Prevalence of Alleles Associated with HIV Resistance in Russia

Ryabov, Grigory S.; Kazennova, Elena; Bobkova, Marina; Bobkov, Aleksei

doi:10.1089/109065704323016067

Cited by 10 publications

(8 citation statements)

References 19 publications

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“…Genotypic frequency of CCR2-64I observed in our study group (18.2%) is in accordance with that reported in South Indians (3-17%) (Ramana et al, 2001). This mutant allele is present in relatively higher frequencies (11-25%) in the Southeast Asian population (Apostolakis et al, 2005;Lewandowska et al, 2002;Martinson et al, 2000;Royo et al, 2001;Ryabov et al, 2004;Su et al, 1999) (Table 3). The CCR2-64I mutation even in its heterozygous state is reported to be associated with delayed progression to AIDS, thus contributing to the genetic resistance of the HIV-1 infected population developing AIDS (Kostrikis et al, 1998;Martin et al, 1998;Mulherin et al, 2003;Smith et al, 1997a,b).…”

Section: Discussionsupporting

confidence: 91%

“…The global, ethnic and regional distribution of these HIV/AIDS protective mutation frequencies varies significantly giving each population a different genetic resistance profile to the HIV infection and AIDS progression (Apostolakis et al, 2005;Lewandowska et al, 2002;Libert et al, 1998;Martinson et al, 2000;Royo et al, 2001;Ryabov et al, 2004;Su et al, 1999). Among Asian Indians, only a single study conducted on South Indians is reported till date for all the three mutations (Ramana et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Distribution of CCR5Δ32, CCR2-64I and SDF1-3′A and plasma levels of SDF-1 in HIV-1 seronegative North Indians

Verma

Gupta

Singh

et al. 2007

Journal of Clinical Virology

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Distribution of CCR5Δ32, CCR2-64I and SDF1-3′A and plasma levels of SDF-1 in HIV-1 seronegative North Indians

Verma

Gupta

Singh

et al. 2007

Journal of Clinical Virology

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“…The binding epitope of antibodies which neutralize a wide spectrum of HIV isolates has been identified as the third hypervariable loop (V3 loop) of gp120. This region is a surface accessible loop formed by a disulfide bridge between two conserved cysteines at positions 303 and 338 of gp120 and has been shown to bind to the chemokine co-receptors [36][37][38][39][40][41]. Its amino acid sequence varies highly among individual isolates and determines the cellular tropism, thus co-receptor specificity of the virus.…”

Section: Gp120 V3 Peptide-ccr5 Mediated Deregulation Of T Lymphocyte mentioning

confidence: 99%

Conformational Properties of HIV-1 gp120/V3 Immunogenic Domains

Galanakis

Spyroulias²,

Rizos³

et al. 2005

CMC

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Infection of target host cells by the human immunodeficiency virus-1 (HIV-1) is a multi-step process involving a series of conformational changes in the viral gp120 and gp41 proteins. Gp120 binding to the main cell receptor, CD4, on the surface of cells expressing this molecule, and interaction with the cell chemokine receptors CCR5 and CXCR4, are among the key events for HIV-1 infection. These steps are crucial for the virus and offer potential therapeutic targets. For this reason, understanding the structure and the physicochemical characteristics of the gp120 in relation to these interactions has drawn much attention. This review article focuses on the biologically important V3 region of the gp120 and summarizes the functional role, the sequence variation and the conformational features of V3 peptides, which are important for co-receptor selectivity, specificity and interaction. Synthetic V3 peptides have been extensively studied by NMR spectroscopy and X-ray crystallography, in solution or in solid state, in their free or bound form, and valuable information was generated with the aim to be exploited in the design of new, effective inhibitors of HIV-1 infection. The features of the potential gp120 interacting sites on the two chemokine co-receptors, CCR5 and CXCR4, are also discussed, and co-receptor blocking molecules under clinical trial are also reported.

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“…One of such factors is the genetic resistance caused by 32 bp deletion in CCR5 gene can have the effect on limitation of infection. In Europe the prevalence of 32 bp deletion in the human β-chemokine receptor gene is ranked between 16% in the North Europe to 4% in the South Europe [15][16][17][18][19][20][21][22][23][24][25]. In Poland the frequency of deletion was assessed at 10.9% [26].…”

Section: Discussionmentioning

confidence: 99%

The Occurrence of HIV-1 Resistance Biomarker Among Two Cohorts from Poland

Siekierzyńska¹,

Myszka²,

Slęzak³

et al. 2011

J Mol Biomark Diagn

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Approximately 1% of the Caucasians shows resistance to HIV-1 infection conditioned by 32bp deletion in CCR5 gene. Homozygotes are almost totally resistant, but heterozygotes have delay the progression to AIDS. Due to the constantly increase of HIV infection in Poland we examined the incidence of del32 allele in two cohorts (south-western and south-eastern region of country) that remarkably differs in the incidence of HIV. Among the individuals from the south-western region, we detected 7 homozygotes (2.6%), in compare with individuals from the south-eastern area of Poland, where we found 1 homozygote (0.4%). The prevalence of CCR5del32 allele in the group from the southwestern region was estimated at 11.6%, while in the group from the south-eastern region was assessed at 9.7%. Differences in the prevalence of genotypes and alleles between regions were not statistically significant. Our results were discussed in relation to the incidence of HIV infection in Poland. We conclude that occurence of CCR5del32 biomarker does not reflect the incidence of HIV in the examined regions.

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Prevalence of Alleles Associated with HIV Resistance in Russia

Cited by 10 publications

References 19 publications

Distribution of CCR5Δ32, CCR2-64I and SDF1-3′A and plasma levels of SDF-1 in HIV-1 seronegative North Indians

Distribution of CCR5Δ32, CCR2-64I and SDF1-3′A and plasma levels of SDF-1 in HIV-1 seronegative North Indians

Conformational Properties of HIV-1 gp120/V3 Immunogenic Domains

The Occurrence of HIV-1 Resistance Biomarker Among Two Cohorts from Poland

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