Preradiotherapy Computed Tomography as a Predictor of Local Control in Supraglottic Carcinoma

Abstract

Pretreatment CT measurements of tumor volume permits stratification of patients with supraglottic SCC treated with RT alone (which allows preservation of laryngeal function) into groups in which local control is more likely and less likely. Pre-epiglottic space spread is not a contraindication to using RT as the primary treatment for supraglottic SCC.

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

“…Plataniotis et al [29] found that GTV correlated with treatment outcomes for patients with locally advanced HNSCC treated with radiation therapy or radiation therapy plus chemo therapy. Several authors also reported that GTV obtained from CT scan was a significant predictor for clinical outcome in the treatment of HNSCC [10,[30][31][32]. A few articles suggested that the larger MR-derived GTV was associated with higher recurrence and poorer survival rates [33,34].…”

Interobserver reliability of computed tomography‐derived primary tumor volume measurement in patients with supraglottic carcinoma

“…GTV appears to be the strongest independent predictor of local failure after RT. 9 Pretreatment CT measurements of GTV permit stratification of local control in patients with SGSCCA who receive treatment with RT alone. Mancuso et al reported local control rates of 89% in tumors Ͻ 6 cc and 52% when tumor volumes were Ն 6 cc.…”

“…[5][6][7][8][9][10][11][12][13][14][15][16][17] Threshold volumes have been identified in nasopharyngeal, oropharyngeal, supraglottic, pyriform sinus, and T3 glottic carcinomas. [5][6][7][8][9][10][11][12][13][14][15][16][17] Several investigators also have shown that there is a stronger association between GTV and local control than the association between T classification and local control. 6,7,[15][16][17][18] This additional information helps physicians to counsel patients regarding the relative likelihood of local tumor control with primary surgery or RT with or without chemotherapy.…”

“…4 Numerous studies have shown that the macroscopic ("gross") tumor volume (GTV) at the primary site, as calculated from pretreatment computed tomography (CT) scans, can predict local control in squamous cell carcinoma (SCC) arising in different subsites of the head and neck in patients who are treated with definitive radiation therapy (RT). [5][6][7][8][9][10][11][12][13][14][15][16][17] Larger volume tumors have a higher likelihood of local recurrence than smaller volume lesions arising in the same anatomic subsite. [5][6][7][8][9][10][11][12][13][14][15][16][17] Threshold volumes have been identified in nasopharyngeal, oropharyngeal, supraglottic, pyriform sinus, and T3 glottic carcinomas.…”

“…[5][6][7][8][9][10][11][12][13][14][15][16][17] Larger volume tumors have a higher likelihood of local recurrence than smaller volume lesions arising in the same anatomic subsite. [5][6][7][8][9][10][11][12][13][14][15][16][17] Threshold volumes have been identified in nasopharyngeal, oropharyngeal, supraglottic, pyriform sinus, and T3 glottic carcinomas. [5][6][7][8][9][10][11][12][13][14][15][16][17] Several investigators also have shown that there is a stronger association between GTV and local control than the association between T classification and local control.…”