Prevalence and risk factors for work related asthma in young adults

Caldeira, Roseane Durães; Bettiol, Heloísa; Barbieri, Marco Antônio; Terra-Filho, João; Garcia, Clécia Aparecida; Vianna, Elcio Oliveira

doi:10.1136/oem.2005.025916

Cited by 45 publications

(47 citation statements)

References 46 publications

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“…Lower level of education (1-8 years of schooling) with an OR of 7.1 was reported to be associated with occupational asthma in the Brazilian study (19) and illiteracy (OR=2.1) in the Pakistani study.10 In the present study even though low level of education emerged significant in the bivariate analysis, it did not remain same when adjusted for confounding factors.…”

Section: Discussioncontrasting

confidence: 48%

“…Atopy was reported to be significantly associated with occupational asthma in the British Columbian study (11), the Brazilian study (19) and the studies on animal shelter workers (20) and dental health care workers.17 In the British Columbian study family history was observed to be a risk factor for BA both before and after employment in the current industry (11). However, according to Ameille et al (9) role of genetics lacks consistency in being reported as a significant factor.…”

Section: Discussionmentioning

confidence: 86%

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Prevalence and correlates of asthma among selected garment factory workers at the Free Trade Zone, Ekala

Jayawardana

Abeysena

2016

J Coll Community Phys Sri Lanka

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ObjectiveTo determine prevalence of bronchial asthma (BA) and its correlates and respiratory functions among selected garment factory workers (GFW) at the Free Trade Zone, Ekala. MethodsThis consisted of a cross sectional descriptive and an analytical study. It was conducted at three selected garment factories and a clinic setting in Ekala. Study group for first component included 674 GFW who have worked for 1 or more years at the current garment factories. Control group for second component included 100 participants who have never worked in garment factories. Study instruments consisted of an interviewer administered questionnaire and spirometry. Bivariate analysis was followed by multiple logistic regressions. Results were expressed as odds ratios (OR) and 95% Confidence intervals (CI). ResultsOverall prevalence of BA among GFW was 32.3% (95% CI:28.8-36.0%). Prevalence of "probable occupational asthma" among asthmatic GFW was 49.5% (95% CI:42.7-56.4%). Being a GFW (OR=3.5, 95% CI:1.9-7.2) and age >30 years (OR=1.5; 95% CI:1.1-2.1) were significantly associated with prevalence of BA. Among GFW, FEV1.0 and PEFR were significantly lower among asthmatics compared to non asthmatics, and FVC, FEV1.0, and PEFR among those exposed to dust for >3 years compared to ≤3 years. ConclusionsPrevalence of bronchial asthma was higher among Garment Factory Workers. However, respiratory functions were lower only among those who were asthmatics.

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 86%

Prevalence and correlates of asthma among selected garment factory workers at the Free Trade Zone, Ekala

Jayawardana

Abeysena

2016

J Coll Community Phys Sri Lanka

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“…The levels of allergen in these workplaces were not associated with primary outcomes: sensitization, symptoms, asthma, or BHR. Asthma, defined by symptoms and a positive bronchial challenge test, showed no increased prevalence as compared with other prevalence studies in this country and region 20) . The lack of association between exposure and asthma may be consequence of the healthy worker effect, as discussed below.…”

Section: Discussionmentioning

confidence: 71%

Study of risk factors for atopic sensitization, asthma, and bronchial hyperresponsiveness in animal laboratory workers

Simoneti

Freitas

Barbosa

et al. 2016

Journal of Occupational Health

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al.: Animal laboratory workers: risks for allergy and asthma associated with sensitization, asthma, or BHR. Conclusion: Exposure to laboratory animals was associated with atopic sensitization. However, we did not find a cutoff allergen concentration that increased the risk for sensitization. Duration of exposure seems to be more relevant to sensitization than concentration of allergens in dust. (J Occup Health 2016; 58: 7−15) Key words: Animal experimentation, Atopy, Bronchial hyperreactivity, Occupational disease Workers exposed to laboratory animals have a high risk of developing allergic reactions 1,2) . Rats and mice are the most common etiology of laboratory animal allergy because they are the most commonly used animals in research 3) . The high prevalence of this condition became evident from epidemiological crosssectional studies conducted in the 1980s 1,4) . Eleven to 44% of individuals who work with laboratory animals have reported allergic symptoms. These symptoms can range from skin reactions, nasal congestion, rhinorrhea, sneezing, and conjunctivitis, to severe asthma. Allergic rhinitis and allergic conjunctivitis symptoms are the most commonly reported symptoms. Among workers who become symptomatic, 4 to 22% have occupational asthma 2) . In a cohort study of 342 laboratory animal workers, quantitative analyses of exposure demonstrated a doseresponse relation between the intensity of exposure to skin symptoms and skin prick tests. Intensity of exposure (divided into 4 categories) was evaluated by quantification of rat urinary aeroallergen. Exposureresponse relations for symptoms were observed among sensitized workers, and for chest and eye/nose symptoms, they were not as clear as for skin symptoms. Two exposure indices were created: one based on the The aim of this estudy was to investigate the influence of allergen exposure levels and other risk factors for allergic sensitization, asthma, and bronchial hyperresponsiveness (BHR) in workers exposed to laboratory animals. Methods: This was a crosssectional study performed at two universities, 123 workplaces with 737 subjects. Dust samples were collected from laboratories and animal facilities housing rats, mice, guinea pigs, rabbits, or hamsters and analyzed by enzyme-linked immunosorbent assay (ELISA) to measure allergen concentrations. We also sampled workplaces without animals. Asthma was defined by both symptoms and BHR to mannitol. The concentrations of allergens were tested for association with a skin prick test, respiratory symptoms, spirometry data, and BHR. This multivariate analysis was performed by using Poisson regression to estimate the relative risk (RR) for the exposed group. Results: Our sample comprised students and workers, with 336 subjects in the nonexposed group and 401 subjects in the exposed group. Sixty-nine subjects (17%) had positive results in the skin prick test for animal allergens in the exposed group; in the nonexposed group, 10 subjects had positive results (3%) (p<0.001). Exposure to laboratory animals over 2.8 years...

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“…Some of these analyses have already been published. [7][8][9][10] The tests and measurements were carried out in a healthcare setting with easy access to medical facilities. The examinations were performed at the university hospital in the city of Ribeirão Preto, in the northwestern region of the state of São Paulo, Brazil.…”

Section: Samplementioning

confidence: 99%

“…8 The ECRHS questionnaire was developed for use among young adults aged 20 to 44 years, to explore asthma symptoms in young adults. We used questions of the ECRHS questionnaire to explore asthma symptoms.…”

Section: Respiratory and Occupational Questionnairesmentioning

confidence: 99%

Accuracy of spirometry for detection of asthma: a cross-sectional study

Meneghini

Paulino

Pereira³

et al. 2017

Sao Paulo Med. J.

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BACKGROUND: Asthma is a chronic inflammatory disease with airway hyperresponsiveness. Spirometry is the most commonly used test among asthmatic patients. Another functional test used for diagnosing asthma is the bronchial challenge test. The aim of this study was to analyze the accuracy of spirometry for detecting asthma in the general population. DESIGN AND SETTING: Cross-sectional study with data analysis to evaluate the accuracy of spirometry through calculating sensitivity, specificity and predictive values and through the kappa agreement test. METHODS: Subjects who constituted a birth cohort were enrolled at the age of 23 to 25 years. Spirometric abnormality was defined as reduced forced expiratory volume in one second, i.e. lower than 80% of the predicted value. Measurement of bronchial responsiveness was performed by means of the bronchial challenge test with methacholine. The gold-standard diagnosis of asthma was defined as the presence of bronchial hyperresponsiveness in association with respiratory symptoms. RESULTS: Asthma was detected in 200 subjects (10.4%) out of the sample of 1922 individuals. Spirometric abnormality was detected in 208 subjects (10.9%) of the sample. The specificity of spirometric abnormality for detecting asthma was 90%, sensitivity was 23%, positive predictive value was 22%, and negative predictive value was 91%. The kappa test revealed weak agreement of 0.13 (95% confidence interval, CI: 0.07-0.19) between spirometry and the diagnosis of asthma. CONCLUSION: Spirometry, as a single test, has limitations for detecting asthma in the general population.

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Prevalence and risk factors for work related asthma in young adults

Abstract: The prevalence of work related asthma was high (4.2%), and was associated with low schooling, probably because of low socioeconomic level. The disease may therefore be a consequence of poverty.

Cited by 45 publications

References 46 publications

Prevalence and correlates of asthma among selected garment factory workers at the Free Trade Zone, Ekala

Prevalence and correlates of asthma among selected garment factory workers at the Free Trade Zone, Ekala

Study of risk factors for atopic sensitization, asthma, and bronchial hyperresponsiveness in animal laboratory workers

Accuracy of spirometry for detection of asthma: a cross-sectional study

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