Presynaptic modulation of synaptic transmission in Helix pomatia: The effects of serotonin and dopamine antagonists

Juel, Carsten

doi:10.1016/0028-3908(81)90003-4

Neuropharmacology

1981

DOI: 10.1016/0028-3908(81)90003-4

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Presynaptic modulation of synaptic transmission in Helix pomatia: The effects of serotonin and dopamine antagonists

Carsten Juel

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1982

1996

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Cited by 9 publications

References 18 publications

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Tyrosine hydroxylase-negative, dopaminergic neurons are targets for transmitter-depleting action of haloperidol in the snail brain

et al. 1996

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1. The effects of long term administration of micromolar concentrations of the D2 antagonist haloperidol upon monoaminergic neurons in the snail Lymnaea stagnalis was investigated. 2. Treatment by bath application with 0.5-2.0 micromolar haloperidol, caused a significant, continuous depletion of dopamine levels in the nervous system as revealed by high performance liquid chromatography. 3. A transient depletion of serotonin was also observed, but DOPA and norepinephrine levels were unaffected. Similar depletion of dopamine was observed after the land snail, Achatina fulica, was injected with haloperidol on each of 4 consecutive days. 4. The depletion of dopamine as revealed with glyoxylate-induced fluorescence in Lymnaea appears to be restricted to a subpopulation of catecholaminergic neurons which are immuno-negative for tyrosine hydroxylase, the synthetic enzyme responsible for the conversion of tyrosine to DOPA. 5. The results thus demonstrate a depleting action of low micromolar doses of chronic haloperidol on specific subsets of dopaminergic neurons and a novel preparation for studying catecholaminergic mechanisms operating across the animal kingdom.

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Tyrosine hydroxylase-negative, dopaminergic neurons are targets for transmitter-depleting action of haloperidol in the snail brain

et al. 1996

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Enkephalin increases the efficacy of dopaminergic transmission in Helix pomatia

Juel

1982

Neuropharmacology

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The pharmacology of molluscan neurons

S.-Rózsa

1984

Progress in Neurobiology

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Presynaptic modulation of synaptic transmission in Helix pomatia: The effects of serotonin and dopamine antagonists

Cited by 9 publications

References 18 publications

Tyrosine hydroxylase-negative, dopaminergic neurons are targets for transmitter-depleting action of haloperidol in the snail brain

Tyrosine hydroxylase-negative, dopaminergic neurons are targets for transmitter-depleting action of haloperidol in the snail brain

Enkephalin increases the efficacy of dopaminergic transmission in Helix pomatia

The pharmacology of molluscan neurons

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