Prevalence of anemia and its associated factors in human immuno deficiency virus infected adult individuals in Ethiopia. A systematic review and meta-analysis

Negesse, Ayenew; Getaneh, Temesgen; Temesgen, Habtamu; Geremew, Tesfahun Taddege; Jara, Dube; Abebaw, Zeleke

doi:10.1186/s12878-018-0127-y

Cited by 16 publications

(46 citation statements)

References 37 publications

(55 reference statements)

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“…Moreover, being female, having WHO clinical stage III or IV, having a BMI less than 18.5 kg/m 2 , having had an opportunistic infection, and taking AZT-containing ART drugs have significant associations with anemia. The magnitude of anemia found in this study is consistent with the findings of a systemic review of Ethiopia, which found the magnitude to be 31.0%; 27 a study conducted in Gondar, North West Ethiopia (22.4%); 28 and a study conducted in South Africa (25.8%). 5 This study's findings were lower than those of studies conducted in different health facilities in Ethiopia: Arba Minch (52.3%); 13 Dire Dawa (41.2%); 6 and Tikur Anbessa Specialized Hospital (34.6%).…”

Section: Discussionsupporting

confidence: 89%

“…This finding is in line with study reports from Malawi, 35 South Africa, 5 and Ethiopia. 6,27 Lower BMI reflect undernutrition as a result of low calorie intake, poor absorption, or poor utilization of nutrients, which leads to insufficient levels of iron, folate, and vitamin B-12 for erythrocyte production. In addition, having a lower BMI increases the risk of infections, which can contribute to the occurrence of anemia.…”

Section: Discussionmentioning

confidence: 99%

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<p>Anemia and Associated Factors Among Adults with Human Immune Deficiency Virus on Antiretroviral Therapy in Public Health Facilities of Kembata Tembaro Zone, Southern Ethiopia: A Cross-Sectional Study</p>

Mengistu¹,

Egata²,

Hawulte³

et al. 2020

HIV

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Background Anemia is an independent prognostic marker of HIV/AIDS disease progression. It causes impaired physical functioning, psychological distress, poor quality-of-life, and reduces life expectancy in HIV patients. However, there is limited information in Ethiopia. Therefore, the aim of this study was to assess the magnitude of anemia and associated factors among adult HIV patients on antiretroviral therapy in public health facilities of Kembata Tembaro Zone, southern Ethiopia. Methods We conducted a facility-based cross-sectional study. A total of 401 HIV patients attending antiretroviral therapy nested in five health facilities were included in the analysis. Simple random sampling was employed using medical record number to select study units. Data were collected using pretested and structured questionnaire, anthropometric measurements were taken, and a drop of capillary blood was collected to determine hemoglobin level by HemoCue 301 analyzer. Clinical related data were collected from patient medical records by using a structured checklist. The collected data were coded and entered into EpiData version 3.1 and exported to SPSS version 20 for analysis. Logistic regression analysis was carried out to identify factors associated with anemia and statistical tests were declared significant at a P -value<0.05. Results The magnitude of anemia among adults HIV patients attending ART was 26.2%, 95% CI=21.7–30.4. Being female (AOR=2.06, 95% CI=1.02–4.16), body mass index <18.5 Kg/m 2 (AOR=2.28, 95% CI=1.09–4.78), Zidovudine use (AOR=3.71, 95% CI=1.9–7.26), having had an opportunistic infection (AOR=5.46, 95% CI=1.67–17.7), and WHO stage III or IV (AOR=5.71, 95% C=2.68–12.14) were significantly associated with the occurrence of anemia. Conclusion Anemia was found to be a moderate public health problem among ART attendants in the current study area. Thus, early detection and intervention targeting Zidovudine users, females, patients having body mass index <18.5 Kg/m 2 , patients having opportunistic infections, and patients having clinical WHO stage III or IV disease is vital to reduce the magnitude of anemia and its consequences.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

<p>Anemia and Associated Factors Among Adults with Human Immune Deficiency Virus on Antiretroviral Therapy in Public Health Facilities of Kembata Tembaro Zone, Southern Ethiopia: A Cross-Sectional Study</p>

Mengistu¹,

Egata²,

Hawulte³

et al. 2020

HIV

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“…These search terms were pre-defined to allow a comprehensive search strategy that included all fields within records and Medical Subject Headings (MeSH terms), in order to expand the search in an advanced PubMed search (Appendix). Following the search protocol described by Negesse et al [22], we also used Boolean operator in our search as they outline in their paper: “within each axis we combined keywords with the ‘OR’ operator and we then linked the search strategies for the two axes with the ‘AND’ operator to search studies conducted specifically for each region in the country”. Electronic database searches were conducted from September 1, 2018 to November 10, 2018.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of goiter among children in Ethiopia and associated factors: a systematic review and meta-analysis

et al. 2019

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Background: The distribution of goiter among children and its risk factors are not well investigated in Ethiopia. Therefore, this systematic review and meta-analysis was designed to determine the pooled prevalence of goiter and its associated factors among children in Ethiopia. Methods: Electronic web-based searches of PubMed, Google Scholar, EMBASE, and the World Health Organization's Hinari portal (which includes the SCOPUS, African Index Medicus, and African Journals Online databases) were conducted to find primary studies. Relevant data were extracted and descriptive summaries of the studies were presented in tables. The I 2 statistic was used to assess heterogeneity across studies. Funnel plot asymmetry and Egger's tests were used to check for publication bias. A random effects model was used to estimate the pooled prevalence of goiter. Odds ratios (OR) with 95% Confidence Intervals (CI) were also used to determine the association of identified variables with goiter. All statistical analyses were conducted using Stata version 14 software. Results: Our search identified 982 studies, of which, 19 articles were eligible for inclusion in the final meta-analysis. The pooled estimate of goiter among children in Ethiopia was 40.50% (95% CI: 33.6-47.40). The regional distribution of goiter ranged from 44.22 (95% CI: 17.44-71) in Southern Nations Nationalities and Peoples' Region, to 32.79% (95% CI: 19.86-45.73) in Benishangul Gumez region. The prevalence of goiter among female children (44.34%) was higher than among male (32.88%) children. Goiter prevalence was also significantly higher among children who consumed vegetables three or more times per week OR = 1.3 (95% CI: 1.02-1.66); those who had family history of goiter, OR = 2.38 (95% CI: 1.9-2.99); and those whose family stored salt near to fires, OR = 1.4 l (95% CI: 1.1-1.79). Conclusion: The prevalence of goiter among children in Ethiopia was high, and endemic according to the WHO criteria. Our findings suggest the need for interventions to improve salt iodization, and for improved health education on appropriate salt storage. In addition, more research may be needed to improve our understanding of foods that increase the risk of goiter among children.

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“…Studies suggest that cytopenias especially anemia1, 8 , 11 , 14 – 25 (prevalence ranging from 1.3% to 95% globally, 21 and 23.9% to 38.0% (31.0% pooled) in Ethiopia 19 before or at the start of highly active antiretroviral therapy (HAART)) would frequently occur in HIV-1 infected patients, mainly during advanced stages of the disease. The occurrence and magnitude of these hematologic abnormalities are likely dependent on the level of viral replication, associated with worsening of the clinical conditions in late-stage AIDS patients with high-level viremia.…”

Section: Introductionmentioning

confidence: 99%

Hematological parameters abnormalities and associated factors in HIV-positive adults before and after highly active antiretroviral treatment in Goba Referral Hospital, southeast Ethiopia: A cross-sectional study

et al. 2021

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Objectives: Hematological abnormalities of the major blood cell lines are frequently reported in patients with HIV-1 infection, in patients without antiretroviral therapy, and during the advanced stages of the disease. Chronic immune activation and inflammation results in the progressive depletion of CD4+ T-cells play a significant role in the clinical progression and pathogenesis of this infection. This study was aimed at assessing the prevalence of hematological abnormalities and their associated factors before and after the initiation of antiretroviral therapy in adults with HIV-1 infection in a referral hospital. Methods: The study was conducted from 1 April to 30 June 2018, at Goba Referral Hospital. A total of 308 HIV-positive adults on treatment were enrolled during the study period. Socio-demographic and clinical data were collected using a structured questionnaire, with pre-highly active antiretroviral therapy data were extracted from medical records while post-treatment immuno-hematological measurements were done on blood samples collected at the time of enrollment. Results: The prevalence of anemia, leukopenia, and thrombocytopenia before initiation of antiretroviral treatment was higher, although anemia and thrombocytopenia decreased correspondingly after initiation of treatment leukopenia increased by 4%. Mean values of immuno-hematological parameters before and after treatment initiation were significant ( p < 0.05). CD4+ T-cell count <200 cells/µL was the only independent risk factor for anemia and leukopenia before highly active antiretroviral therapy, while stage IV disease, female sex, zidovudine, lamivudine, and nevirapine treatment, and intestinal parasite infection were predictors of anemia after treatment initiation. Conclusion: The study revealed that hematological abnormalities are common in HIV infection, while the occurrence of abnormalities after highly active antiretroviral therapy initiation. Different risk factors are associated with hematological abnormalities at pre- and post-highly active antiretroviral therapy with regular monitoring of risk factors, adherence to the early initiation of highly active antiretroviral therapy, and conduct of further longitudinal studies are recommended.

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Prevalence of anemia and its associated factors in human immuno deficiency virus infected adult individuals in Ethiopia. A systematic review and meta-analysis

Cited by 16 publications

References 37 publications

<p>Anemia and Associated Factors Among Adults with Human Immune Deficiency Virus on Antiretroviral Therapy in Public Health Facilities of Kembata Tembaro Zone, Southern Ethiopia: A Cross-Sectional Study</p>

<p>Anemia and Associated Factors Among Adults with Human Immune Deficiency Virus on Antiretroviral Therapy in Public Health Facilities of Kembata Tembaro Zone, Southern Ethiopia: A Cross-Sectional Study</p>

Prevalence of goiter among children in Ethiopia and associated factors: a systematic review and meta-analysis

Hematological parameters abnormalities and associated factors in HIV-positive adults before and after highly active antiretroviral treatment in Goba Referral Hospital, southeast Ethiopia: A cross-sectional study

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