Prescription Patterns of Antihypertensive Drugs and Adherence to JNC Vii Guidelines in a Tertiary Care Hospital in North India

Introduction: Several studies show that the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been associated with hypertension in various populations. The present study sought to determine the association of the I/D gene polymorphism among Malay male essential hypertensive subjects in response to ACE inhibitors (enalapril and lisinopril). Materials and methods: A total of 72 patients with newly diagnosed hypertension and 72 healthy subjects were recruited in this study. Blood pressure was recorded from 0 to 24 weeks of treatment with enalapril or lisinopril. Genotyping of the I/D polymorphism was carried out using a standard PCR method. Results: Statistically significant association of the D allele of the ACE gene was observed between the case and control subjects (p < 0.01). There was a decrease in blood pressure in the patients carrying the DD genotype (SBP=18.5±8.1 mmHg, DBP=15.29±7.1 mmHg) rather than the ID (SBP=4.1±3.3 mmHg, DBP=9.1±3.5 mmHg) and II genotypes (SBP= 3.0±0.2 mmHg, DBP 0.11±6.1 mmHg) of the ACE gene. Conclusion: Patients carrying the DD genotype had higher blood pressure-lowering response when treated with ACE inhibitors enalapril or lisinopril than those carrying ID and II genotypes, suggesting that the D allele may be a possible genetic marker for essential hypertension among Malay male subjects.

show abstract

A Prospective Study of Prescribing Pattern of Antihypertensive Drugs in Tertiary Care Hospital, Bangalore

Kalamdani¹,

Bhandare²

2013

jemds

View full text Add to dashboard Cite

BACKGROUND: Hypertension is the most common cardiovascular disease. Sustained arterial hypertension damages blood vessels in kidney, heart, brain and leads to an increased incidence of renal failure, coronary disease, heart failure and stroke. Effective pharmacologic lowering of blood pressure has been shown to prevent damage to blood vessel and so substantially reduce morbidity and mortality rates.AIM: This drug utilization study was intended to find out the preferred drug group prescribed either alone or in combinations and their adherence to the JNC7 guidelines. Furthermore the prescription variations as regards to the age and concomitant illness were also analyzed. METHODS AND MATERIAL: Drug utilization data were analyzed after getting the patient's particulars regarding age, sex, drugs, concomitant illness etc. in the proforma. RESULTS: After analysis, it was found that most frequently prescribed antihypertensive drugs were ARBs (58%), CCBs (50%), Beta blockers(15%), Diuretics (14%). 68% received monotherapy while remaining 32% received combination therapy. CONCLUSION: The prescription pattern was found to be partly in accordance with JNC VII guidelines.

show abstract

Prescription Patterns of Antihypertensive Drugs and Adherence to JNC Vii Guidelines in a Tertiary Care Hospital in North India

Cited by 6 publications

References 7 publications

Comparative Effect of Racemic Amlodipine and its Enantiomer with Atenolol on Hypertensive Patients—A Randomized, Open, Parallel Group Study

Comparative Effect of Racemic Amlodipine and its Enantiomer with Atenolol on Hypertensive Patients—A Randomized, Open, Parallel Group Study

Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene among Malay male hypertensive subjects in response to ACE inhibitors

A Prospective Study of Prescribing Pattern of Antihypertensive Drugs in Tertiary Care Hospital, Bangalore

Contact Info

Product

Resources

About