Few studies have investigated personality characteristics in people with multiple sclerosis (MS), and little is known about the relationship between personality and clinical characteristics in these patients. We aimed to investigate the personality traits of MS patients and their relationship with clinical characteristics. The study population consisted of 74 MS patients and age-matched, sex-matched, and education level-matched healthy controls. All participants were instructed to complete the self-administered 240-item Temperament and Character Inventory and the Beck Depression Inventory. The MS patients exhibited higher harm avoidance (HA) and lower self-directedness scores than the control group, although these differences disappeared after controlling for depression. Duration of the disease was positively correlated with HA and negatively correlated with novelty-seeking scores. Expanded Disability Status Scale scores were negatively correlated with reward dependence. Our results suggest a possible relationship between personality characteristics and the stage of the disease or the degree of damage in MS patients.
Akut mani nöbetinde nitrik oksit ve asimetrik dimetilarjinin düzeyleri Amaç: İki uçlu duygudurum bozukluklarının (İDB) biyokimyasal boyutu üzerine olan çalışmalar yakın zamanda artış göstermiştir. Nitrik oksitin (NO) ve NO'nun sistem içi baskılayıcısı olan asimetrik dimetil arginin (ADMA)'nin işlevi, duygudurum bozuklukları, şizofreni, otizm, obsesif kompulsif bozukluk ve Alzheimer hastalığında incelenmiş ve anlamlı sonuçlar bulunmuştur. Bu çalışmada, İDB duygudurum bozukluğu hastalarının akut mani dönemlerinde, plazma NO ve eş zamanlı plazma ADMA seviyelerinin sağlıklı kontrollerle karşılaştırılması amaçlanmıştır. Yöntem: Çalışmaya DSM-IV-TR'ye göre İDB-I mani nöbeti tanısı konulan 30 hasta alınmıştır. Sağlıklı kontrol grubu olarak hasta grubu ile yaş, cinsiyet, sigara kullanımı açısından eşleştirilmiş aynı sayıda kişi alınmıştır. Hasta grubuna tanı koymak, hasta ve çalışma gruplarında ilave ruhsal bozuklukları dışlamak için, SCID-I, hastalık şiddetini değerlendirmek için Hamilton Depresyon Ölçeği, Young Mani Ölçeği, Montgomery Asberg Değerlendirme Ölçeği kullanılmıştır. Çalışma ve kontrol grubundan, plazma NO seviyesi ve eş zamanlı ADMA seviyesi tayini için, 2 tüp plazma örneği alınmıştır. Sonuçlar: Hasta ve kontrol gruplarının plazma NO ve ADMA seviyeleri karşılaştırıldığında, hasta grubunda kontrol grubuna göre plazma NO seviyelerinin istatistiksel olarak anlamlı derecede düşük, ADMA seviyelerinin ise istatistiksel olarak anlamlı derecede yüksek olduğu bulunmuştur. Tartışma: Çalışmamız, İDB-I etiyopatogenezinde, NO'nun ve ADMA'nın işlevi ve karmaşık nörotransmitter sistemleri arasındaki ilişkiyi anlamaya katkıda bulunabilir.
Background and PurposeRestless legs syndrome (RLS) is a common sleep-related movement disorder that is frequently associated with psychological disturbances. Personality traits are of considerable importance with respect to coping with chronic illness and disease vulnerability. This study assessed the temperament and character traits of RLS patients using an approach that involves the psychobiological model of personality.MethodsThe personality features of 65 newly diagnosed and untreated RLS patients with no neurological or psychiatric diseases and 109 healthy controls were determined using the Temperament and Character Inventory and compared using covariance analyses. The International RLS Study Group Severity Scale was used to assess the severity of the RLS symptoms, and the Beck Depression Inventory was used to assess the presence and severity of depressive symptoms.ResultsRLS patients scored significantly higher than healthy controls on the temperament dimension of harm avoidance (HA, p=0.02) and significantly lower on self-directedness (SD, p=0.001). No significant difference was observed in terms of the temperament dimension of novelty seeking (p=0.435). HA scores were significantly correlated with the BDI score but not with the RLS severity or duration.ConclusionsHigh HA and low SD scores are the main characterizing personality features of RLS patients. These personality dimensions may be among the factors predisposing patients to development of the depressive symptoms that are frequently associated with RLS.
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