Enkephalin increases the efficacy of dopaminergic transmission in Helix pomatia

Juel, Carsten

doi:10.1016/0028-3908(82)90137-x

Cited by 13 publications

(2 citation statements)

References 14 publications

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“…' Little is known about the function of vertebrate peptides in invertebrates . However, in molluscs and planarians a relationship between enkephalins and the dopaminergic system has been demonstrated (Stefano -et al, 1981 ;Juel, 1982 ;Venturini et al, 1983) . Interestingly, the cestodes gave a positive reaction with the anti-enkephalins but lack dopamine, while M, lineare contains catecholamines but gave a negative result for the enkephalins .…”

Section: Discussionmentioning

confidence: 99%

Neuropeptides in free-living and parasitic flatworms (Platyhelminthes). An immunocytochemical study

1986

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The nervous systems of the turbellarians Microstomum lineare and Polycelis nigra and of the cestodes Diphyllobothrium dendriticum and Schistocephalus solidus were studied by means of the peroxidaseantiperoxidase (PAP) immunocytochemical method, with the use of antisera to the neuropeptides FMRFamide, vasotocin, leu-enkephalin, met-enkephalin, neurotensin, somatostatin, and VIP, and to the bioamine serotonin. Anti-FMRF-amide positive perikarya and fibers occurred in all species, while the occurrence of the vertebrate brain-gut peptides and serotonin varied between the species . Anti-somatostatin and anti-VIP gave a negative result . Anti-FMRF-amide and anti-vasotocin positive immunoreactivity was found in the brain and gut of M. lineare, and in the CNS and the peripheral nerve net of the cestodes . We suggest that the brain-gut peptides of free-living flatworms act on the subtegumental region in the cestodes, which lack a gut but absorb their nutrients directly through the tegument .

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Section: Discussionmentioning

confidence: 99%

Neuropeptides in free-living and parasitic flatworms (Platyhelminthes). An immunocytochemical study

1986

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“…Opioid receptors have been localized on dopamine terminals in a number of mammalian preparations. Work with molluscs also suggests a complex interaction of opioids with dopamine (Bezrukova & Solntseva, 1981; Juel, 1982; Solntseva, Bezrukova, & Amosova, 1983; Stefano, 1982). Because dopamine is known to stimulate FMP in Limax (Wieland & Gelperin, 1983), our results suggest that U50,488H might enhance the FMP response to dopamine just as it enhanced lip-stimulated FMP.…”

Section: Discussionmentioning

confidence: 99%

Opiate agonists activate feeding in Limax: Comparison of in vivo and in vitro effects.

Wong¹,

Delaney²,

Gelperin³

1991

Behavioral Neuroscience

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The neural control system for feeding in the terrestrial mollusc Limax maximus is modulated by at least two major families of peptides. Sequence homology between one of the peptides known to modulate Limax feeding and some members of the opioid peptide family suggested that opioid peptides might also modulate Limax feeding. Experiments with the mu agonist morphine and the kappa agonist U50,488H showed that the probability of feeding, but not meal size, was increased by morphine injection into intact animals, whereas the length of feeding motor program responses elicited from the isolated lip-brain preparation of Limax was augmented by U50,488H. The behavioral effect of morphine was blocked by naltrexone injection, whereas the physiological effect of U50,488H was blocked by naloxone. Factors that influence the behavioral and electrophysiological effects of opioids on mollusc feeding are discussed.

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Immunocytochemical demonstration of neuropeptides and serotonin in the tapeworm Diphyllobothrium dendriticum

Gustafsson¹,

Wikgren²,

Karhi³

et al. 1985

Cell Tissue Res.

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The present immunocytochemical study concerns the distribution of four neuropeptides, FMRF-amide, vasotocin, leu-enkephalin and neurotensin, and of the bioamine serotonin in the plerocercoid larva of Diphyllobothrium dendriticum. Anti-FMRF-amide and vasotocin-reactivity occurs in perikarya and nerve fibres in the CNS and PNS of this worm. The peptide-containing fibres surround and seem to innervate the musculature and to terminate beneath the basal lamina of the tegument at the inner surface of the bothridia, suggesting a neurotransmitter function. Anti-leu-enkephalin reaction occurs in perikarya and fibres in the main nerve cords and in the PNS. Anti-neurotensin reactive fibres were observed in the neuropile of the nerve cords. Serotonin immunoreactivity was found in neurons in the ganglionic commissure of the brain and along the main nerve cords. This study is the first immunocytochemical identification of neuropeptides and serotonin in a parasitic flatworm and the information gained may be of importance for the development of new antihelminthics.

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Enkephalin increases the efficacy of dopaminergic transmission in Helix pomatia

Cited by 13 publications

References 14 publications

Neuropeptides in free-living and parasitic flatworms (Platyhelminthes). An immunocytochemical study

Neuropeptides in free-living and parasitic flatworms (Platyhelminthes). An immunocytochemical study

Opiate agonists activate feeding in Limax: Comparison of in vivo and in vitro effects.

Immunocytochemical demonstration of neuropeptides and serotonin in the tapeworm Diphyllobothrium dendriticum

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