Prevalence and Association of Elevated Liver Transaminases in Type 2 Diabetes Mellitus Patients in Jeddah, Saudi Arabia

Alzahrani, Sami H.; Baig, Mukhtiar; Bashawri, Jamil; Aashi, Mooataz Mohammed; Shaibi, Faisal K; Alqarni, Dalya Abdulrahman

doi:10.7759/cureus.5166

Cited by 10 publications

(14 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is partly in agreement with the findings of (28) which reported significantly higher mean age in diabetic males than in female; significantly higher BMI in females than in male diabetic participants (28). They further recorded significantly higher mean fasting blood glucose level in female diabetic participants than in their male counterpart; a report which is in contrast to the finding in this study (28). There were stronger positive correlation between Weight Vs BMI (r=0.834; p=0.000), followed by Lipase Vs Amylase (r=0.767; p=0.000), least between Age Vs BMI (r=0.353; p=0.022) but weaker negative associations exist between Height Vs BMI (r=-0.490; p=0.001) and Weight Vs FBS (r=-0.325; p=0.036) in the diabetic subjects.…”

Section: Discussioncontrasting

confidence: 99%

Activities of Pancreatic Enzymes and Anthropometric Indices in Type 2 Diabetic Patients Attending Nnamdi Azikiwe University Teaching Hospital Nnewi, South Eastern, Nigeria

Ezeugwunne¹

2021

ijcsrr

View full text Add to dashboard Cite

Type 2 diabetes mellitus is the most common type of diabetes, having high blood glucose, reduced insulin secretion and / or inadequate glucagon secretion. The study is to assess the activities of pancreatic enzymes and anthropometric indices. 81 participants comprised 38 diabetic and 43 control were randomly recruited. Informed, oral and written consent was obtained from the participants. Ethical approval was obtained.6mls of fasting blood samples were collected. Plasma glucose; amylase and lipase activities were analyzed using standard laboratory methods. Body mass index (BMI) of participant was determined from height and weight. The results showed significantly increased plasma glucose level in the diabetic participants than in control at p=0.000 and in male diabetics than in female diabetics at p=0.048 in each case. But the activities of lipase, amylase, the mean age and BMI level were the same in both diabetic and control groups at p>0.05 respectively. BMI level, lipase and amylase activities were the same in both genders (p>0.05). Stronger positive correlation exist between Weight Vs BMI (r=0.834; p=0.000), followed by Lipase Vs Amylase (r=0.767; p=0.000), least between Age Vs BMI (r=0.353; p=0.022) but weaker negative associations exist between Height Vs BMI (r=-0.490; p=0.001) and Weight Vs FBS (r=-0.325; p=0.036) in the diabetic subjects. The significant higher level of blood glucose; stronger positive correlation between Lipase and Amylase; Weight and BMI may likely revealed pancreatic exocrine function abnormality in diabetes mellitus type 2.

show abstract

Section: Discussioncontrasting

confidence: 99%

Activities of Pancreatic Enzymes and Anthropometric Indices in Type 2 Diabetic Patients Attending Nnamdi Azikiwe University Teaching Hospital Nnewi, South Eastern, Nigeria

Ezeugwunne¹

2021

ijcsrr

View full text Add to dashboard Cite

show abstract

“…The pathophysiological mechanism responsible for these elevations in transaminases activities may indicate inflammation status that systemically impairs insulin signaling in the liver. It was reported that insulin resistance is caused by ALT regardless of age, body mass index, or gender [14]. A direct linkage was reported between transaminase enzymes elevation and hepatocyte injury.…”

Section: Serum Levels Of Liver Function Markersmentioning

confidence: 98%

Indications of Liver and Kidney Functions in Non-Insulin Dependent Diabetic Patients

Balaky

Kakey

2021

eijs

View full text Add to dashboard Cite

This study aimed at the investigation of abnormal liver and renal functions by biochemical manifestations of underlying metabolic abnormalities in relation to hyperglycemia in non-insulin-dependent diabetic patients. The study comprised 118 diabetic patients (56 males, 62 females) and 60 age-matched healthy non-diabetic controls (30 males, 30 females). All subjects were tested for serum levels of liver enzymatic indicators, which include aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), as well as non enzymatic parameters, including total bilirubin and total proteins.Also, serum levels of renal function markers, including microalbumin, creatinine, urea, and uric acid were measured. The findings of this study stated that serum ALT, AST, and ALP levels were significantly higher in diabetic males and females with both age ranges (40-59 & 60-80 years). Serum total bilirubin level showed a significant decrease in diabetic males and females of both age groups. However, total proteins level showed a significant increase in diabetic males and females of both age groups. The results also showed that the level of microalbumin in urine as well as those of creatinine, urea, and uric acid in the serum were significantly higher in diabetic males and females. The present study concludes that there is a bidirectional relationship of enzymatic and non enzymatic liver and renal functions markers with the hyperglycemic status in Type 2 diabetes mellitus.

show abstract

“…Hasil analisis hubungan yang dilakukan antara kadar ALT dengan kadar kolesterol total, kadar kolesterol HDL, kadar kolesterol LDL, dan kadar trigliserida menggunakan uji korelasi Spearman rank, menunjukkan bahwa tidak terdapat hubungan bermakna dan nilai korelasi yang menunjukkan hubungan yang negatif. Hasil penelitian ini sejalan dengan penelitian yang dilakukan di Arab Saudi oleh Alzahrani et al 12 yang menyatakan bahwa tidak terdapat hubungan bermakna antara peningkatan kadar ALT dengan kadar kolesterol total, HDL, LDL, dan trigliserida. Berbeda halnya dengan penelitian yang dilakukan oleh Al-Jameil et al 13 yang menunjukkan adanya hubungan positif yang bermakna antara peningkatan kadar ALT dengan kadar kolesterol total, LDL, dan trigliserida.…”

Section: Bahasanunclassified

“…Hal ini sejalan dengan penelitian Saligram et al 15 terhadap pasien DM tipe 2 yang baru terdiagnosis yang menunjukkan bahwa tidak terdapat hubungan bermakna antara kadar ALT dengan kadar HbA1C. Hasil penelitian ini juga sejalan dengan penelitian oleh Alzahrani et al 12 yang menyatakan bahwa tidak terdapat hubungan antara peningkatan kadar ALT dengan kadar HbA1c, namun hasil penelitian ini bertolak belakang dengan penelitian yang dilakukan oleh Shahwan et al 14 yang menyimpulkan adanya hubungan antara peningkatan kadar ALT pada pasien dengan kadar HbA1c ≥7%.…”

Section: Bahasanunclassified

Hubungan Profil Lipid dan HbA1C dengan Kadar Alanin Aminotransferase pada Pasien Diabetes Melitus Tipe 2

Patulak¹,

Pandelaki²,

Waleleng³

2019

eCL

View full text Add to dashboard Cite

Elevated HbA1C in patients with T2DM will increases the risk of complications. Dyslipidemia is a common comorbidity in patients with T2DM. Uncontrolled T2DM patients and dyslipidemia have a high risk of chronic complications such as non alcoholic fatty liver disease (NAFLD) that causes liver cell damage. Alanine aminotransferase (ALT) test is typically used to detect liver cell damage. This study was aimed to obtain the relationship between lipid profile and HbA1c and ALT among T2DM patients at Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive and analytical study with a cross sectional design using secondary data of T2DM patients at the Endocrine Polyclinic of Prof. R. D. Kandou Hospital Manado from January to September 2019. The results of the Spearman rank correlation test were, as follows: correlation between ALT and total cholesterol levels with p=0.625 and r=-0.080; correlation between ALT and HDL levels with p =0.302 and r=-0.167; correlation between ALT and LDL levels with p=0.625 and r=-0.080; correlation between ALT and triglyceride levels with p=0.964 and r=-0.007; and correlation between ALT and HbA1c levels with p=0.237 and r=-0.191. In conclusion, there were no significant relationships between lipid profile and HbA1c levels and ALT.Keywords: T2DM, HbA1c, ALT, lipid profile Abstrak: Peningkatan HbA1c pada pasien diabetes melitus tipe 2 (DMT2) akan mening-katkan terjadinya risiko komplikasi. Dislipidemia merupakan komorbid yang umum ditemukan pada pasien DMT2. Penderita DMT2 yang tidak terkontrol disertai dislipidemia memiliki risiko tinggi untuk mendapatkan komplikasi kronik seperti non alcoholic fatty liver disease (NAFLD) yang mengakibatkan kerusakan sel hati. Pemeriksaan laboratorium yang sering dilakukan untuk melihat adanya kerusakan pada sel hati yaitu alanin aminotransferase (ALT). Penelitian ini bertujuan untuk mengetahui hubungan antara profil lipid dan HbA1c dengan kadar ALT pada pasien DMT2 di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang menggunakan data sekunder pasien DMT2 yang datang berobat ke Poliklinik Endokrin RSUP Prof. Dr. R. D. Kandou pada bulan Januari-September 2019. Hasil uji korelasi Spearman rank menunjukkan nilai hubungan antara ALT dan kolesterol total kadar p=0,625 dan r=-0,080; nilai hubungan antara ALT dan kadar HDL p=0,302 dan r=-0,167; nilai hubungan antara ALT dan kadar LDL p=0,625 dan r=-0,080; nilai hubungan antara ALT dan kadar trigliserida p=0,964 dan r=-0,007; serta nilai hubungan antara ALT dan kadar HbA1C p=0,237 dan r=-0,191. Simpulan penelitian ini ialah tidak terdapat hubungan antara profil lipid dan HbA1c dengan kadar ALT.Kata kunci: diabetes melitus tipe 2, HbA1c, ALT, profil lipid

show abstract

Prevalence and Association of Elevated Liver Transaminases in Type 2 Diabetes Mellitus Patients in Jeddah, Saudi Arabia

Cited by 10 publications

References 23 publications

Activities of Pancreatic Enzymes and Anthropometric Indices in Type 2 Diabetic Patients Attending Nnamdi Azikiwe University Teaching Hospital Nnewi, South Eastern, Nigeria

Activities of Pancreatic Enzymes and Anthropometric Indices in Type 2 Diabetic Patients Attending Nnamdi Azikiwe University Teaching Hospital Nnewi, South Eastern, Nigeria

Indications of Liver and Kidney Functions in Non-Insulin Dependent Diabetic Patients

Hubungan Profil Lipid dan HbA1C dengan Kadar Alanin Aminotransferase pada Pasien Diabetes Melitus Tipe 2

Contact Info

Product

Resources

About