The Occurrence of HIV-1 Resistance Biomarker Among Two Cohorts from Poland

Abstract

Approximately 1% of the Caucasians shows resistance to HIV-1 infection conditioned by 32bp deletion in CCR5 gene. Homozygotes are almost totally resistant, but heterozygotes have delay the progression to AIDS. Due to the constantly increase of HIV infection in Poland we examined the incidence of del32 allele in two cohorts (south-western and south-eastern region of country) that remarkably differs in the incidence of HIV. Among the individuals from the south-western region, we detected 7 homozygotes (2.6%), in compare with individuals from the south-eastern area of Poland, where we found 1 homozygote (0.4%). The prevalence of CCR5del32 allele in the group from the southwestern region was estimated at 11.6%, while in the group from the south-eastern region was assessed at 9.7%. Differences in the prevalence of genotypes and alleles between regions were not statistically significant. Our results were discussed in relation to the incidence of HIV infection in Poland. We conclude that occurence of CCR5del32 biomarker does not reflect the incidence of HIV in the examined regions.

Biomarkers and their Role in Premonition, Interpretation and Treatment of Cancer

“…Molecular analysis of CCR5del32 (c.794-925del) variant was carried out with PCR technique using primers Results of PCR amplification were visualized Analysis of the frequency of del32 variant in the CCR5 gene was assessed using the Pearson χ2 test. Occurrence of CCR5del32 biomarker does not reflect the incidence of HIV in the examined regions [9].…”

The Influence of Environmental and Genetic Factors on Various Disorders and Diseases

“…Epidemiological studies suggest that prostate cancer incidence increased in last few years in Asian population [23]. Liposomes are recognized as important vehicles for cytotoxic drugs because they can protect the drugs from degradation in circulation, thereby protecting healthy cells and tissues from exposure to lethal drug doses [24]. In the aetiology of HIV-1 infection, some genetic factors may be important, for example the gene variants, which encode chemokine receptors: CCR5, CCR2 and CXCR4 -SDF-1 ligand receptor.…”

Epigenetic and Therapeutic Analysis of various Neurological Disorders

“…The better therapy for neurohistoplasmosis is unknown [29]. Natural killer (NK) cell function was investigated in Malaysian HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency [30][31][32][33]. The pathogeneses of gastrointestinal diseases are unclear.…”