Metabolic changes in aging humans: current evidence and therapeutic strategies

Palmer, Allyson K.; Jensen, Michael D.

doi:10.1172/jci158451

Cited by 77 publications

(39 citation statements)

References 123 publications

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“…At 13 months of age, both groups presented an increase in triglycerides, glucose, and cholesterol, which could be due to the transition from young adulthood to middle age, generating an accumulation of excess visceral fat, muscle mass, and strength loss, and an increase in adipocyte size in subcutaneous fat leading to and Jensen, 2022. It is important to note that no significant differences were found when comparing the values of these parameters between the two groups at 6 and 13 months considering the Harlan manual (Giknis and Clifford, 2008).…”

Section: Discussionmentioning

confidence: 99%

Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats

Salas-Venegas

Santín-Márquez

Ramírez-Carreto

et al. 2023

Front. Aging Neurosci.

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Being overweight and obesity are world health problems, with a higher prevalence in women, defined as abnormal or excessive fat accumulation that increases the risk of chronic diseases. Excess energy leads to adipose expansion, generating hypertrophic adipocytes that produce various pro-inflammatory molecules. These molecules cause chronic low-intensity inflammation, affecting the organism’s functioning and the central nervous system (CNS), inducing neuroinflammation. The neuroinflammatory response during obesity occurs in different structures of the CNS involved in memory and learning, such as the cortex and the hippocampus. Here we analyzed how obesity-related peripheral inflammation can affect CNS physiology, generating neuroinflammation and promoting cellular senescence establishment. Since some studies have shown an increase in senescent cells during aging, obesity, and neurodegenerative diseases, we proposed that cellular senescence participation may contribute to the cognitive decline in an obesity model of middle-aged female Wistar rats. The inflammatory state of 6 and 13 months-old female Wistar rats fed with a hypercaloric diet was measured in serum and CNS (cortex and hippocampus). Memory was evaluated using the novel object recognition (NOR) test; the presence of senescent markers was also determined. Our data suggest that the systemic inflammation generated by obesity induces a neuroinflammatory state in regions involved in learning and memory, with an increase in senescent markers, thus proposing senescence as a potential participant in the negative consequences of obesity in cognition.

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Section: Discussionmentioning

confidence: 99%

Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats

Salas-Venegas

Santín-Márquez

Ramírez-Carreto

et al. 2023

Front. Aging Neurosci.

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“…Penuaan berhubungan dengan terjadinya SM (Palmer & Jensen, 2022). Gaya hidup sedentari mempercepat terjadinya SM karena terjadinya kelebihan kalori dan gangguan metabolisme lemak.…”

Section: Hasil Penelitian Dan Pembahasan a Hasilunclassified

“…Gaya hidup sedentari mempercepat terjadinya SM karena terjadinya kelebihan kalori dan gangguan metabolisme lemak. Sehingga restriksi kalori dan peningkatan aktivitas fisik dapat menurunkan resiko SM (Lin & Li, 2021;Palmer & Jensen, 2022;World Health Organization (WHO), 2022). Suatu studi meta-analisis yang dilakukan Myers et al (2019) menemukan bahwa pada penderita sindroma metabolic, gangguan metabolisme dapat dihambat atau bahkan dikurangi dengan olahraga aerobic atau resistensi dan kombinasi keduanya.…”

Section: Hasil Penelitian Dan Pembahasan a Hasilunclassified

Program Peningkatan Pengetahuan untuk Lansia dengan Sindroma Metabolik di Cimahi

Goenawan

Lesmana²,

Tarawan³

et al. 2023

Creat J. Cumn Enga

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ABSTRAK Sindroma metabolik (SM) merupakan masalah kesehatan yang meningkat di seluruh dunia. Di Indonesia, angka penderita sindroma metabolik mencapai 21,8%. Penderita SM meningkat pada lansia karena telah terjadi berbagai kelainan metabolisme. Sehingga diperlukan peningkatan kesadaran masyarakat mengenai komplikasi SM. Masyarakat juga diharapkan untuk mengendalikan faktor resiko SM seperti pengaturan pola aktivitas fisik. Aktifitas fisik seperti olahraga telah terbukti dapat menurunkan resistensi insulin dan memperbaiki profil lipid. Penyuluhan mengenai komplikasi SM dan pengendaliannya dengan cara meningkatkan aktivitas fisik diharapkan dapat memberikan edukasi pada masyarakat. Kegiatan yang dilakukan berupa wawancara mengenai pengetahuan masyarakat mengenai SM dan olahraga yang tepat dalam penanganan sindroma metabolik. Survey pada masyarakat menunjukkan sebagian besar masyarakat (72%) telah mengetahui sindroma metabolik, namun tidak mengetahui penyakit yang dapat disebabkan oleh SM (63%). Disamping itu, hanya 55% responden yang megetahui pengaruh olahraga dalam perbaikan SM. Kegiatan dilanjutkan dengan penyuluhan dan tanya jawab mengenai SM. Melalui kegiatan pengabdian pada masyarakat ini, diharapkan terjadi perubahan gaya hidup di masyarakat sehingga SM dapat diatasi. Kata Kunci: Lansia, Olahraga, Penyuluhan, Sindroma Metabolik ABSTRACT Metabolic syndrome (MS) prevalence is increasing worldwide. In Indonesia, MS prevalence was 21.8% in 2018. MS is a risk factor for cardiovascular disease and diabetes. MS risk factor is increased in the elderly. An increase in physical activity has been proven to reduce the MS risk factor. Thus, behavioral changes are the key factor to manage MS. In this community service, we gave education to the elderly population in the Cimahi area, Bandung, West Java about MS was done prior to the education. We found that most of the community members already know about MS. However, only 55% of respondents understand a complication of MS. To educate the local people about the MS prevention program, we gave seminars and counseling. Changes in behavior including diet programs and exercise are the key factor to prevent MS. Keywords: Elderly, Education, Metabolic Syndrome, Physical Exercise

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“…Through constitutive changes in mitochondrial oxidative phosphorylation (OXPHOS), age-related metabolic diseases lead to mitochondrial dysfunction. [144,145] Mitochondria-related glycolysis, the tricarboxylic acid (TCA) cycle, β-oxidation, and OXPHOS were decreased in the elderly population. [146] Besides, aging is associated with obesity-independent insulin resistance and involves disrupted mitochondrial structure and dysregulated cellular insulin action.…”

Section: Metabolism Dysfunctionmentioning

confidence: 99%

Pancreatic adenocarcinoma and aging: understanding the menace for better management

Zhou

Jin

Hao

et al. 2023

Journal of Pancreatology

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Pancreatic ductal adenocarcinoma (PDAC) is the leading cause of cancer-related death worldwide. As PDAC is more common in older adults and the population is aging, the incidence of pancreatic adenocarcinoma is expected to increase in the coming years. As a result, the mechanism and clinical management of PDAC in the elderly population is receiving more attention. This review will discuss age-related morphological and pathological changes, clinical management, surgery and adjuvant therapies, and molecular changes in elderly PDAC patients. More research is needed to clarify molecular mechanisms and develop new prevention and treatment strategies for PDAC in elderly patients.

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Metabolic changes in aging humans: current evidence and therapeutic strategies

Cited by 77 publications

References 123 publications

Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats

Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats

Program Peningkatan Pengetahuan untuk Lansia dengan Sindroma Metabolik di Cimahi

Pancreatic adenocarcinoma and aging: understanding the menace for better management

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