Prevalence and characterization of anaplastic large cell lymphoma and its association with Epstein-Barr virus in Pakistani patients

Noorali, Samina; Pervez, Shahid; Yaqoob, Nausheen; Moatter, Tariq; Nasir, Muhammad; Haroon, Saroona; Hodges, Elizabeth; Smith, Joan K.

doi:10.1016/j.prp.2004.08.004

Cited by 14 publications

(12 citation statements)

References 39 publications

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“…ALCL has been reported as positive for EBER in situ hybridization in 0% to 23% of cases in several studies [5,7,9,36,40,42]. However, none of the 13 cases of ALCL were positive in the present study, although 2 cases presented EBER expression that was limited to rare non-neoplastic lymphoid cells.…”

Section: Ptcl Nos -Peripheral T-cell Lymphoma Not Otherwise Specificontrasting

confidence: 65%

“…This challenging disease is diagnosed more frequently after the observation of aberrant CD10 expression on neoplastic T-cells [39]. Some EBV-positive cells were detected in 67-100% of the cases in previous studies and 62.5% of our cases [5,7,9,40,41]; however, the reaction with EBER was restricted to the reactive B-cell population, rather than neoplastic T-cells. While the latency pattern is unknown, LMP1 and EBERs reflect latency pattern II in these cases.…”

Section: Ptcl Nos -Peripheral T-cell Lymphoma Not Otherwise Specifimentioning

confidence: 50%

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Original paper Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization

Karaarslan¹,

Hekımgıl²,

Soydan³

et al. 2015

pjp

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Various racial and geographic differences have been observed in studies questioning the role of Epstein-Barr virus (EBV) infection in the etiology of T-and NK-cell lymphomas. The aim of this study was to evaluate the relationship of EBV with nodal or extranodal (skin excluded) T-and NK-cell lymphoma subtypes encountered in our geographic area. Sixty-two cases of peripheral T-cell lymphoma were included in the study. EBV-encoded early RNA (EBER) was detected by in situ hybridization. The distributions of T-and NK-cell lymphoma subtypes were as follows: 32 peripheral T-cell lymphomas, unspecified (PTCL, NOS), 13 anaplastic large-cell lymphomas (ALCL), 8 angioimmunoblastic T-cell lymphomas (AIT-CL), 4 extranodal NK/T-cell lymphomas, nasal type (NKTCL), 3 enteropathy-type T-cell lymphomas (ETTCL), 1 hepatosplenic T-cell lymphoma (HSTCL), and 1 subcutaneous panniculitis-like T-cell lymphoma (SPTCL). Using a cut-off value of > 25% of EBER-positive neoplastic lymphoid cells, EBV was positive in 22.6% of all cases. According to subtype, the neoplastic cells of 31.3% of PTCL, NOS and 100% of extranodal NKTCL, nasal type were EBER positive, whereas some cases of ALCL, AITCL, and ETTCL presented EBER-positive non-neoplastic cells, and all cells of HSTCL and SPTCL were EBV negative. Extranodal NKTCL, nasal type, presented the strongest association with EBV, followed by PTCL, NOS.

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Section: Ptcl Nos -Peripheral T-cell Lymphoma Not Otherwise Specificontrasting

confidence: 65%

Section: Ptcl Nos -Peripheral T-cell Lymphoma Not Otherwise Specifimentioning

confidence: 50%

Original paper Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization

Karaarslan¹,

Hekımgıl²,

Soydan³

et al. 2015

pjp

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“…The authors concluded that previous reports of EBV in Western patients with ALCL were probably a result of the inclusion of tumors no longer considered to be ALCL, such as CD30+ anaplastic tumors of B-cell origin. EBV, however, may be important in the pathogenesis of ALCL occurring in Asia and in immune-compromised hosts [12][13]. ALCL can occasionally mimic Hodgkin lymphoma (HL) because ALCL often presents in young patients and can have ReedSternberg-like cells, prominent sclerosis, and expression of CD30.…”

Section: Discussionmentioning

confidence: 99%

Primary Anaplastic Large Cell Lymphoma of the Nasal Cavity: A Case Report

Ouafki¹,

Sghiri²,

Boutayeb³

et al. 2013

IJCM

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Introduction: Anaplastic large-cell lymphoma occurring in the nasal cavity is a rare disease. The latest World Health Organization (WHO) Classification recognizes three distinct subtypes: primary systemic anaplastic lymphoma kinase positive been our case, primary systemic anaplastic lymphoma kinase negative and primary cutaneous types. Through this case study, we focus on the clinical presentation, treatment and prognostic characteristics of this pathology. Case Presentation: We report the case of a patient aged 32 years, who presented for seven months a runny nose associated with swelling of the face on the left side, without peripheral lymphadenopathy or general signs. A Blondeau scanner objectified a total filling of the frontal and left maxillary sinus, and a filling of the left nasal cavity. Complete resection of the tumor was performed. Histological examination was in favor of anaplastic large T-cell lymphoma anaplastic lymphoma kinase positive. The patient was stage IE according to Ann Arbor classification, with an International Prognostic Index estimated at one. Thus, the patient received six cycles of CHOP chemotherapy. Currently, he is in good loco-regional control with a decline of three months. Conclusion: The rarity of this case lies partly in the lymphomatous localization in the nasal cavity, and secondly in the anaplastic histology. It poses a diagnostic problem. So, we conclude that in case of any symptom of nasal cavities, it is necessary to explore and possibly biopsy if tumor, before surgery, because lymphomas are chemosensitive disease.

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“…In a recent study by us (Syed et al, 2011) ALCL was turned out to be the most common T-NHL in the archives of the largest referral centre of Pakistan. This variant of T-NHL however has the weakest association with EBV (Noorali et al 2004).…”

Section: Ebv and Anaplastic Large Cell Lymphoma (Alcl)mentioning

confidence: 92%

“…(Figure 8) So all in all strongest correlation of EBV was seen in this type of T-NHL. (Noorali et al, 2005). …”

Section: Ebv and Angioimmunoblastic T-cell Lymphoma (Ailt)mentioning

confidence: 99%

Infectious Aetiology of Cancer: Developing World Perspective

Pervez¹

2011

Modern Approaches to Quality Control

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Prevalence and characterization of anaplastic large cell lymphoma and its association with Epstein-Barr virus in Pakistani patients

Cited by 14 publications

References 39 publications

Original paper Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization

Original paper Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization

Primary Anaplastic Large Cell Lymphoma of the Nasal Cavity: A Case Report

Infectious Aetiology of Cancer: Developing World Perspective

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