Prevalence of A2and A2B subgroups along with anti-A1antibody in patients and donor population and its clinical significance

Mishra, Debasish; Prakash, Satya; Sahoo, Dibyajyoti; Routray, Suman Sudha; Das, Pankaj; Mukherjee, Somnath

doi:10.4103/joah.joah_15_20

Cited by 5 publications

(2 citation statements)

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“…Moreover, they can be troublesome in routine serological blood bank procedures. 10 The present study was conducted to see the prevalence of sub groups A1, A2, A1B and A2B among healthy donors. Very few studies are conducted in Pakistan regarding this topic so the local established data is very limited for comparison.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of A2 and A2B Subgroups among Blood Groups A and AB in healthy donors

Khanum,

Farhan,

Saqlain

et al. 2023

Pak J Med Sci

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Objective: To determine the frequency of A2 and A2B subgroups among blood groups A and AB in healthy donors. Methods: It was a Cross-Sectional study, conducted at the Department of Hematology & Transfusion Medicine, UCHS, The Children’s Hospital Lahore and Sundas foundation Lahore from June 2022 to December 2022 including 13,120 healthy blood donors of both genders, after taking informed consent. Venous blood samples of donors were collected in EDTA vials (3ml) and serum gel vial for routine blood grouping which was done by standard tube method. Further testing of donors positive for an antigen (blood Group-A and AB) was performed using anti-A1 lectin by standard tube method as per manufacturer’s instruction. The data was analyzed using SPSS version 23. Results: Among 13120 blood donors, 12857 (97.9%) were male and 263 (2.0%) were female with mean age of 36.7 years ± 15.04 years. Majority of them (91.7%) were of Punjabi ethnicity. Donors having blood group phenotype A and AB were 3890 (29.6%). Among blood Group-A donors, A1 was found in 97.8% and A2 in 2.2% donors. While among Blood Group-AB, 96.7% donors belonged to A1B blood group and 3.2% belonged to A2B blood group. Conclusions: Blood group A2 and A2B do exist in blood donors of Punjabi ethnicity. The knowledge of presence of these blood groups’ phenotypes in our population can provide a better base for transfusion staff to do troubleshooting in compatibility testing and to avoid any rare but hazardous transfusion outcome. doi: https://doi.org/10.12669/pjms.40.1.7916 How to cite this: Khanum A, Farhan S, Saqlain N, Arshad S. Prevalence of A2 and A2B Subgroups among Blood Groups A and AB in healthy donors. Pak J Med Sci. 2024;40(1):---------. doi: https://doi.org/10.12669/pjms.40.1.7916 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Prevalence of A2 and A2B Subgroups among Blood Groups A and AB in healthy donors

Khanum,

Farhan,

Saqlain

et al. 2023

Pak J Med Sci

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“…In the forward grouping, A3, Aend, Ax and Am may show weak agglutination with anti-A and/or Anti-AB, while Ay and Ael cells are not agglutinated 4,7 . A3 subgroups show a mixed-field appearance in the forward grouping, demonstrating agglutinates in the background of abundant free cells 6 . Weaker A subgroups are differentiated from the A1 group by test using anti-A1 lectin, which reacts only with A1 cells leaving A2 and other weaker subgroups as a non-reactive.…”

Section: Introductionmentioning

confidence: 98%

Patient with a rare weaker subgroup-A exhibiting ABO discrepancy: a case report

Yousuf,

Yusof,

Suhemi

et al. 2024

Bangladesh J Med Sci

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Weaker subgroups have the potential to cause problems in the immunohaematological testing in the blood banks. We report here a case of rare weaker subgroup A, detected during the usual ABO grouping. A 49-year-old lady exhibited a discrepancy in the forward and reverse groupings. In forward-grouping, there was a mixedfield reaction with anti-A and anti-A,B while there was no reaction with anti-B. The reverse grouping showed no reaction with the A1 and A2 cells, but the reaction with B-cell was 4+. Further tests were performed and revealed a weaker subgroup of A. It is crucial to properly investigate and resolve any discrepancy in ABO grouping before commencing transfusion to avoid any wrong blood transfusion. This case report may assist others in resolving the ABO blood group discrepancies. Bangladesh Journal of Medical Science Vol. 23 No. 02 April’24 Page : 546-550

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Risk of obstructive sleep apnea syndrome among adult patients with sickle cell disease in Saudi Arabia

Jabr¹,

Althabit²,

Alonayzan³

et al. 2021

IJMDC

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Prevalence of A₂and A₂B subgroups along with anti-A₁antibody in patients and donor population and its clinical significance

Cited by 5 publications

References 1 publication

Prevalence of A2 and A2B Subgroups among Blood Groups A and AB in healthy donors

Prevalence of A2 and A2B Subgroups among Blood Groups A and AB in healthy donors

Patient with a rare weaker subgroup-A exhibiting ABO discrepancy: a case report

Risk of obstructive sleep apnea syndrome among adult patients with sickle cell disease in Saudi Arabia

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