Zn2+ is an essential regulator of coagulation and is released from activated platelets. In plasma, free Zn2+ concentration is fine-tuned through buffering by human serum albumin (HSA). Importantly, the ability...
HighlightsA molecular mechanism underlying the albumin-cobalt binding assay.Free fatty acid binding interferes with Co(II) binding to albumin.Ischemia-modified albumin corresponds to albumin with increased FFA bound.Increased FFA levels are sufficient to explain high ACB readings.Clinical data are consistent with FFA as the trigger for high ACB/high IMA levels.
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