2021
DOI: 10.3389/fphys.2021.718470
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Development of a Collagen Fibre Remodelling Rupture Risk Metric for Potentially Vulnerable Carotid Artery Atherosclerotic Plaques

Abstract: Atherosclerotic plaque rupture in carotid arteries can lead to stroke which is one of the leading causes of death or disability worldwide. The accumulation of atherosclerotic plaque in an artery changes the mechanical properties of the vessel. Whilst healthy arteries can continuously adapt to mechanical loads by remodelling their internal structure, particularly the load-bearing collagen fibres, diseased vessels may have limited remodelling capabilities. In this study, a local stress modulated remodelling algo… Show more

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Cited by 3 publications
(5 citation statements)
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References 60 publications
(122 reference statements)
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“…It is expected that if higher levels of axial strain are imposed, the angle of fibers would alter and would start to play a more significant role in the stress distribution and peak stress values. 14 To conclude, this study has shown the importance of including these methods in determining a more accurate stress distribution throughout the vessel wall. Consequently, for stress to be used clinically as a rupture vulnerability measure, these methods must be used to provide a better estimate of the stress being experienced in‐vivo.…”
Section: Discussionmentioning
confidence: 70%
See 3 more Smart Citations
“…It is expected that if higher levels of axial strain are imposed, the angle of fibers would alter and would start to play a more significant role in the stress distribution and peak stress values. 14 To conclude, this study has shown the importance of including these methods in determining a more accurate stress distribution throughout the vessel wall. Consequently, for stress to be used clinically as a rupture vulnerability measure, these methods must be used to provide a better estimate of the stress being experienced in‐vivo.…”
Section: Discussionmentioning
confidence: 70%
“…This could be from the fact that different ranges of axial strain were not implemented in our material parameter estimation and kept constant for all models. It is expected that if higher levels of axial strain are imposed, the angle of fibers would alter and would start to play a more significant role in the stress distribution and peak stress values 14 . To conclude, this study has shown the importance of including these methods in determining a more accurate stress distribution throughout the vessel wall.…”
Section: Discussionmentioning
confidence: 72%
See 2 more Smart Citations
“…Other reorientation algorithms have successfully predicted the fiber distribution in various tissues such as mitral valves [2,4], carotid arteries [9,31], articular cartilage [5] and cornea [32]. The most significant difference between these kind of tissues is the mechanical surrounding environment which dictates the fiber distribution.…”
Section: Comparison With Other Methodsmentioning
confidence: 99%