Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing

Zhang, Xiaoyan; Kunz, Hawley; Gries, Kevin J.; Hart, Corey R.; Polley, Eric C.; Lanza, Ian R.

doi:10.1113/jp281691

Cited by 17 publications

(17 citation statements)

References 50 publications

(184 reference statements)

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“…There are progressive declines in peak VO 2 (ref. 73 ; and reviewed by Russ and Lanza, ref. 74 ) and strength ( 8 , 70 , 73 , 75 ) with age.…”

Section: Tissue-specific Changes In Structure and Function With Agingmentioning

confidence: 99%

“… 73 ; and reviewed by Russ and Lanza, ref. 74 ) and strength ( 8 , 70 , 73 , 75 ) with age. The loss of strength (2.5%–4% per year) is substantially greater than the loss of muscle (1% per year), implying that reduced muscle function plays an important role in the loss of strength ( 75 ) with age.…”

Section: Tissue-specific Changes In Structure and Function With Agingmentioning

confidence: 99%

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Metabolic changes in aging humans: current evidence and therapeutic strategies

Palmer¹,

Jensen²

2022

Journal of Clinical Investigation

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Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes. These age-related changes are further exacerbated by a sedentary lifestyle and can be in part prevented by maintenance of activity with aging. Here we explore the age-related changes seen in individual metabolic tissues — adipose, muscle, and liver — as well as globally in older adults. We also discuss the available evidence for therapeutic interventions such as caloric restriction, resistance training, and senolytic and senomorphic drugs to maintain healthy metabolism with aging, focusing on data from human studies.

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“…There are progressive declines in peak VO 2 (ref. 73 ; and reviewed by Russ and Lanza, ref. 74 ) and strength ( 8 , 70 , 73 , 75 ) with age.…”

Section: Tissue-specific Changes In Structure and Function With Agingmentioning

confidence: 99%

Section: Tissue-specific Changes In Structure and Function With Agingmentioning

confidence: 99%

Metabolic changes in aging humans: current evidence and therapeutic strategies

Palmer¹,

Jensen²

2022

Journal of Clinical Investigation

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“…Skeletal muscle oxidative capacity, also referred to as mitochondrial respiratory capacity, was assessed as previously described [ 33 , 34 , 35 , 36 ]. Approximately 50 mg of skeletal muscle tissue obtained from the biopsy sample was immediately placed in ice cold preservation buffer (7.23 mM K 2 EGTA, 2.77 mM CaK 2 EGTA, 20 mM imidazole, 0.5 mM DTT, 20 mM taurine, 5.7 mM ATP, 14.3 mM phosphocreatine, 6.56 mM MgCl 2 ·6H 2 O and 50 mM MES; (pH 7.1, 295 mosmol/kgH 2 O)).…”

Section: Methodsmentioning

confidence: 99%

Effects of Combined Inorganic Nitrate and Nitrite Supplementation on Cardiorespiratory Fitness and Skeletal Muscle Oxidative Capacity in Type 2 Diabetes: A Pilot Randomized Controlled Trial

et al. 2022

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Nitric oxide (NO) stimulates mitochondrial biogenesis in skeletal muscle. However, NO metabolism is disrupted in individuals with type 2 diabetes mellitus (T2DM) potentially contributing to their decreased cardiorespiratory fitness (i.e., VO2max) and skeletal muscle oxidative capacity. We used a randomized, double-blind, placebo-controlled, 8-week trial with beetroot juice containing nitrate (NO3−) and nitrite (NO2−) (250 mg and 20 mg/day) to test potential benefits on VO2max and skeletal muscle oxidative capacity in T2DM. T2DM (N = 36, Age = 59 ± 9 years; BMI = 31.9 ± 5.0 kg/m2) and age- and BMI-matched non-diabetic controls (N = 15, Age = 60 ± 9 years; BMI = 29.5 ± 4.6 kg/m2) were studied. Mitochondrial respiratory capacity was assessed in muscle biopsies from a subgroup of T2DM and controls (N = 19 and N = 10, respectively). At baseline, T2DM had higher plasma NO3− (100%; p < 0.001) and lower plasma NO2− levels (-46.8%; p < 0.0001) than controls. VO2max was lower in T2DM (−26.4%; p < 0.001), as was maximal carbohydrate- and fatty acid-supported oxygen consumption in permeabilized muscle fibers (−26.1% and -25.5%, respectively; p < 0.05). NO3−/NO2− supplementation increased VO2max (5.3%; p < 0.01). Further, circulating NO2−, but not NO3−, positively correlated with VO2max after supplementation (R2= 0.40; p < 0.05). Within the NO3−/NO2− group, 42% of subjects presented improvements in both carbohydrate- and fatty acid-supported oxygen consumption in skeletal muscle (vs. 0% in placebo; p < 0.05). VO2max improvements in these individuals tended to be larger than in the rest of the NO3−/NO2− group (1.21 ± 0.51 mL/(kg*min) vs. 0.31 ± 0.10 mL/(kg*min); p = 0.09). NO3−/NO2− supplementation increases VO2max in T2DM individuals and improvements in skeletal muscle oxidative capacity appear to occur in those with more pronounced increases in VO2max.

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“…Reconhecidamente, o envelhecimento está associado à diminuição da função de diversos órgãos e sistemas, que irão provocar efeitos negativos na saúde e na qualidade de vida dos indivíduos. Dentre elas, pode-se descrever alterações na composição corporal, como a diminuição da massa muscular -sarcopenia (TIELAND et al, 2018) e da massa ósseaosteoporose (ASPRAY; HILL, 2019), e o aumento da massa gorda (LIU et al, 2020), a diminuição da flexibilidade (BANGSBO et al, 2019) e a diminuição da capacidade cardiorrespiratória (ZHANG et al, 2021).…”

Section: Introductionunclassified