Presumptive pure erythroid leukemia in a dog

Mylonakis, Mathios E.; Kritsepi‐Konstantinou, Maria; Vernau, William; Valli, V. E.; Pardali, Dimitra; Koutinas, A. F.

doi:10.1177/1040638712452731

Cited by 7 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CD34 is exclusively expressed by early precursors, thereby being regarded as a marker of AL and associated with a short survival in dogs with neoplastic lymphocytosis . However, CD34 expression has been described in a subset of canine lymphoma, and CD34‐negative ALs have also been reported . Therefore, the expression of CD34 by itself should not be used to confirm or exclude a diagnosis of AL.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in canine acute leukaemias: a retrospective study

Novacco

Comazzi

Marconato

et al. 2015

Vet Comparative Oncology

View full text Add to dashboard Cite

Canine acute leukaemias (ALs) have a poor prognosis, with reported survival times (ST) of only a few weeks or months. Also, clinical studies assessing prognostic factors are lacking. This study aims to retrospectively assess variables that predict ST in dogs with AL, and to identify correlations between outcome and therapeutic protocols. Diagnosis and sub-classification into AL subtypes was made based on haematological findings, morphological assessment and flow cytometric immunophenotyping. Clinical-pathological features of AL subtypes at presentation concurred with those described in the literature. A normal neutrophil count at presentation significantly prolonged ST (P = 0.027). Additionally, there was a trend for anaemic dogs to have shorter survival compared with those without anaemia, and the incorporation of cytosine in the chemotherapy protocol produced a moderate but not significant increase in median ST for dogs with AL. Further prospective studies with standardized treatments are needed to confirm and improve our results.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic factors in canine acute leukaemias: a retrospective study

Novacco

Comazzi

Marconato

et al. 2015

Vet Comparative Oncology

View full text Add to dashboard Cite

show abstract

“…More than 50% of the total nucleated cells in the bone marrow are erythroids and at least 30% are myeloblast precursors [ 3 ]. Erythroid leukemia or AML-M6B represents a rare form of leukemia in horses and is occasionally reported in dogs [ 30 ]. Forbes et al [ 31 ] identified an AML-M6B in a 10-week-old foal, referred for long-duration anemia.…”

Section: Reviewmentioning

confidence: 99%

A review of current knowledge of myeloproliferative disorders in the horse

2021

View full text Add to dashboard Cite

Myeloid disorders are conditions being characterized by abnormal proliferation and development of myeloid lineage including granulocytes (neutrophils, eosinophils and basophils), monocytes, erythroids, and megakaryocytes precursor cells. Myeloid leukemia, based on clinical presentation and proliferative rate of neoplastic cells, is divided into acute (AML) and myeloproliferative neoplasms (MPN). The most commonly myeloid leukemia reported in horses are AML-M4 (myelomonocytic) and AML-M5 (monocytic). Isolated cases of AML-M6B (acute erythroid leukemia), and chronic granulocytic leukemia have also been reported. Additionally, bone marrow disorders with dysplastic alterations and ineffective hematopoiesis affecting single or multiple cell lineages or myelodysplastic diseases (MDS), have also been reported in horses. MDSs have increased myeloblasts numbers in blood or bone marrow, although less than 20%, which is the minimum level required for diagnosis of AML. This review performed a detailed description of the current state of knowlegde of the myeloproliferative disorders in horses following the criteria established by the World Health Organization.

show abstract

“…Praktycznie we wszystkich przypadkach szpik kostny był bogatokomórkowy i zawierał absolutną dominację komórek nowotworowych, dzięki czemu rozpoznanie było stosunkowo proste. Chociaż wiarygodne rozpoznanie ostrej białaczki można postawić na podstawie stwierdzenia, że minimum 20-30% komórek szpiku to komórki blastyczne, to w zdecydowanej większości opisywanych przypadków liczba blastów jest zdecydowanie wyższa i często osiąga od 70% do 90% wszystkich komórek jądrzastych szpiku kostnego (10,14,15,21). W prezentowanych badaniach podczas oceny cytologicznej szpiku kostnego prawidłowe komórki hematopoezy były obserwowane rzadko, niekiedy nie były one nieobecne, co uznaje się z typową cechę ostrych białaczek u psów (10).…”

Section: Wyniki I Omówienieunclassified

“…Spośród pozostałych 24 psów, 22 (83%) psy poddano eutanazji tuż po uzyskaniu rozpoznania lub wkrótce po nim, z kolei 2 (17%) psy padły spontanicznie w czasie niedługim od uzyskania rozpoznania (u jednego psa odnotowano silny napad padaczki, u innego doszło do ciężkiej niewydolności oddechowej). Jak podają inni autorzy (4,11,15,21,23), rokowanie u psów z rozpoznaną ostrą białaczką jest złe, zdecydowana większość chorych zwierząt pada spontanicznie lub jest poddawana eutanazji w związku z szybko pogarszającym się stanem zdrowia i niekorzystnym rokowaniem. W badaniach Novacco i wsp.…”

unclassified

Acute leukemias in dogs: Analysis of 31 cases.

Sapierzyński¹,

Hutsch²,

Czopowicz³

et al. 2017

Medycyna Weterynaryjna

View full text Add to dashboard Cite

SummaryThe aim of the present study was to analyse epidemiological, cytological, laboratory and clinical data from canine acute leukemia (AL) cases. The study was conducted from 2009 to 2015, and included 2384 dogs undergoing cytological examination in two veterinary practices in Warsaw. The analysis included dogs in which bone marrow cytology revealed acute leukemia, regardless of its subtype. Data on breed, age, sex, as well as clinical signs and results of haematological examination were collected for every dog. Breed predisposition to acute leukemia was calculated by statistical methods on the basis of the theoretical distribution of canine breeds in Poland. Acute leukemia was diagnosed in 31 dogs (24.7%) undergoing bone marrow cytology, that is, in 1.3% of all the dogs examined by cytology during the study period. The disease was diagnosed mainly in adults, and a strong predisposition was found particularly in German shepherds and Golden retrievers. The median duration of clinical signs from the onset to diagnosis was 14 days. The clinical signs were mostly non-specific (apathy, recurrent fever, lack of appetite), whereas lymphadenomegaly or/and splenomegaly were observed more seldom. Hematology revealed neoplastic leukocytosis in 75% of dogs, whereas anemia and trombocytopenia were observed in 86% and 85% of patients, respectively. Regardless of the leukemia subtype, prognosis was poor. In conclusion, it can be stated that according to current knowledge on canine acute leukemias, bone marrow cytology based on routine staining methods is sufficient for correct diagnosis in a vast majority of cases.

show abstract

Presumptive pure erythroid leukemia in a dog

Cited by 7 publications

References 12 publications

Prognostic factors in canine acute leukaemias: a retrospective study

Prognostic factors in canine acute leukaemias: a retrospective study

A review of current knowledge of myeloproliferative disorders in the horse

Acute leukemias in dogs: Analysis of 31 cases.

Contact Info

Product

Resources

About