citric acid concentrations increase very significantly. The effect of the immersion times studied do not present an effect on the properties.

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Section: Introductionmentioning

confidence: 99%

Citric Acid in the Passivation of Titanium Dental Implants: Corrosion Resistance and Bactericide Behavior

et al. 2022

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“…Silane is commonly used to induce surface modifications through a process designated as silanization, which allows the covalent attachment of various molecules (peptides, polymers, or proteins, for example) to the titanium surface [ 9 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Antibiofilm Coating of Dental Implants—Past and New Perspectives

Esteves

Resende

et al. 2022

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Regarded as one of the best solutions to replace missing teeth in the oral cavity, dental implants have been the focus of plenty of studies and research in the past few years. Antimicrobial coatings are a promising solution to control and prevent bacterial infections that compromise the success of dental implants. In the last few years, new materials that prevent biofilm adhesion to the surface of titanium implants have been reported, ranging from improved methods to already established coating surfaces. The purpose of this review is to present the developed antimicrobial and antibiofilm coatings that may have the potential to reduce bacterial infections and improve the success rate of titanium dental implants. All referred coating surfaces showed high antimicrobial properties with effectiveness in biofilm control, while maintaining implant biocompatibility. We expect that by combining the use of oligonucleotide probes as a covering material with novel peri-implant adjuvant therapies, we will be able to avoid the downsides of other covering materials (such as antibiotic resistance), prevent bacterial infections, and raise the success rate of dental implants. The existing knowledge on the optimal coating material for dental implants is limited, and further research is needed before more definitive conclusions can be drawn.

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“…A significant reduction was obtained in all cases but, as expected, there was a difference in effectiveness between samples against simple mono-species biofilm (ratio dead/live of 0.4) and complete oral biofilm (ratio dead/live of 0.6). Nevertheless, this approach still has a great potential to provide antibacterial properties to dental implant [ 84 , 85 ].…”

Section: Self-assembled Monolayers (Sams)mentioning

confidence: 99%

Bioactive Coatings on Titanium: A Review on Hydroxylation, Self-Assembled Monolayers (SAMs) and Surface Modification Strategies

et al. 2021

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Titanium (Ti) and its alloys have been demonstrated over the last decades to play an important role as inert materials in the field of orthopedic and dental implants. Nevertheless, with the widespread use of Ti, implant-associated rejection issues have arisen. To overcome these problems, antibacterial properties, fast and adequate osseointegration and long-term stability are essential features. Indeed, surface modification is currently presented as a versatile strategy for developing Ti coatings with all these challenging requirements and achieve a successful performance of the implant. Numerous approaches have been investigated to obtain stable and well-organized Ti coatings that promote the tailoring of surface chemical functionalization regardless of the geometry and shape of the implant. However, among all the approaches available in the literature to functionalize the Ti surface, a promising strategy is the combination of surface pre-activation treatments typically followed by the development of intermediate anchoring layers (self-assembled monolayers, SAMs) that serve as the supporting linkage of a final active layer. Therefore, this paper aims to review the latest approaches in the biomedical area to obtain bioactive coatings onto Ti surfaces with a special focus on (i) the most employed methods for Ti surface hydroxylation, (ii) SAMs-mediated active coatings development, and (iii) the latest advances in active agent immobilization and polymeric coatings for controlled release on Ti surfaces.

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Antibacterial Properties of Triethoxysilylpropyl Succinic Anhydride Silane (TESPSA) on Titanium Dental Implants

Cited by 21 publications

References 55 publications

Citric Acid in the Passivation of Titanium Dental Implants: Corrosion Resistance and Bactericide Behavior

Citric Acid in the Passivation of Titanium Dental Implants: Corrosion Resistance and Bactericide Behavior

Antimicrobial and Antibiofilm Coating of Dental Implants—Past and New Perspectives

Bioactive Coatings on Titanium: A Review on Hydroxylation, Self-Assembled Monolayers (SAMs) and Surface Modification Strategies

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