Present status of Accelerator-Based BNCT

Kreiner, Andrés J.; Bergueiro, J.; Cartelli, D.; Baldo, M.; Castell, W.; Asoia, Javier Gómez; Padulo, J.; Sandin, J.C. Suarez; Igarzábal, M.; Erhardt, J.; Mercuri, Daniel; Valda, A.A.; Minsky, D.M.; Debray, M. E.; Somacal, H.; Capoulat, M.E.; Herrera, María S.; Grosso, M.F. del; Gagetti, Leonardo; Anzorena, M. Suarez; Canepa, N.; Real, Nicolas; Gun, Marcelo; Tacca, H.

doi:10.1016/j.rpor.2014.11.004

Cited by 116 publications

(79 citation statements)

References 25 publications

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“…Recently, a number of proton accelerator-based neutron sources have been commissioned for research and clinical use [57], opening new perspectives for the potential development of BNCT as a viable new cancer therapy modality.…”

Section: Discussionmentioning

confidence: 99%

Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

Varès

Jallet²,

Matsumoto

et al. 2018

Preprint

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AbstractTreatment resistance, relapse and metastasis remain critical issues in some challenging cancers, such as chondrosarcomas. Boron-neutron Capture Therapy (BNCT) is a targeted radiation therapy modality that relies on the ability of boron atoms to capture low energy neutrons, yielding high linear energy transfer alpha particles. We have developed an innovative boron-delivery system for BNCT, composed of multifunctional fluorescent mesoporous silica nanoparticles (B-MSNs), grafted with an activatable cell penetrating peptide (ACPP) for improved penetration in tumors and with Gadolinium for magnetic resonance imaging (MRI) in vivo. Chondrosarcoma cells were exposed in vitro to an epithermal neutron beam after B-MSNs administration. BNCT beam exposure successfully induced DNA damage and cell death, including in radio-resistant ALDH+ cancer stem cells (CSCs), suggesting that BNCT using this system might be a suitable treatment modality for chondrosarcoma or other hard-to-treat cancers.

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Section: Discussionmentioning

confidence: 99%

Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

Varès

Jallet²,

Matsumoto

et al. 2018

Preprint

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“…In order to overcome this problem, accelerator‐based neutron sources are being developed with the anticipation of easier introduction into hospitals and being less expensive than a dedicated nuclear reactor. Generally, they produce low‐intensity neutron fluxes compared with reactor sources, and an increase in intensity by more than an order of magnitude would be required . However, recently, an accelerator that generates thermal neutrons with sufficient energy has been developed.…”

Section: Boron Neutron Capture Therapymentioning

confidence: 99%

Current treatment, particle radiotherapy, and boron neutron capture therapy for advanced oral cancer in patients

Yura

Tada

Fujita

et al. 2019

Oral Science International

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Malignant tumors such as squamous cell carcinoma (SCC), malignant salivary gland tumor, mucosal melanoma, sarcoma, and lymphoma occur in the oral cavity. Among them, oral SCC accounts for 90%. The frequency of lymph node metastasis of oral SCC varies depending on the site of occurrence, which affects the prognosis. Surgery is the primary treatment for oral cancer, but when the tumor extends, postoperative radiation with or without chemotherapy is required. Photons including X-rays and γ-rays are the most widely used types of ionizing radiation in cancer radiotherapy. Particle radiotherapy using protons and carbon ions shows a highly focused dose distribution to tumor tissues. Carbon ion therapy is effective for salivary gland tumors, malignant melanomas, and sarcomas which are less susceptible to photons. Furthermore, boron neutron capture therapy with tumor selectivity is expected to further reduce damage to surrounding normal cells. The introduction of novel radiotherapy to current treatment might improve the prognosis of patients and organ preservation. K E Y W O R D S chemotherapy, oral cancer, particle radiotherapy, radiotherapy, surgery How to cite this article: Yura Y, Tada S, Fujita Y, Hamada M. Current treatment, particle radiotherapy, and boron neutron capture therapy for advanced oral cancer in patients. Oral Sci Int. 2019;16:49-68. https://doi.

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“…Para que a NCT seja efetiva, é necessário que o fluxo de nêutrons na região de tratamento seja superior a 10 9 n.cm -2 .s -1 , para que a fluência desejada de 10 12 n.cm -2 possa ser atingida em menos de uma hora 13 . Para atingir tais condições de irradiação, reatores nucleares e aceleradores de partículas constituem-se como as duas fontes de irradiação disponíveis para uso em BNCT.…”

Section: Fonte De Nêutronsunclassified

“…Nesse sentido, a comunidade internacional tem investido há algum tempo no desenvolvimento e na construção de aceleradores para uso em BNCT. Contudo, não há ainda um consenso quanto às melhores configurações de máquina, variando-se os sistemas aceleradores e a reação de produção de nêutron, além da energia do feixe primário 13 .…”

Section: Fonte De Nêutronsunclassified

Princípios e aplicações da Terapia por Captura de Nêutrons por Boro – BNCT

Siqueira¹,

Yoriyaz²,

Shorto³

et al. 2019

Rev Bras Fis Med

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ResumoA terapia por captura de nêutrons (neutron capture therapy -NCT) é uma técnica radioterápica bimodal com princípios de funcionamento muito vantajosos para o tratamento de cânceres difusos. Contudo, apesar dessa vantagem conceitual e de sua primeira proposição já exceder 80 anos, essa técnica ainda não se encontra consolidada na comunidade clínica internacional como proposta terapêutica. Esse insucesso em seu estabelecimento não tem impedido que diversos grupos de pesquisa de diversos países do mundo invistam tempo e recursos em seu desenvolvimento. Neste texto apresentamos brevemente um histórico da NCT e dos principais desafios enfrentados pelos diversos grupos de pesquisas, uma comunidade de entusiastas da técnica, no seu desenvolvimento e na consolidação terapêutica da sua vertente mais estudada, a boron neutron capture therapy (BNCT). É apresentado também um resumo dos principais resultados alcançados com a técnica, além de um breve relato dos estudos realizados na instalação experimental de BNCT no Brasil. Palavras-chave: terapia por captura de nêutrons; boron neutron capture therapy; radioterapia; carregadores; fonte de nêutrons. AbstractNeutron Capture Therapy (NCT) is a bimodal radiotherapy technique with very advantageous operating principles for the treatment of diffuse cancer cells. However, despite its conceptual advantage and its already exceeding 80-year proposition time, NCT has not yet been consolidated in the international clinical community as a therapeutic alternative. The failure in its incorporation as a therapeutic procedure has not prevented several research groups from many countries around the world to have invested time and resources in its development. In this text, we briefly present a history of the NCT, and the main challenges faced by the various research groups, which form a community of enthusiasts of the technique, in its development and therapeutic consolidation of its most studied branch, the Boron Neutron Capture Therapy (BNCT). A summary of the main results achieved with the technique and a brief report of the studies carried out at the BNCT experimental facility in Brazil was also presented

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Present status of Accelerator-Based BNCT

Cited by 116 publications

References 25 publications

Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

Current treatment, particle radiotherapy, and boron neutron capture therapy for advanced oral cancer in patients

Princípios e aplicações da Terapia por Captura de Nêutrons por Boro – BNCT

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