Prevalence and genotype distribution of human papillomavirus in women with cervical cancer or high‐grade precancerous lesions in Chengdu, western China

Li, Jinke; Zhang, Dan; Zhang, Yi; Wang, Xia; Lin, Yong; Hu, Lina

doi:10.1016/j.ijgo.2010.08.010

Cited by 23 publications

(27 citation statements)

References 15 publications

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“…However, to our knowledge, HPV-58 was detected more frequently in some areas of China, supporting diversified and geographic variations of HPV distribution (1-4). Our recent study found that HPV-58 was the second most prevalent genotype in cervical carcinoma in western China (8). In the present study, we further verified that in this area, HPV-58 is the second most prevalent genotype in CIN patients, which could be detected in over one-fifth of CIN lesions.…”

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confidence: 87%

“…However, HPV genotype prevalence varies in different countries or regions. In a previous study, we reported a high prevalence of HPV-16 and -58 in cervical carcinoma patients in western China, suggesting HPV genotype distribution may be quite different from other regions in the world (8). In the present study, we further investigated HPV type-specific prevalence in CIN lesions in a much larger patient population.…”

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confidence: 76%

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Human Papillomavirus Type-Specific Prevalence in Women with Cervical Intraepithelial Neoplasm in Western China

Mei

Wang

et al. 2012

J Clin Microbiol

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Human papillomavirus (HPV) type-specific prevalence was studied in 600 cases of cervical intraepithelial neoplasm in western China by GenoArray test. HPV-16 and -58 were the most prevalent types, with prevalences of 37.8% and 21.8%, respectively. HPV-18 and -45 were uncommon types. The results show different type distributions from that of other regions, which is important evidence for the selection of future genotypes in HPV vaccines in western China. Cervical carcinoma is one of the most common malignancies that affect women worldwide. It is developed from a series of precancerous lesions called cervical intraepithelial neoplasm (CIN; graded from 1 to 3). Human papillomavirus (HPV) infection, the most important risk factor for cervical cancer development, can be detected in over 95% of carcinoma tissues (10). More than 100 different HPV genotypes are sequenced, of which about 15 types are called high-risk HPV because of their strong carcinogenic potentials (12). One important approach to prevent cervical cancer and CIN is the prevention of HPV infection by prophylactic vaccination. The currently available HPV vaccines are mainly against HPV-16 and -18 types, since they are the most important genotypes globally (7). However, HPV genotype prevalence varies in different countries or regions. In a previous study, we reported a high prevalence of HPV-16 and -58 in cervical carcinoma patients in western China, suggesting HPV genotype distribution may be quite different from other regions in the world (8). In the present study, we further investigated HPV type-specific prevalence in CIN lesions in a much larger patient population.A total of 600 histologically diagnosed patients with CIN (CIN1, 143 cases; CIN2, 181 cases; and CIN3, 276 cases) were included. These patients visited West China Second Hospital, Sichuan University, one of the largest medical centers in western China, from January 2010 to March 2011. The histological diagnosis was verified by two independent pathologists who were blinded of the HPV status. Cast-off cells were scraped from cervical lesions by using plastic swabs and stored in physiological saline at 4°C until further use. Cervical samples were used for HPV DNA detection and genotyping by GenoArray test (Hybribio Limited, Hong Kong, China) as described previously (9). This kit can simultaneously identify 21 HPV genotypes, including 7 low-risk types (types 6, 11, 42, 43, 44, 53, and 81) and 14 high-risk genotypes (types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68). Cochran-Armitage trend tests were used, and P values of Ͻ0.05 were considered significant. The attributable fraction of each genotype was estimated, and 95% confidential intervals (CI) were calculated as described before (6).In the 600 CIN patients, the overall HPV infection rate was 80.8%, while that of the high-risk HPV type was 75.8%. As for the types, HPV-16 was the one most frequently found, with a prevalence of 37.8% and an attributable fraction of 34.2%. HPV-58 was the second most common genotype, which was det...

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Human Papillomavirus Type-Specific Prevalence in Women with Cervical Intraepithelial Neoplasm in Western China

Mei

Wang

et al. 2012

J Clin Microbiol

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“…The reports on HPV infection in patients with CIN in the Western China are scarce, and the sample sizes of these studies are nonrepresentative. [15–17] Thus, to develop reasonable screening and treatment plans for patients with HPV infections in the Western China, as well as provide evidence for the development of preventive and therapeutic HPV vaccines, we treated patients with cervical precancerous lesions admitted in our hospital from January 2016 to August 2016 as our study subjects and analyzed their HPV infection subtypes. The study demonstrated the following results: the overall HPV infection rate was 82.58%, and the high-risk HPV infection rate was 76.61%.…”

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confidence: 99%

Analysis of HPV distribution in patients with cervical precancerous lesions in Western China

Yin²,

Li³

et al. 2017

Medicine

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Cervical human papillomavirus (HPV) infection is a dangerous disease, whose subtypes exhibit different distribution patterns in particular countries, regions, and races. In this study, the HPV distribution in patients with cervical precancerous lesions in Western China was investigated to assess a probability for prevention of cervical cancer and the clinical application of an HPV vaccine in China. The retrospective study of patients with different HPV subtypes and cervical precancerous lesions, who have undergone loop eelectrosurgical excision procedure, cold knife conization, or a total hysterectomy in our hospital from January 2016 to August 2016, was performed. All patients were tested for 27 HPV subtypes via the liquid suspension chip technology (Luminex 200). A total of 3393 cases of cervical intraepithelial neoplasia (CIN) were investigated, including 1098 cases of CIN I, 762 cases of CIN II, and 1533 cases of CIN III. The overall HPV infection rate was 82.58%. The high-risk HPV infection rate was 76.61%, and the low-risk rate was 9.88%. The most common 5 subtypes were HPV16, HPV52, HPV58, HPV33, and HPV18. The patients were grouped into 6 age groups: ≤20, 21 to 30, 31 to 40, 41 to 50, 50 to 64, and ≥65. The HPV subtypes’ distribution varied across different age groups. In patients with cervical precancerous lesions in Western China, the top 5 HPV subtypes with the highest infection rates were HPV16, HPV52, HPV58, HPV33, and HPV18. The rate of cervical precancerous lesions unrelated to HPV was 17.42%. Thus, HPV screening with no cytology may leave unobserved about 20% of cervical precancerous lesions, which is worth of significant clinical attention.

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“…For example, HPV16 is slightly more prevalent in Europe and North America, HPV 31 is more prevalent in South/Central America, HPV 33 and 45 are more prevalent in Africa, and HPV 52 and 58 are more prevalent in Asia [9, 11–17]. Furthermore, the data from mainland China indicated that HPV16, 18, 33, and 58 were the most common types in women with CC in Henan, central China [18], whereas HPV16, 58, 18 and 33 were the most prevalent types in CIN2+ (high-grade cervical lesions, including CINII/III, and CC) in women in Liaoning, northeast China [19], and HPV16 and 58 were the most common types in CC and high-grade precancerous lesions in Chengdu, southwestern China [20]. …”

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confidence: 99%

Human papillomavirus genotypes associated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China

Guo

Wang²,

et al. 2017

Infect Agents Cancer

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BackgroundThe mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China.MethodsBetween 2012 to 2016, 329 samples with cervicitis, cervical intraepithelial neoplasia grade 1 to 3 (CINI to III), and invasive squamous cell carcinoma (SCC) were collected. HPV genotypes were examined with a validated kit for 23 different HPV subtypes.ResultsCompared to cervicitis, the HPV positivity is significantly higher in CINI, CIN II/III, and SCC (38.60%, 74.60%, 87.50% and 89.05%, P < 0.001) and the positivity is also higher in SCC compared to CINI (P < 0.01). The most frequently detected genotypes were HPV16 in cervicitis, HPV16, 58 and 52 in CINI and CIN II/III, and HPV16, 58 and 18 in SCC groups. HPV16 positivity in cervicitis, CINI, CIN II/III, and SCC patients were 45.46%, 46.81%, 60.32% and 78.69%, respectively. Compared to cervicitis and CINI, the odds ratios (OR) for SCC in HPV16 positive patients were 2.96 (95% confidence interval [CI]: 1.09–8.00, P < 0.05) and 4.20 (95% confidence interval [CI]: 2.05–8.61, P < 0.001), respectively. In addition, the multiple infections in cervicitis, CINI, CINII/III and SCC group are 9.09%, 27.66%, 26.98% and 25.41% and HPV16 + 58 was the most common combinations.ConclusionThese findings highlight the key role of HPV16, 58, 52 and 18 in the development of CIN and SCC in Longnan women and a fully aware of regional differences in HPV genotype distribution are tasks for cervical cancer control and prevention.

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Prevalence and genotype distribution of human papillomavirus in women with cervical cancer or high‐grade precancerous lesions in Chengdu, western China

Abstract: The prevalence of HPV-16 and HPV-58 was high. This finding may help to improve HPV vaccination and cervical cancer prevention programs in western China.

Cited by 23 publications

References 15 publications

Human Papillomavirus Type-Specific Prevalence in Women with Cervical Intraepithelial Neoplasm in Western China

Human Papillomavirus Type-Specific Prevalence in Women with Cervical Intraepithelial Neoplasm in Western China

Analysis of HPV distribution in patients with cervical precancerous lesions in Western China

Human papillomavirus genotypes associated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China

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