Analysis of HPV distribution in patients with cervical precancerous lesions in Western China

Abstract

Cervical human papillomavirus (HPV) infection is a dangerous disease, whose subtypes exhibit different distribution patterns in particular countries, regions, and races. In this study, the HPV distribution in patients with cervical precancerous lesions in Western China was investigated to assess a probability for prevention of cervical cancer and the clinical application of an HPV vaccine in China. The retrospective study of patients with different HPV subtypes and cervical precancerous lesions, who have undergone loop eelectrosurgical excision procedure, cold knife conization, or a total hysterectomy in our hospital from January 2016 to August 2016, was performed. All patients were tested for 27 HPV subtypes via the liquid suspension chip technology (Luminex 200). A total of 3393 cases of cervical intraepithelial neoplasia (CIN) were investigated, including 1098 cases of CIN I, 762 cases of CIN II, and 1533 cases of CIN III. The overall HPV infection rate was 82.58%. The high-risk HPV infection rate was 76.61%, and the low-risk rate was 9.88%. The most common 5 subtypes were HPV16, HPV52, HPV58, HPV33, and HPV18. The patients were grouped into 6 age groups: ≤20, 21 to 30, 31 to 40, 41 to 50, 50 to 64, and ≥65. The HPV subtypes’ distribution varied across different age groups. In patients with cervical precancerous lesions in Western China, the top 5 HPV subtypes with the highest infection rates were HPV16, HPV52, HPV58, HPV33, and HPV18. The rate of cervical precancerous lesions unrelated to HPV was 17.42%. Thus, HPV screening with no cytology may leave unobserved about 20% of cervical precancerous lesions, which is worth of significant clinical attention.

The distribution and prevalence of human papillomavirus in women in mainland China

“…The cervical HPV infection rate in patients with cervical lesions is significantly higher than that of the general population and is significantly region‐related . The present study systematically analyzed the high‐risk HPV infections in patients with cervical intraepithelial neoplasia and cervical cancer in different regions of mainland China.…”

“…Persistent infection with high‐risk human papillomavirus (HPV) is the primary cause of cervical cancer. Our group analyzed HPV infections in patients with cervical cancer or precancerous cervical lesions and found that 90.8% of cervical cancer patients were infected with high‐risk HPVs, and the 5 subtypes of high‐risk HPV with the highest infection rate were 16, 18, 58, 53, and 33; 76.6% of patients with precancerous cervical lesions were infected with high‐risk HPVs, and the top 5 infectious subtypes were 16, 52, 58, 33, and 18 . Studies have shown that HPV subtypes have significant age and regional specificities, which differed in different levels of precancerous cervical lesions and cervical cancer .…”

Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis

“…(4) The total case number of each category and HR-HPV infection. 15 types of HR-HPV types were collected, namely, HPV 16,18,31,33,35,39,45,51,52,56,58,59,68,73,82, and other probable high-risk types (e.g., HPV 53, 66, and83). (5) Area: Given the geographical distribution, the areas involved in this study are divided into East China (i.e., Shanghai, Jiangsu, Zhejiang, Anhui, Jiangxi, Shandong, Fujian, and Taiwan province), North China (i.e., Beijing, Tianjin, Shanxi, Hebei, and Central Inner Mongolia Autonomous Region), Central China (i.e., Henan, Hubei, and Hunan province), South China (i.e., Guangdong, Guangxi Zhuang Autonomous Region, Hainan province, the Hong Kong Special Administrative Region, and Macao Special Administrative Region), Southwest China (i.e., Chongqing, Sichuan, Guizhou, Yunnan Province, and the Tibet Autonomous Region), Northwest China (i.e., Shanxi, Gansu, Qinghai, Ningxia Hui Autonomous Region, Xinjiang Uygur Autonomous Region, Inner Mongolia Autonomous Region, and West La Shan Au), and Northeast China (i.e., Heilongjiang, Jilin, Liaoning, and East of Inner Mongolia).…”

“…Articles for Northeast China, North China, East China, South China, Central China, Northwest China, Southwest Chinawere obtained. A total of eight HR-HPV genotypes (i.e., HPV 16,18,31,33,52,58,59, and 68) of cervical cancer were selected by synthetically analyzing the top five high-risk types of cervical cancer in different regions. Figure 3).…”

“…The HPV infection rate and distribution of HPV subtypes vary in different countries and regions. Infection of high-risk HPV (HR-HPV) infection (e.g., HPV 16,18,31,and 45) is the main cause of the occurrence and development of cervical cancer. Although the important HR-HPV types (e.g., HPV l6 and 18) show consistency in the geographic area distribution, the main HPV subtypes differ in different parts of the world [2,3].…”