Prevalence and predictors of dyslipidemia among hypertensive patients in Lumame Primary Hospital, Amhara, Ethiopia: A cross-sectional study

Kifle, Zemene Demelash; Alehegn, Agumas Alemu; Adugna, Meaza; Bayleyegn, Biruk

doi:10.1016/j.metop.2021.100108

Cited by 13 publications

(18 citation statements)

References 67 publications

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“…From the results of the present study, at least 50% of the study participants were at increased risk of cardiovascular events due to dyslipidaemia. A similar high prevalence of dyslipidaemia has been reported in other African countries among people living with DM and hypertension [38][39][40]. The lack of screening and management of dyslipidaemia in the present study highlights the gap in addressing the burden associated with dyslipidaemia in high-risk individuals with DM and hypertension in Malawi, hence contributing to the high burden associated with CVDs [34].…”

Section: Discussionsupporting

confidence: 78%

High prevalence of dyslipidaemia among persons with diabetes mellitus and hypertension at a tertiary hospital in Blantyre, Malawi

Katundu

Mukhula

Phiri

et al. 2022

BMC Cardiovasc Disord

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Background Dyslipidaemia drives the process of atherosclerosis, and hence a significant modifiable risk factor complicating hypertension and diabetes. In Malawi, the prevalence, screening and management of dyslipidaemia among persons with diabetes mellitus have not been reported. This study aimed to investigate the prevalence, biochemical characteristics, screening and management practices for dyslipidaemia among persons with diabetes mellitus, hypertension, and diabetes mellitus and hypertension comorbidity at Queen Elizabeth Central hospital in Blantyre, Malawi. Methods This was a cross-sectional study conducted in 2021. A total of 256 adult participants (diabetes mellitus = 100); hypertension = 100; both conditions = 56) were included. Medical data and anthropometric measurements were recorded. Blood samples were analysed for HbA1C and serum lipids. Associated risk factors for dyslipidaemia were also assessed. Results Dyslipidaemia was prevalent in 58%, 55%, and 70% of participants with diabetes mellitus, hypertension, and both conditions. Low-density lipoprotein cholesterol (LDL-C) dyslipidaemia was the most common in all participant groups. Participants with both diabetes and hypertension had 2.4 times (95% CI 1.2–4.6) increased risk of LDL-C dyslipidaemia than those with diabetes alone (p < 0.02). Being overweight or obese and age over 30 years were risk factors for dyslipidaemia in participants with diabetes mellitus alone (OR 1.3 (95% CI 1.1–1.6), p < 0.04, and OR 2.2 (95% CI 1.2–4.7) (p < 0.01), respectively. Overweight and obesity predicted LDL-C dyslipidaemia in hypertensive patients (OR 3.5 (95% CI 1.2–9.9) p < 0.001). Poorly controlled hypertension and the use of beta-blockers and thiazide diuretics predicted dyslipidaemia among patients with both diabetes mellitus and hypertension (OR 6.50 CI 1.45–29.19; and OR 5.20 CI 1.16–23.36 respectively). None of the participants had a lipogram performed before the study or were on lipid-lowering therapy. Conclusions Dyslipidaemia with LDL-C derangement was highly prevalent, especially in individuals with both diabetes mellitus and hypertension, and there was absent use of lipid-lowering therapy. Screening and managing dyslipidaemia should be reinforced to reduce the risk of cardiovascular complications in this population at increased risk.

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Section: Discussionsupporting

confidence: 78%

High prevalence of dyslipidaemia among persons with diabetes mellitus and hypertension at a tertiary hospital in Blantyre, Malawi

Katundu

Mukhula

Phiri

et al. 2022

BMC Cardiovasc Disord

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“…In accordance with our observations, findings from a study depicted HDL as the most common lipid abnormality as well as physical activity status was observed to be the crucial determinant of the development of dyslipidemia [ 35 ]. However, in contrast to our outcome, a strong direct correlation of HbA1c was observed between reduced HDL levels and elevated BMI among the subjects of diabetic dyslipidemia [ 36 ].…”

Section: Discussionsupporting

confidence: 90%

Risk Analysis and Assessment of Lipid Abnormalities as the Earliest Complication in Newly Diagnosed Diabetic and Non-Diabetic Individuals of a Local Population

et al. 2022

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Lipid variations have been frequently observed in global populations that can affect health status. Mainly studies have been conducted on the type 2 diabetic population, but limited data is available on newly diagnosed ones to unravel complications and risk predictors independent of disease progression. This study comprising 244 individuals was carried out to assess the lipid abnormalities in newly diagnosed diabetics and non-diabetics. The clinical and socio-demographic data were collected and analyzed using independent samples t-test and linear regression. Serum lipid variations were observed individually and in combination. The individuals in group I (diabetics with dyslipidemia) revealed elevated levels of low-density lipoprotein and serum triglycerides higher than in group II (non-diabetics with dyslipidemia). The frequency of deranged total cholesterol in group I was observed to be higher than in group II. Independent samples t-test showed a significant mean difference in variables between the two groups. Linear regression analysis showed a significant variable outcome for predictors between high-density lipoprotein (HDL) and physical activity (B= −0.043, 95% CI: −0.80, −0.006) and total cholesterol (TC) with family history (B= −0.062, 95% CI: −0.123, −0.001). The findings conclude that lipid levels deranged independently regardless of type 2 diabetes mellitus and present as an early onset in type 2 diabetes instead of later stage complication. These derangements of lipid levels are an independent risk factor for future cardiovascular pathology.

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“…A number of risk factors were linked to dyslipidemia among hypertension patients, according to empirical data from earlier literature. These risk variables included sedentary behavior, age, gender, obesity, smoking, diabetes, and a poor diet of fruits and vegetables [ 27 , 28 ]. Although non-healthy food and people’s behaviors are linked to roughly 80% of dyslipidemia [ 29 ], this percentage is still high.…”

Section: Introductionmentioning

confidence: 99%

“…Although non-healthy food and people’s behaviors are linked to roughly 80% of dyslipidemia [ 29 ], this percentage is still high. In addition, Kifle Z et al and Hirigo A et al, respectively, observed high rates of dyslipidemia among Ethiopian hypertensive patients (48.4% and 90.8%) [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Evidence suggested that the rising prevalence of atherogenic dyslipidemia and hypertension in patients may significantly deteriorate their state of health [ 10 , 12 , 30 , 31 ]. In the majority of developing nations, including Ethiopia, CVD-related diseases and hypertension have recently become major public health issues [ 3 , 4 , 27 ]. There were few data on the prevalence of dyslipidemia and related variables in hypertension patients in Ethiopia, despite its high prevalence and related complication in this population.…”

Section: Introductionmentioning

confidence: 99%

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Atherogenic dyslipidemia and associated risk factors among hypertensive patients of five health facilities in Northeast Ethiopia

et al. 2023

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Background One of the major risk factors for cardiovascular disease is atherogenic dyslipidemia. There was, however, little information available in Ethiopia. Therefore, the purpose of this study was to estimate the prevalence of atherogenic dyslipidemia and related risk factors in Northeast Ethiopian hypertension patients. Materials and methods A systematic random sampling technique was used to perform a cross-sectional study at an institution with 384 chosen participants. A structured questionnaire was used to collect the socio-demographic, anthropometric, lifestyle, and clinical characteristics of the respondents. Student’s t-test, Mann-Whitney test, and Pearson’s Chi-square test were employed to compare groups based on the type of data. Furthermore, Bivariate and multivariable logistic regression analyses were performed to identify factors independently associated with dyslipidemia. Crude and adjusted odds ratios and their corresponding 95% Confidence Intervals (CI) were computed. In all cases, statistical significance was declared at p <0.05. Results The majority (93.2%; 95%CI: 90.6–95.6) of patients had at least one atherogenic dyslipidemia. The prevalence of elevated total cholesterol (TC), elevated triglyceride (TG), raised low-density lipoprotein cholesterol (LDL-c), and reduced high-density lipoprotein cholesterol (HDL-c) were 47.7%, 50.3%, 44.3%, and 59.6%, respectively. Being≥ 40 years were at higher risk for having elevated levels of TC (AOR: 3.22, 95% CI: 2.40–4.32), TG (AOR: 2.30, 95% CI: 1.61–3.79), and LDL-c (AOR: 4.68, 95% CI: 2.0–10.95) than those who were below 40years. Obese participants were more likely to have high concentrations of TC (AOR: 2.57, 95%CI: 2.10–3.22), LDL-c (AOR: 3.13, 95% CI: 1.97–5.10), HDL-c (AOR: 2.71, 95% CI: 1.77–4.58), and TG (AOR: 2.23, 95%CI: 1.79–4.16). Conclusion This study revealed that a high prevalence of atherogenic dyslipidemia. Thus, to prevent atherogenic dyslipidemia, it is crucial to create routine blood lipid testing programs and carry out suitable intervention programs focused on risk factor reduction.

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Prevalence and predictors of dyslipidemia among hypertensive patients in Lumame Primary Hospital, Amhara, Ethiopia: A cross-sectional study

Cited by 13 publications

References 67 publications

High prevalence of dyslipidaemia among persons with diabetes mellitus and hypertension at a tertiary hospital in Blantyre, Malawi

High prevalence of dyslipidaemia among persons with diabetes mellitus and hypertension at a tertiary hospital in Blantyre, Malawi

Risk Analysis and Assessment of Lipid Abnormalities as the Earliest Complication in Newly Diagnosed Diabetic and Non-Diabetic Individuals of a Local Population

Atherogenic dyslipidemia and associated risk factors among hypertensive patients of five health facilities in Northeast Ethiopia

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