Prevalence and Risk Factors of Epilepsy Among School Children in Eastern Turkey

Huseyinoglu, Nergiz; Özben, Serkan; Arhan, Ebru; Palanci, Yılmaz; Güneş, Nurettin

doi:10.1016/j.pediatrneurol.2012.04.007

Cited by 28 publications

(27 citation statements)

References 34 publications

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“…Antenatal difficulties are associated with epilepsy 49 . Birth asphyxia is a risk factor for epilepsy and neonatal mortality, but is preventable 28 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies

Ngugi

Bottomley

Kleinschmidt

et al. 2013

The Lancet Neurology

269

328

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SummaryBackgroundThe prevalence of epilepsy in sub-Saharan Africa seems to be higher than in other parts of the world, but estimates vary substantially for unknown reasons. We assessed the prevalence and risk factors of active convulsive epilepsy across five centres in this region.MethodsWe did large population-based cross-sectional and case-control studies in five Health and Demographic Surveillance System centres: Kilifi, Kenya (Dec 3, 2007–July 31, 2008); Agincourt, South Africa (Aug 4, 2008–Feb 27, 2009); Iganga-Mayuge, Uganda (Feb 2, 2009–Oct 30, 2009); Ifakara, Tanzania (May 4, 2009–Dec 31, 2009); and Kintampo, Ghana (Aug 2, 2010–April 29, 2011). We used a three-stage screening process to identify people with active convulsive epilepsy. Prevalence was estimated as the ratio of confirmed cases to the population screened and was adjusted for sensitivity and attrition between stages. For each case, an age-matched control individual was randomly selected from the relevant centre's census database. Fieldworkers masked to the status of the person they were interviewing administered questionnaires to individuals with active convulsive epilepsy and control individuals to assess sociodemographic variables and historical risk factors (perinatal events, head injuries, and diet). Blood samples were taken from a randomly selected subgroup of 300 participants with epilepsy and 300 control individuals from each centre and were screened for antibodies to Toxocara canis, Toxoplasma gondii, Onchocerca volvulus, Plasmodium falciparum, Taenia solium, and HIV. We estimated odds ratios (ORs) with logistic regression, adjusted for age, sex, education, employment, and marital status.Results586 607 residents in the study areas were screened in stage one, of whom 1711 were diagnosed as having active convulsive epilepsy. Prevalence adjusted for attrition and sensitivity varied between sites: 7·8 per 1000 people (95% CI 7·5–8·2) in Kilifi, 7·0 (6·2–7·4) in Agincourt, 10·3 (9·5–11·1) in Iganga-Mayuge, 14·8 (13·8–15·4) in Ifakara, and 10·1 (9·5–10·7) in Kintampo. The 1711 individuals with the disorder and 2032 control individuals were given questionnaires. In children (aged <18 years), the greatest relative increases in prevalence were associated with difficulties feeding, crying, or breathing after birth (OR 10·23, 95% CI 5·85–17·88; p<0·0001); abnormal antenatal periods (2·15, 1·53–3·02; p<0·0001); and head injury (1·97, 1·28–3·03; p=0·002). In adults (aged ≥18 years), the disorder was significantly associated with admission to hospital with malaria or fever (2·28, 1·06–4·92; p=0·036), exposure to T canis (1·74, 1·27–2·40; p=0·0006), exposure to T gondii (1·39, 1·05–1·84; p=0·021), and exposure to O volvulus (2·23, 1·56–3·19; p<0·0001). Hypertension (2·13, 1·08–4·20; p=0·029) and exposure to T solium (7·03, 2·06–24·00; p=0·002) were risk factors for adult-onset disease.InterpretationThe prevalence of active convulsive epilepsy varies in sub-Saharan Africa and that the variation is probably a result of differences in risk factors. Prog...

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“…Antenatal difficulties are associated with epilepsy 49 . Birth asphyxia is a risk factor for epilepsy and neonatal mortality, but is preventable 28 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies

Ngugi

Bottomley

Kleinschmidt

et al. 2013

The Lancet Neurology

269

328

View full text Add to dashboard Cite

show abstract

“…In the Arab world where first-degree consanguineous marriages represent more than 60% of all unions (Etude, 2007), the association to epilepsy has been suggested by some studies (Asadi-Pooya, 2005;Choueiri et al, 2001;Khedr et al, 2013;Benamer and Grosset, 2009;Bourrous et al, 2010) and refuted by others (Daoud et al, 2003;Cansu et al, 2007;Huseyinoglu et al, 2012;Yemadje et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Consanguinity and epilepsy in Oran, Algeria: A case–control study

et al. 2015

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“…Although the majority of the studies made in different regions of Turkey report higher prevalence in males, some studies found no difference between genders 18 . In other studies, the prevalence of the disease was higher among females 19,20 . Prevalence of active epilepsy was 4/1,000 in females, 7/1,000 in males and 6/1,000 in both groups together in another research 21 .…”

Section: Discussionmentioning

confidence: 54%

Mental health problems in children with uncomplicated epilepsy; relation with parental anxiety

Gökgöz-Durmaz

Ci̇han

Meltem³

et al. 2016

Turk J Pediatr

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In those with epilepsy, 39.8% (n: 33) were girls, 60.2% (n: 50) were boys and their mean age was 9.34 ± 3.99 years. Control group was more successful in school (p<0.001). Emotional problems score in children with epilepsy was higher than control group (p<0.001). Case group's behavior problems and attention deficit hyperactivity scores were higher (p<0.001, p=0.009 respectively). Prosocial behavior scores of the control group were significantly higher (p=0.004). State (p=0.001) and trait (p=0.001) anxiety levels of parents of children with epilepsy were higher.Children with epilepsy have more neuro-behavioral problems; and their parents have greater anxiety levels. Physicians should be in contact with children with epilepsy for the psychological health of the family besides seizure control.

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Prevalence and Risk Factors of Epilepsy Among School Children in Eastern Turkey

Cited by 28 publications

References 34 publications

Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies

Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies

Consanguinity and epilepsy in Oran, Algeria: A case–control study

Mental health problems in children with uncomplicated epilepsy; relation with parental anxiety

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