Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature

Shah, Ankit B.; Malik, Akshat; Garg, Akhil Ranjan; Mair, Manish; Nair, Sudhir; Chaturvedi, Pankaj

doi:10.1136/postgradmedj-2016-134603

Cited by 33 publications

(19 citation statements)

References 49 publications

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“…The most important risk factors identi ed so far for HNSCC are excessive tobacco (3,4) and alcohol consumption (5-7) together with high-risk types of human papillomavirus (HPV) (8)(9)(10). Although the global incidence of HNSCC is declining, the incidence of HPV related HNSCC, especially oropharyngeal and oral squamous cell carcinoma (OPSCC, OSCC, respectively) is rapidly increasing over the last few decades (11). Recent ndings emphasize the importance of epigenetic changes, such as DNA methylation and alterations including micro RNAs (miRNA), in HNSCC progression and implicate the very role of tobacco and alcohol (12) as well as HPV (13) in those changes.…”

Section: Introductionmentioning

confidence: 99%

DNA Methylome Distinguishes Oropharyngeal and Oral Cancer from Oral Lesions and Healthy Oral Mucosa

Nina

Sabol

Božinović

et al. 2020

Preprint

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Background: There is a strong need to find new, good biomarkers of head and neck squamous cell carcinoma (HNSCC), because of the prognoses and high mortality of patients. The aim of this study was to identify the potential biomarkers in HNSCC that have differences in their DNA methylome and potentially premalignant oral lesions, in comparison to healthy oral mucosa.Methods: In this study 32 oral samples were tested: 9 healthy oral mucosae, 13 HNSCC and 10 potentially premalignant oral lesions for DNA methylation by Infinium MethylationEPIC BeadChip.Results: Our findings showed a panel of genes significantly hypermethylated in their promoters or specific sites in HNSCC samples in comparison to healthy oral samples, which are mainly oncogenes, receptor and transcription factor genes, or genes included in cell cycle, transformation, apoptosis and autophagy. A group of hypomethylated genes in HNSCC, in comparison to healthy oral mucosa, is mainly involved in the host immune response and transcriptional regulation. The results also showed significant differences in gene methylation between HNSCC and potentially premalignant oral lesions, as well as differently methylated genes that discriminate between oral lesions and healthy mucosa.Conclusions: The given methylation panels point to the possibly early diagnostics of HNSCC as well as potentially premalignant oral lesions and its possible implication in clinical practice.

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Section: Introductionmentioning

confidence: 99%

DNA Methylome Distinguishes Oropharyngeal and Oral Cancer from Oral Lesions and Healthy Oral Mucosa

Nina

Sabol

Božinović

et al. 2020

Preprint

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“…Until now, there is no study exploring the above associations in Chinese population, in which the composition of HNSCCs is quite different from that in non-Hispanic Whites population. Speci cally, oropharyngeal cancers account for the most of HPV-positive HNSCCs in the United States, and the HPV-positive oropharyngeal cancer cases in previous non-Hispanic Whites study were about 91.4% of all the oropharyngeal cancer cases, while in Chinese population the most of oropharyngeal cancer cases are HPV-negative, meaning they are primarily caused by cigarette smoking [29][30][31][32][33]. In addition, the etiology of smoking-related HNSCCs is different from that of HPVpositive HNSCCs [34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Nucleotide Excision Repair Proteins and Risk of Head and Neck Squamous Cell Carcinomas in a Chinese Population

Ren

Niu

Zhao

et al. 2020

Preprint

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Background Nucleotide excision repair (NER) is pivotal in the development of smoking-related malignancies. We hypothesize that expression levels of NER proteins are associated with risk of the head and neck squamous cell carcinomas (HNSCCs) in a Chinese population. Methods To test this hypothesis, we conducted a case-control study of 337 HNSCC patients and 285 cancer-free controls by measuring the expression levels of nine core NER proteins in cultured peripheral lymphocytes. Results Compared with the controls, cases had statistically significantly lower expression levels of XPA (P=0.001). After dividing the subjects by controls’ medians of expression levels, we found an association between an increased risk of HNSCCs and low XPA expression levels [adjusted ORs and 95% CIs:1.42 and 1.03-1.96; Ptrend=0.031]. We identified a multiplicative interaction between smoking as well as drinking status and XPA expression levels (P = 0.005 and 0.044, respectively). Finally, the sensitivity of the expanded model with protein expression levels, in addition to demographic variables, on HNSCCs risk was significantly improved, especially among ever smokers and ever drinkers. Conclusions Reduced XPA expression levels were associated with an increased risk of HNSCCs in a Chinese population.

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“…Human papillomaviruses (HPVs) are non-enveloped DNA viruses with more than 220 different types identified to date [1][2][3]. Approximately, 40 of these HPV types are transmitted sexually through anogenital-to-anogenital sex or anogenital-to-oral sex [4,5], and 19 HPV types can cause cancers. Anogenital HPV infections are associated with cervical cancer, vaginal cancer, penile cancer, anal cancer, and genital warts [6][7][8][9][10] whereas oral HPV infections are associated with head and neck cancers (HNCs; oral, oropharyngeal, laryngeal cancers, etc.)…”

Section: Introductionmentioning

confidence: 99%

Oral immunization with bacteriophage MS2-L2 VLPs protects against oral and genital infection with multiple HPV types associated with head & neck cancers and cervical cancer

et al. 2019

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Human papillomaviruses (HPVs) are the most common sexually transmitted infections. HPVs are transmitted through anogenital sex or oral sex. Anogenital transmission/infection is associated with anogenital cancers and genital warts while oral transmission/infection is associated with head and neck cancers (HNCs) including recurrent respiratory papillomatosis. Current HPV vaccines protect against HPV types associated with ~90% of cervical cancers and are expected to protect against a percentage of HNCs. However, only a few studies have assessed the efficacy of current vaccines against oral HPV infections. We had previously developed a mixed MS2-L2 candidate HPV vaccine based on bacteriophage MS2 virus-like particles (VLPs). The mixed MS2-L2 VLPs consisted of a mixture of two MS2-L2 VLPs displaying: i) a concatemer of L2 peptide (epitope 20-31) from HPV31 & L2 peptide (epitope 17-31) from HPV16 and ii) a consensus L2 peptide representing epitope 69-86. The mixed MS2-L2 VLPs neutralized/protected mice against six HPV types associated with ~87% of cervical cancer. Here, we show that the mixed MS2-L2 VLPs can protect mice against additional HPV types; at the genital region, the VLPs protect against HPV53, 56, 11 and at the oral region, the VLPs protect against HPV16, 35, 39, 52, and 58. Thus, mixed MS2-L2 VLPs protect against eleven oncogenic HPV types associated with ~95% of cervical *

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Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature

Cited by 33 publications

References 49 publications

DNA Methylome Distinguishes Oropharyngeal and Oral Cancer from Oral Lesions and Healthy Oral Mucosa

DNA Methylome Distinguishes Oropharyngeal and Oral Cancer from Oral Lesions and Healthy Oral Mucosa

Nucleotide Excision Repair Proteins and Risk of Head and Neck Squamous Cell Carcinomas in a Chinese Population

Oral immunization with bacteriophage MS2-L2 VLPs protects against oral and genital infection with multiple HPV types associated with head & neck cancers and cervical cancer

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