Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia

Richter, Bernd; Hemmingsen, Bianca; Metzendorf, Maria‐Inti; Takwoingi, Yemisi

doi:10.1002/14651858.cd012661.pub2

Cited by 146 publications

(189 citation statements)

References 603 publications

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“…We further divided CAD cases into CAD without T2D group (CAD-T2D, n = 108) and CAD with T2D group (CAD + T2D, n = 57). T2D was diagnosed according to standard world health organization criteria with fasting glucose ≥ 7.0 mmol/l or non-fasting glucose ≥ 11.1 mmol/l [19]. Subjects with an active infection, malignancy, severe liver or heart cerebrovascular diseases, severe proteinuria (> 3.5 g/day), intestinal dysfunction, gastrointestinal surgery history, choline or betaine supplementation in recent 6 months were excluded.…”

Section: Materials and Methods Study Population And Designmentioning

confidence: 99%

Low serum betaine levels as a potential biomarker for type 2 diabetes mellitus in patients with coronary artery disease

Guo

Qiu

Zhu

et al. 2020

Preprint

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Background Dietary betaine intake was reported to associate with improved metabolic profile in type 2 diabetes (T2D). However, the role of circulating betaine in coronary artery disease (CAD) patients with T2D is still unknown. This study aimed to investigate the potential role of serum betaine as a potential biomarker for T2D risk in CAD patients. Methods Total 307 subjects were enrolled with 165 CAD patients (57 with T2D and 108 without) and 142 age and sex matched controls (CON). Fasting serum betaine were detected using liquid chromatography tandem mass spectrometry. Results Serum betaine were lower in simple CAD patients compared with healthy controls, and were further decreased in CAD patients with T2D. Betaine was inversely associated with fasting glucose. Subjects in the highest betaine tertile group had lower triglycerides, total cholesterol and low-density lipoprotein as well was lower percentage of CAD and T2D. Increased betaine in CAD was independently associated with low risk of T2D. Furthermore, betaine was a potential diagnostic marker in distinguishing simple CAD from CAD with T2D. Conclusion Low levels of betaine are associated with increased risk of CAD and T2D in CAD, and could be a biomarker for predicting T2D in CAD.

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Section: Materials and Methods Study Population And Designmentioning

confidence: 99%

Low serum betaine levels as a potential biomarker for type 2 diabetes mellitus in patients with coronary artery disease

Guo

Qiu

Zhu

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Diabetes mellitus was de ned as either FPG ≥7 mmol/L or 2 h oral glucose tolerance test (OGTT) blood glucose ≥11.1 mmol/L, while impaired fasting glucose was de ned as 6.1 mmol/L≤FPG<7 mmol/L [15].…”

Section: Secondary Outcomesmentioning

confidence: 99%

Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Jiang

Huang

et al. 2020

Preprint

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Background Obesity is a globally increasing health epidemic requiring early lifestyle intervention. Our main objective was to examine the effectiveness of companion-intensive multi-aspect weight management (CIMWM) for Chinese adults with obesity. Methods In this 6-month, prospective, open-label, multicenter, randomized controlled clinical trial, we included 272 obese adults aged 18–50 years with a body mass index (BMI) ≥ 28.0 kg/m2 and capable of using smartphones. CIMWM (n = 136) offered both daily online instructions and monthly face-to-face guidance by physicians, dietitians, and health managers along with the provision of meal replacements in the first 3 months. Traditional multi-aspect weight management (TMWM, n = 136) provided monthly face-to-face guidance by the above-mentioned professionals and required daily self-monitoring. Measurements of body composition and metabolic parameters were assessed face-to-face at baseline, 1, 2, 3, and 6 months by physicians. Primary outcomes were the changes in BMI and body composition. Results All participants showed significantly reduced BMI, body fat mass (BFM), visceral fat area (VFA), and HOMA-IR (P < 0.05). CIMWM was shown to be superior to TMWM in the improvement of BMI, alanine aminotransferase (ALT), and the body composition parameters BFM and VFA (P < 0.05). The relationship of baseline non-alcoholic fatty liver disease score (NFS) was positively related to the skeletal muscle mass-to-visceral fat area ratio (S/V). Additionally, the weight management program was beneficial in lowering the NFS among subjects with levels in the highest tertile (P < 0.05). Metabolic memory in terms of the continuous reduction of BMI, VFA, and ALT was retained up to 6 months in spite of participants transferring to self-monitored assessment in the final 3 months. Conclusions The CIMWM strategy in obese Chinese adults proved to be more effective than TMWM, and motivates greater adherence to intervention and lifestyle reprogramming. Trial registration: ChiCTR1800017463, Registered 31 July 2018, retrospectively registry. http://www.chictr.org.cn/showproj.aspx?proj=29649

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“…Az adatok azonban nem egységesek, aminek magyarázata az egyes formák meghatározási különbségeiben kereshető. 18 Kétségtelen, hogy minél jelentősebb a vércukorértékek normálistól való eltérése (IGT vs. iIGT vs. IFG), annál nagyobb az esélye vég-glikációs termékek fokozott képződésének, az általuk triggerelt gyulladásos folyamatok felerősödésének, az oxidatív stressz szöveti érvényesülésének, valamint az érfali struktúra következményes változásának. 3 támasztja alá az Atherosclerosis Risk in Communities (ARIC) vizsgálat megfigyelése is, miszerint a klinikai következmények előrejelzése tekintetében a prediabetes HbA 1c alapján való definiálása volt a leginformatívabb.…”

Section: A Prediabetes Egészségkárosító Hatásaunclassified

A metformin helye a prediabetes kezelésében – ahogyan ma látjuk

Winkler¹

2019

Diabetologia Hungarica

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ÖsszefoglalásA prediabetes a szénhidrátanyagcsere-zavarok azon formáinak összefoglaló neve, amelyekben az éhomi és/vagy a glukózterhelést követő vércukorszint magasabb a normálisnál, de nem éri el a manifeszt diabetesre kórjelző mértéket. A 2-es típusú diabetes prevalenciájával egyezően gyakorisága világszerte exponenciálisan emelkedik. Nagy, részben vascularis, részben metabolikus kockázatú állapot, megelőzése, illetve a már kialakult kórforma visszafordítása egyben a 2-es típusú diabetes prevencióját is jelenti. E céllal számos eljárás hatékonyságát vizsgálták, s az intenzív életmódkezelés, illetve a gyógyszeres lehetőségek közül a metformin bizonyult a leghatékonyabbnak. A prediabetes heterogén állapot, egyes formáinak patogenezise részben eltérő, a metformin azonban -közvetlen támadásponttal fokozva a hepatikus és az egész test inzulinérzékenységét, közvetve a GLP-1 release erősítésével javítva az inzulinelválasztást -mindegyikben azonosan eredményesnek bizonyult. A két eljárás, az életmódkezeléssel kezdve, alkalmazható szekvencviálisan is, nagy diabeteskockázat esetén azonban a kettő egyidejű megkezdése tanácsolható. ■ Kulcsszavak: prediabetes, IFG, IGT, életmódkezelés, metformin, kezelési stratégiaThe place of metformin in the treatment of prediabetes -how it looks like Summary: The term prediabetes is the common name of metabolic disturbances, where the fasting and/or the postload blood glucose level is higher than normal, but does not reach values characteristic for manifest diabetes mellitus. Parallel with the prevalence of type 2 diabetes also its frequency increases exponentially. Prediabetes is a state with significant vascular and metabolic risk, its prevention or the reversal of the already developed damage means also the prevention of type 2 diabetes. To stop or reverse prediabetes different intervention possibilities have been studied. Among them intensive life style change and as a pharmaceutical therapy, metformin proved to be the most effective. The prediabetes is a heterogeneous state, the pathogenesis of the different forms is partly different. However, metformin was equally effective in all of them, increasing both, directly the hepatic and whole body insulin sensitivity and indirectly, via the GLP-1 release, the insulin secretion. Life style change and metformin can be applied sequentially -at first the former one and at second, for its support, metformin -, however when the diabetes risk is high, the concurrent introduction of both is the optimal choice of therapy. ■ Keywords: prediabetes, IFG, IGT, life style treatment, metformin, therapeutic strategy DIABETOLOGIA HUNGARICA 27 (№3) 171-179. 2019. szeptember Rövidítések AMPK: adenozin-monofoszfát aktiválta kináz; b.i.d.: naponta kétszer (bis daily); DPP: Diabetes Prevenciós Program (Diabetes Prevention Program); HOMA-Β: homeosztatikus modell az inzulinelválasztás jellemzésére (homeostasis model assessment for beta-cell function); iIGT: izolált IGT; MRCC: mitochondrialis légzési lánc komplex (mitochondrial respiratory chain complex); NGT: n...

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Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia

Abstract: Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia (Review)

Cited by 146 publications

References 603 publications

Low serum betaine levels as a potential biomarker for type 2 diabetes mellitus in patients with coronary artery disease

Low serum betaine levels as a potential biomarker for type 2 diabetes mellitus in patients with coronary artery disease

Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

A metformin helye a prediabetes kezelésében – ahogyan ma látjuk

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