Prevalence and Correlates of Erectile Dysfunction in Turkey: A Population-Based Study

Akkuş, Emre; Kadıoğlu, Ateş; Esen, Adil; Doran, Saban; Ergen, Ali; Anafarta, Kadri; Hattat, Halim

doi:10.1016/s0302-2838(02)00027-1

Cited by 234 publications

(240 citation statements)

References 23 publications

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“…32 In a population-based study conducted to determine the prevalence of ED in Turkey, it was found that low educational level of the patients was associated with ED. 34 A strong association was detected between anxiety and PE, 35,36 but depression was not found to be a risk factor for PE. 33,37 In this study, anxiety level was significantly higher in AS patients, which may also be a determining factor for PE.…”

Section: Discussionmentioning

confidence: 93%

Sexual function in male patients with ankylosing spondylitis

et al. 2011

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Section: Discussionmentioning

confidence: 93%

Sexual function in male patients with ankylosing spondylitis

et al. 2011

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“…Our initial search identified 221 articles, but only 11 cross-sectional studies [13][14][15][16][17][18][19][20][21][22] documented the adjusted OR for alcohol, another cross-sectional study 23 and a prospective cohort 24 from the same study population provided adjusted relative risks (RR), one cohort study 25 provided adjusted OR. Only the 11 cross-sectional studies that provided adjusted ORs will be included in the meta-analysis, since the other two cohort studies were of different study design, and the RR reported by the cross-sectional and cohort studies were derived with a different statistical method (Mantel-Haenszel rather than logistic regression).…”

Section: Resultsmentioning

confidence: 99%

“…Alcohol consumption and erectile dysfunction JYW Cheng et al (95% CI, 12-22), 16% (11-23) and 15% (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) in those with o1 drink/day, 1-3 drinks/day and X4 drinks/day of alcohol consumption respectively. This incidence figure was adjusted for age, active and passive smoking, overweight, hypertension, physical activity, cholesterol, fat intake, testosterone, depression and antihypertensive medication intake.…”

Section: Cohort Study (Mmas)mentioning

confidence: 99%

Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies

et al. 2007

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Alcohol is long regarded as a risk factor for erectile dysfunction (ED), but epidemiological evidence has been equivocal. We aimed to investigate the ED risk associated with various levels of alcohol consumption by meta-analysis. We searched for population-based studies on ED through Medline, PubMed, PsychInfo, and scanned through reference lists. Eleven cross-sectional studies were included and analyzed with random effects model. We reviewed the results from one crosssectional study and two cohort studies. Regular alcohol consumption was negatively associated with ED (odds ratio (OR) ¼ 0.79; 99% confidence interval (CI), 0.67-0.92; Po0.001). Consumption of 8 or more drinks/week significantly reduced the risk of ED (OR ¼ 0.85; 99% CI, 0.73-0.99; P ¼ 0.007), but consumption of less alcohol (1-7 drinks/week) was not significant (OR ¼ 0.73; 99% CI, 0.44, 1.20; P ¼ 0.101). Begg's test and Egger's test detected no significant publication bias. Our estimates (in sensitivity analyses) were rendered nonsignificant when International Index of Erectile Function definition was used and when statistical adjustment was made only for age. Meta-analysis of crosssectional studies yielded a protective association of alcohol on ED, but the two cohort studies did not demonstrate any significant findings for alcohol consumption. More research is needed to confirm whether alcohol is protective or is unrelated to ED development.

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“…21 A sedentary lifestyle increases ED by 2-10-fold, 22-24 whereas 'moderate' activity has been reported to reduce ED by two-thirds and 'high' activity by over 80% (unfortunately, these degrees of activity were not defined). 25 Because penile blood flow presumably does not increase with physical exercise, the principal mechanism whereby physical exercise improves ED may be the pronounced effect of increased systemic NO on glucose disposal and insulin sensitivity (reviewed above). However, physical exercise also increases PON-1 activity, 26 a circulating HDL-associated antioxidant enzyme reported to be lower in men with ED.…”

Section: Exercisementioning

confidence: 99%

Lifestyle and metabolic approaches to maximizing erectile and vascular health

et al. 2011

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Oxidative stress and inflammation, which disrupt nitric oxide (NO) production directly or by causing resistance to insulin, are central determinants of vascular diseases including ED. Decreased vascular NO has been linked to abdominal obesity, smoking and high intakes of fat and sugar, which all cause oxidative stress. Men with ED have decreased vascular NO and circulating and cellular antioxidants. Oxidative stress and inflammatory markers are increased in men with ED, and all increase with age. Exercise increases vascular NO, and more frequent erections are correlated with decreased ED, both in part due to stimulation of endothelial NO production by shear stress. Exercise and weight loss increase insulin sensitivity and endothelial NO production. Potent antioxidants or high doses of weaker antioxidants increase vascular NO and improve vascular and erectile function. Antioxidants may be particularly important in men with ED who smoke, are obese or have diabetes. Omega-3 fatty acids reduce inflammatory markers, decrease cardiac death and increase endothelial NO production, and are therefore critical for men with ED who are under age 60 years, and/or have diabetes, hypertension or coronary artery disease, who are at increased risk of serious or even fatal cardiac events. Phosphodiesterase inhibitors have recently been shown to improve antioxidant status and NO production and allow more frequent and sustained penile exercise. Some angiotensin II receptor blockers decrease oxidative stress and improve vascular and erectile function and are therefore preferred choices for lowering blood pressure in men with ED. Lifestyle modifications, including physical and penile-specific exercise, weight loss, omega-3 and folic acid supplements, reduced intakes of fat and sugar, and improved antioxidant status through diet and/or supplements should be integrated into any comprehensive approach to maximizing erectile function, resulting in greater overall success and patient satisfaction, as well as improved vascular health and longevity.

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Prevalence and Correlates of Erectile Dysfunction in Turkey: A Population-Based Study

Cited by 234 publications

References 23 publications

Sexual function in male patients with ankylosing spondylitis

Sexual function in male patients with ankylosing spondylitis

Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies

Lifestyle and metabolic approaches to maximizing erectile and vascular health

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