Prevalence, clinical features and risk assessment of pre-diabetes in Spain: the prospective Mollerussa cohort study

Abstract

PurposeThe Mollerussa prospective cohort was created to study pre-diabetes in a population-based sample from the primary care setting in the semirural area of Pla d’Urgell in Catalonia (Spain). The aims of the study were to assess the prevalence of pre-diabetes in our population, the likelihood to develop overt diabetes over time and to identify risk factors associated with the progression of the condition.ParticipantsThe cohort includes 594 subjects randomly selected between March 2011 and July 2014 from our primary care population, who were older than 25 years, consented to participate and did not have a recorded diagnosis of diabetes.Findings to dateAt baseline, we performed a clinical interview to collect demographic, clinical and lifestyle (including a nutritional survey) characteristics; carotid ultrasound imaging to assess subclinical cardiovascular disease was also performed, and a blood sample was collected, with an overall <5% rate of missing data. An additional blood draw was performed 12 months after initial recruitment to reassess laboratory results in patients initially identified as having pre-diabetes, with an 89.6% retention rate. Several studies investigating various hypotheses are currently ongoing.Future plansAll subjects recruited during the cohort creation will be followed long-term through annual extraction of data from health records stored in the electronic Clinical station in Primary Care database. The Mollerussa cohort will thus be a sound population-based sample for multiple future research projects to generate insights into the epidemiology and natural history of pre-diabetes in Spain.

Spanish People with Type 2 Diabetes Show an Improved Adherence to the Mediterranean Diet

“…First, the cross-sectional study design did not allow us to establish a causal relationship between variables and study outcomes. Furthermore, this was a sub-study of previous studies, mainly designed to assess the quality of life and treatment satisfaction of participants with T2D [20], and the prevalence of prediabetes [21]. Although these findings may reflect the educational dietary intervention received from healthcare professionals, we cannot establish a direct link, as we did not assess the specific knowledge about the dietary recommendations in participants with diabetes.…”

“…A total sample of 238 participants with T2D and 238 sex-and age-matched participants without diabetes were recruited. This was a sub-study using the cohorts of two previously published studies [20,21]: the first one included a cohort of subjects with T2D designed to assess their quality of life and treatment satisfaction; the second study was a population-based cohort study designed to assess the prevalence of prediabetes, and risk factors associated with this condition. Participants with T2D were recruited at the University Hospital Arnau de Vilanova in Lleida (Spain), the reference specialized hospital for the province of Lleida.…”

“…The exclusion criteria were the same as in the T2D group, together with the diagnosis of diabetes. More details on the characteristics of the two study groups are described in the previous publications [20,21]. The recruitment of both studies occurred between March 2010 and July 2014.…”

“…Medical records were thoroughly reviewed to collect clinical and sociodemographic data. Blood samples and anthropometric variables were collected by standardized methods; these were detailed in previous publications [20,21]. Hypertension and dyslipidemia were defined as receiving medication for these given conditions (i.e.…”

Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia

“…This was a prospective population-based cohort study from the semi-rural area of ​​Mollerussa in Catalonia (northeast Spain) selected between March 2011 and July 2014. The description of the cohort and the procedures performed were initially published as a cohort profile 17. Briefly, the database of the Catalan Health Institute (ICS) through its Primary Care Electronic Clinical Station (Estació Clínica Electronica d’Atenció Primaria – eCAP) was used to select the population sample.…”