Prevalence and trends of human papillomavirus in oropharyngeal cancer in a predominantly north Indian population

Bahl, Ankur; Kumar, Pankaj; Dar, Lalit; Mohanti, B.K.; Sharma, Atul; Thakar, Alok; Karthikeyan, Venkat; Sikka, Kapil; Venkatakarthikeyan, C; Poo, Kamala; Lodha, Jaini

doi:10.1002/hed.23317

Cited by 57 publications

(68 citation statements)

References 42 publications

(98 reference statements)

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“…Subsequently, we determined the efficiency of MP-RCA to amplify circular HPV DNA in 9 clinical samples, including 3 anal swabs, 3 cervical swabs, and 3 oral rinse samples. Regardless of the source of samples, MP-RCA preferentially amplified HPV DNA 100-10 7 fold. Of three oral rinse samples, HPV 16 was amplified 10 5 and 10 6 fold in CS7 and CS8 respectively, and HPV 59 was amplified 7000 fold in CS9.…”

Section: Resultsmentioning

confidence: 99%

Characterization of three novel human papillomavirus types isolated from oral rinse samples of healthy individuals

Martin

Dang

Bzhalava

et al. 2014

Journal of Clinical Virology

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Background Despite the strong evidence of HPV infection as the etiological agent in a subset of oral cancer, oral α-HPV detection is rare in healthy individuals, and little is known of the existing of novel HPV types in oral cavity. Objective We determined whether novel HPV types can be isolated from oral rinse samples collected from healthy individuals. Study design We performed rolling circle amplification (RCA) coupled with degenerated PCR assay on 48 oral rinse samples to amplify novel HPV types. Full length HPV DNA was cloned using long range PCR. Quantitative type specific Taqman assays were used to determine the prevalence of novel HPV types in 158 archived oral tissue samples. Results We were able to isolate four novel human papillomavirus types. Full length HPV DNA was cloned for three of the four novel HPV types. All four HPV types belong to the genus Gammapapillomavirus (γ-PV), where HPV 171 is most closely related to HPV 169, showing 88% similarity; HPV 172 is most closely related to HPV 156, showing 70% similarity; HPV 173 is most closely related to HPV 4, showing 73% similarity; oral sample lavage (OSL) 37 is most closely related to HPV 144, showing 69% similarity. Finally, we showed that HPV 173 was rarely present in oral tissues (2/158), HPV 172 was only detected in normal oral tissues (25/76), and HPV 171 was more prevalent in malignant oral tissues (17/82 vs 10/76, p=0.21). Conclusions Novel γ-HPV types are present in oral cavity of healthy individuals.

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Section: Resultsmentioning

confidence: 99%

Characterization of three novel human papillomavirus types isolated from oral rinse samples of healthy individuals

Martin

Dang

Bzhalava

et al. 2014

Journal of Clinical Virology

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“…Sexual liberation is more commonly seen in Western countries and less so on the Indian subcontinent due to sexual convention. HPV prevalence in oropharyngeal cancer was 22.8% in a north Indian population 52. Higher chances of acquiring HPV-positive HNSCC were seen in those who were light smokers (63.4%), had a higher income (48%) and had higher levels of education (45.3%) 20…”

Section: Current Scenariomentioning

confidence: 99%

Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature

Shah

Malik

Garg

et al. 2017

Postgraduate Medical Journal

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Head neck squamous cell carcinomas (HNSCCs) are a significant cause of morbidity and mortality all around the world. Just like tobacco and alcohol, Human papilloma virus (HPV) infection is now recognized to play a role in the pathogenesis of a subset of HNSCCs. Unprotected sexual behaviours with the HPV carrier plays an important role in transmission of this virus. The global incidence of head and neck cancers is declining, but the incidence of HPV related head and neck cancers is rapidly increasing over the last few decades. However, most institutions do not mandate documentation of sexual history or counselling of patients regarding sexual practices like they do for tobacco and alcohol addictions in HNSCC patients. The aim of this review of literature is to analyse if there is a strong evidence to correlate oral sex with HPV related HNSCC and counsel the patient's regarding sexual behaviours.

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“…In our research we identify 15 articles focused on HPV associated oropharyngeal cancer and sexual behavior as a risk factor 1,3,9,[11][12][13][14][15][16][17][18][19][20][21][22] . One article studied the knowledge of HPV and its association with oropharyngeal cancer in a high-risk population 16 .…”

Section: Resultsmentioning

confidence: 99%

“…The other affirms that the HPV has influence in the oropharyngeal cancer depending on its viral load and stage and that's not determined by demographic or behavioral factors 14 . The other ten articles affirm the HPV can be used as sexual behavior marker 9,[11][12][13][17][18][19][20][21][22] , but each article used a different aspect of sexual behavior to establish that.…”

Section: Resultsmentioning

confidence: 99%

“…The many aspects of sexual behavior used to determine if it can be used as a marker was number of sexual partners 3,16,17,19,21,22 , practicing oral-genital sex 18,20 , number of oral-genital sex partners 3,11,12,22 , practicing oral-anal sex 20 , age of first sexual interaction 16,17 , age of first oral-genital sexual interaction 17 , perception of risk of sexually transmitted disease (16) and marital status 9 .…”

Section: Resultsmentioning

confidence: 99%

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HPV positive oropharyngeal cancer: risky sexual behavior

Oliveira

Santos

Hojaij

2018

Rev. Med. (São Paulo)

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Rev Med (São Paulo ABSTRACT: Oropharyngeal squamous cell carcinomas have traditionally been associated with tobacco and alcohol use. Although smoking rates had been decreasing, there is an increase in the incidence of Oropharyngeal squamous cell carcinomas in the last years. This increase of Oropharyngeal squamous cell carcinomas is noticed in one specific type, Oropharyngeal squamous cell carcinomas associated with human papillomavirus (HPV) infection, mainly the HPV16 type, a high-risk HPV. Transmission of HPV is known as occur through sexual contact but many researches differ on which kind of sexual contact is the responsible for the HPV infection. Objective: The objective of this review is to verify in the literature if there is a pattern of sexual behavior that is more related with oropharyngeal squamous cell carcinoma HPV positive. The habits most associated with Oropharyngeal squamous cell carcinomas are oral sex and multiples sexual partners. The occurrence of this habits in the population varies from local culture, social status and ethnic group. In this context, health care professionals have a major responsibility in orientating about aspects of the disease, risk factors, vaccination and prognosis. Further researches are necessary to clarify the role of vaccination for HPV in future changes in the Oropharyngeal squamous cell carcinomas prevalence.Keywords: Oropharyngeal cancer; Papillomaviridae; Sexual behavior; Carcionma, squamous cell. RESUMO:O carcinoma de células escamosas de orofaringe é tradicionamente associado com uso de tabaco e álcool. Apesar da prevalência de tabagistas ter diminuído, a prevalência de carcinoma de células escamosas de orofaringe vem aumentando. Esse aumento do carcinoma de células escamosas de orofaringe pode ser notado em um tipo específico, o associado com infecção pelo papilomavirus humano (HPV), principalmente o HPV 16, um subtipo de HPV de alto risco. A transmissão do HPV é conhecidamente por contato sexual, mas muitas pesquisas diferem quanto ao tipo de contato responsável pela infecção pelo HPV. Objetivo: O objetivo dessa revisão é verificar se existe na literatura um padrão de comportamento sexual que está mais relacionado com o câncer de orofaringe HPV positivo. Os hábitos mais associados com carcinoma de células escamosas de orofaringe são realização de sexo oral e múltiplos parceiros sexuais. A ocorrência desses hábitos na população variam conforme a cultura local, nível social e grupos étnicos. Nesse contexto, profissionais de saúde têm grande responsabilidade na orientação sobre aspectos da doença, fatores de risco, vacinação e prognósticos. Outras pesquisas ainda são necessárias para determinar qual é o papel da vacinação contra HPV em futuras mudanças na prevalência do carcinoma de células escamosas de orofaringe.Descritores: Neoplasias orofaríngeas; Papillomaviridae; Comportamento sexual; Carcinoma de células escamosas. 99Oliveira DC, et al. HPV positive oropharyngeal cancer: risky sexual behavior.

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Prevalence and trends of human papillomavirus in oropharyngeal cancer in a predominantly north Indian population

Abstract: Results of this study confirms that patients who are HPV positive are younger, and with high-risk sexual behavior. We did not find any impact of smoking and alcohol consumption on HPV status.

Cited by 57 publications

References 42 publications

Characterization of three novel human papillomavirus types isolated from oral rinse samples of healthy individuals

Characterization of three novel human papillomavirus types isolated from oral rinse samples of healthy individuals

Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature

HPV positive oropharyngeal cancer: risky sexual behavior

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