Prevalence and characteristics of multidrug-resistant Proteus mirabilis from broiler farms in Shandong Province, China

Prevalence and antimicrobial susceptibility profiles of ESBL-producing Klebsiella Pneumoniae from broiler chicken farms in Shandong Province, China

“…The increasing resistance of bacteria to broad-spectrum β-lactam and peptide drugs has attracted public attention ( Xiang et al, 2018 ; Song et al., 2020 ; Liu et al., 2021 ; Wang et al., 2021 ; Li et al., 2022 ). β-lactam drugs are the most commonly used drugs in clinical treatment of bacterial infections caused by Enterobacteriaceae, meaning that disease treatment has accelerated the process of bacterial resistance ( Rubin and Pitout, 2014 ; Lee et al, 2021 ).…”

“…Environmental sources, food animals, and other factors have accelerated the spread of extended-spectrum β-lactamases ( ESBL ) in communities around the world ( Chong et al, 2018 )—especially the spread of carbapenem-resistant Enterobacteriaceae ( CRE ), which pose a major threat to global public health ( Chen et al, 2014 ; Li et al., 2022 ). The first human-derived carbapenem-resistant gene bla KPC isolate of K. pneumoniae recorded in China was discovered in Zhejiang Province in 2004 ( Wei et al, 2007 ).…”

Research Note: Molecular characterization of antimicrobial resistance and virulence gene analysis of Enterococcus faecalis in poultry in Tai'an, China

“…There, large-scale broiler breeding has involved high breeding density and, as a consequence, a variety of viral and bacterial diseases. Because the prevention and control of bacterial diseases has long relied on antibiotics, the extensive, long-term use of various antibiotics, especially for overdose, has increased drug-resistant bacteria and plagued China with some of the world's most intense bacterial resistance in livestock and poultry ( Li et al., 2022 , Song et al., 2020 , Wang et al., 2021 ). In turn, the ineffectiveness of antibiotics has increased the difficulty of preventing and controlling bacterial disease, raised the rate of frail chicks and mortality, and decreased both the feed conversion rate and production incomes.…”

Genomic Investigation of Proteus mirabilis Isolates Recovered From Pig Farms in Zhejiang Province, China

“…The strains isolated from Jinhua, Hangzhou, and Quzhou were designated PM 1 ( n = 101), PM 2 ( n = 240), and PM 3 ( n = 200), respectively ( Table 1 ). In brief, swabs were placed in sterile centrifuge tubes containing 3 ml Selenite Cystine Broth (SC; Hopebiol, Qingdao, China) and incubated at 37°C for 12 h. Loopfuls were then streaked on Salmonella-Shigella agar plates (SS; Becton Dickinson, Franklin Lakes, NJ, United States) and incubated as per above ( Li et al, 2022 ). Suspected P. mirabilis colonies were streak-purified a second time.…”

“…Importantly, molecular typing studies have identified animal strains that were transmitted to humans ( Reich et al, 2013 ; Olonitola et al, 2015 ; Lei et al, 2016 ). Previously reported 7.07% P. mirabilis from broiler chicken samples ( Li et al, 2022 ) and pig operations in China are currently experiencing large outbreaks of diarrheal disease in piglets ( Li, 2021 ). As a pathogen that can cause diarrhea, P. mirabilis has not attracted enough attention.…”