Distribution of CCR5Δ32, CCR2-64I and SDF1-3′A and plasma levels of SDF-1 in HIV-1 seronegative North Indians

Verma, Romsha; Gupta, R. A.; Singh, Kalpana; Bhasin, Rama; Shukla, Abhay A.; Chauhan, Shashank; Luthra, Kalpana

doi:10.1016/j.jcv.2006.12.006

Cited by 31 publications

(29 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in the present study significant association of either SDF1-3'A polymorphism or CCL3L1 CN towards susceptibility to HIV infection in Indian population was not found. The allelic frequency of SDF1-3'A observed in this study was similar to that reported in North Indian (20.4%) [15] and South Indian (17-35%) [16] populations. The lack of significant association compelled us to think that a single type of genetic variation (like SNP or CNVs) might not show an association towards disease susceptibility or resistance but the combinations of these types of genetic variations could provide a better insight in understanding the mechanism behind the disease development.…”

Section: Discussionsupporting

confidence: 90%

Combinatorial Effects of SDF-1 and CCL3L1 Gene Variants and Susceptibility to HIV-1/AIDS in Indian Population

Almal¹,

Gupta²,

Padh³

2015

JHS

View full text Add to dashboard Cite

HIV-1 infection requires the expression of CD4+ molecules in colligation with C-C chemokine receptor type 5 (CCR5) and C-X-C chemokine receptor type 4 (CXCR4) as the major coreceptors. The role of SNP in 3' untranslated region of SDF-1 (SDF1-3'A) and low copy number (CN) of the CCL3L1 gene is reported to confer increased resistance to HIV-1 infection. The aim of the present study was to analyze the combinatorial effect of both the variations in protection towards HIV-1 infection in Indian population. The combinatorial effect of genetic variation in terms of SNP in SDF-1 gene and CCL3L1 CN was investigated in 105 healthy individuals and 78 HIV-1 patients. Genotyping of SDF-1 was performed by RFLP-PCR and CCL3L1 by real-time PCR using TaqMan chemistry. The genotype frequency distribution of SDF-1 was found to be (SDF-1/SDF-1: 65.4%, SDF-1/SDF1-3'A: 29.5% and SDF1-3'A/SDF1-3'A: 5.1%) in HIV patients as compared to (SDF-1/SDF-1: 64.8%, SDF-1/SDF1-3'A: 30.5% and SDF1-3'A/SDF1-3'A: 4.7%) in healthy individuals, whereas a range of 1 to 6 copies per diploid genome was observed for CCL3L1 gene.

show abstract

Section: Discussionsupporting

confidence: 90%

Combinatorial Effects of SDF-1 and CCL3L1 Gene Variants and Susceptibility to HIV-1/AIDS in Indian Population

Almal¹,

Gupta²,

Padh³

2015

JHS

View full text Add to dashboard Cite

show abstract

“…Amongst the seropositive individuals the frequency was higher at 48 % though the difference was insignificant. Frequency of 48 and 24 % amongst a diverse population in Andhra Pradesh [18] and Northern India [26] respectively were recorded in [9,23]. We recorded only heterozygous mutants for CCR2-64I alleles.…”

Section: Discussionmentioning

confidence: 99%

The Distribution of CCR2-64I, SDF1-3′A and MCP1-2518 G/A Genes Polymorphism in a Specific High Risk Group from the Northeastern States West Bengal, and Gorkha Population in India

Roy

Chakrabarti

2012

Indian J. Virol.

View full text Add to dashboard Cite

We studied the prevalence and effects of host genetic polymorphisms for the three AIDS restriction genes (ARGs) namely CCR2-64I, SDF1-3 0 A and MCP1-2518 G/A for HIV infection and progression to AIDS using PCR-RFLP analysis on a total of 568 HIV seronegative serum samples collected from a specific high risk and young population hailing from the seven Northeastern states of India (n = 346), West Bengal (n = 96) and Gorkha population (n = 101). In addition, 181 HIV seropositive cases of which 92 inpatient cases in a large tertiary care hospital located at Kolkata were included in the study. HIV prevalence in our study group was 0.52 %. Four cases seroconverted, 25 cases progressed to AIDS and 05 died during the follow up period of 41 months. The genotype percentage of CCR2-64I, SDF1-3 0 A and MCP1-2518 G/A in the Northeastern states were 18.5, 40.3 and 54 % respectively in the seronegative population. Allele frequencies for SDF1-3 0 A in Northeastern states were significantly higher as compared to the Gorkha (21 %) and the North Indian population (24 %). Relative Hazard values were more than 0.9 for progression to AIDS and death. KaplanMeier survival analysis using Cox proportional regression model did not reveal any

show abstract

“…However, the disease-retarding role of homozygosity for the CXCL12-3'A allele has not been confirmed in other cohorts (Mummidi et al, 1998;Wang et al, 2003;van Rij et al, 1998;Magierowska et al, 1999;Rousset et al, 1999;Brambilla et al, 2000;Soriano et al, 2002). Verma et al (2007) observed a low frequency of CCR5-Δ32 (1.5%) and of CCR2-64I (9.1%) in healthy Northern Indians, suggesting high vulnerability of North Indians to HIV-1 infection. However, the allelic frequency of the CXCL12 3'A was high (20.4%) in the healthy HIV-1 seronegative Northern Indians included in their study, which was similar to that observed in South Indians (17.0%-35.0%) and South European populations (14.0%-33.0%) (Ramana et al, 2001).…”

Section: Genetic Polymorphisms In CXC Chemokines and Their Receptorsmentioning

confidence: 97%

The Role of Genetic Polymorphisms in the Chemokine and their Receptors and Cytokines in the Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Reiche¹,

Amarante²,

Watanabe³

2011

HIV and AIDS - Updates on Biology, Immunology, Epidemiology and Treatment Strategies

View full text Add to dashboard Cite

Distribution of CCR5Δ32, CCR2-64I and SDF1-3′A and plasma levels of SDF-1 in HIV-1 seronegative North Indians

Cited by 31 publications

References 50 publications

Combinatorial Effects of SDF-1 and CCL3L1 Gene Variants and Susceptibility to HIV-1/AIDS in Indian Population

Combinatorial Effects of SDF-1 and CCL3L1 Gene Variants and Susceptibility to HIV-1/AIDS in Indian Population

The Distribution of CCR2-64I, SDF1-3′A and MCP1-2518 G/A Genes Polymorphism in a Specific High Risk Group from the Northeastern States West Bengal, and Gorkha Population in India

The Role of Genetic Polymorphisms in the Chemokine and their Receptors and Cytokines in the Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Contact Info

Product

Resources

About