2020
DOI: 10.1016/j.jmbbm.2020.103771
|View full text |Cite
|
Sign up to set email alerts
|

Pressure-induced collagen degradation in arterial tissue as a potential mechanism for degenerative arterial disease progression

Abstract: Pressure-induced collagen degradation in arterial tissue as a potential mechanism for degenerative arterial disease progression.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
3
0

Year Published

2020
2020
2022
2022

Publication Types

Select...
3
2
1
1

Relationship

1
6

Authors

Journals

citations
Cited by 8 publications
(3 citation statements)
references
References 48 publications
(96 reference statements)
0
3
0
Order By: Relevance
“…Whilst ultrasound studies have suggested that characterizing strains across a plaque can differentiate between stable and vulnerable cases [26,27], these imaging studies do not provide any insights into the underlying characteristics of the structure which determines the tissue's mechanical behaviour. In a recent ex-vivo investigation on porcine carotid arteries, Gaul et al, [2020] showed that collagen degradation in arterial tissue is a strain dependent process, with increased intraluminal pressure leading to higher circumferential strain and higher collagen degradation [28]. That study also showed premature failure of arteries following accelerated collagen degradation due to the significant load bearing role of collagen in the dominant loading direction.…”
Section: Introductionmentioning
confidence: 99%
“…Whilst ultrasound studies have suggested that characterizing strains across a plaque can differentiate between stable and vulnerable cases [26,27], these imaging studies do not provide any insights into the underlying characteristics of the structure which determines the tissue's mechanical behaviour. In a recent ex-vivo investigation on porcine carotid arteries, Gaul et al, [2020] showed that collagen degradation in arterial tissue is a strain dependent process, with increased intraluminal pressure leading to higher circumferential strain and higher collagen degradation [28]. That study also showed premature failure of arteries following accelerated collagen degradation due to the significant load bearing role of collagen in the dominant loading direction.…”
Section: Introductionmentioning
confidence: 99%
“…Collagen fibres are the main load bearing constituent in arterial tissue and many other soft biological tissues (deBotton and Hariton, 2006;Baaijens et al, 2010). The important role of collagen fibres in bearing physiological loads is emphasised in studies such as Sommer et al (2010) and Gaul et al (2020). The specific role of collagen fibres in arteries under supraphysiological loads is discussed in studies such as Weisbecker et al (2013), Schriefl et al (2015), and Ghasemi et al (2018).…”
Section: Introductionmentioning
confidence: 99%
“…Collagen fibres are the main load bearing constituent in arterial tissue and many other soft biological tissues (deBotton and Hariton, 2006;Baaijens et al, 2010). The important role of collagen fibres in bearing physiological loads is emphasised in studies such as Sommer et al (2010) and Gaul et al (2020). The specific role of collagen fibres in arteries under supraphysiological loads is discussed in studies such as Weisbecker et al (2013), Schriefl et al (2015), and Ghasemi et al (2018).…”
Section: Introductionmentioning
confidence: 99%