“…[1][2][3] While the common practice of using off-label drugs in pediatrics is widely recognized as medically necessary, the lack of pediatric research and knowledge in the area of pediatric evidencebased treatment is of real concern. 4,5 When drugs are studied rigorously in children, it is clear that dosage regimes based on age, weight, and body surface area do not reflect actual pharmacokinetics of the drugs across the various stages of pediatric development.…”