Preperitoneal Fat Tissue May Be Associated with Arterial Stiffness in Obese Adolescents

Hacıhamdioğlu, Bülent; Öçal, Gönül; Berberoğlu, Merih; Şıklar, Zeynep; Fítöz, Suat; Tutar, Ercan; Nergisoglu, G.; Erdeve, Şenay Savaş; Çamtosun, Emine

doi:10.1016/j.ultrasmedbio.2013.11.014

Cited by 18 publications

(17 citation statements)

References 41 publications

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“…2,19 Our findings are consistent with the results of previous studies, in which children and adolescents with overweight/obesity presented with higher values of PWV than their peers with normal body weight. 8,9,20 One previous study demonstrated a correlation between PWV and continuous metabolic syndrome score in Indian children. 21 This evidence suggests that obesity may be an independent factor affecting the status of the vascular wall.…”

Section: Discussionmentioning

confidence: 99%

“…Other authors have documented associations between PWV and other markers of cardiovascular risk such as preperitoneal fat tissue thickness and waist/hip circumference. 8,22 However, we did not include these parameters in our analysis.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Furthermore, the results of the sparse available studies dealing with the problem in question are inconclusive. [7][8][9] The issue whether hypertension changes central aortic pressure parameter values remains open.…”

Section: Introductionmentioning

confidence: 99%

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Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Wójtowicz¹,

Łempicka²,

Łuczyński³

et al. 2017

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Wójtowicz¹,

Łempicka²,

Łuczyński³

et al. 2017

Adv Clin Exp Med

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“…12,23,27,30,32 Six of these studies determined PWV using the carotid-femoral wave forms gated to the ECG, 12,21,24,27,30,32 2 studies used Doppler ultrasound traces from the ascending and descending aorta, 23,25 whereas 4 studies used a single-point method of PWV determination using carotid β stiffness, diastolic blood pressure, and blood density. 19,20,22,26 There were 4 studies assessing carotid β stiffness, 19,20,26,28 all reporting a higher carotid β stiffness index in the children with obesity. Similarly, in the 4 studies assessing aortic β stiffness, 25,27,29,31 all reported a higher aortic β stiffness index in the children with obesity.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Obesity and Arterial Stiffness in Children

Coté

Phillips

Harris

et al. 2015

ATVB

130

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Objective-Childhood obesity is associated with risk factors for cardiovascular disease. Arterial stiffness is considered one of the earliest detectable measures of vascular damage. There is controversy in the literature regarding the effects of childhood obesity on arterial stiffness. The objective of this study is to systematically review the literature and to conduct a meta-analysis comparing measures of central arterial stiffness in children and adolescents with obesity to healthy body mass index controls. Approach and Results-Literature searches were conducted using databases (eg, MEDLINE, EMBASE) and citations cross-referenced. Studies assessing central pulse wave velocity or β-stiffness index were included. A random effects meta-analysis of the standardized mean difference and 95% confidence intervals in arterial stiffness between children with obesity and control children was performed for each arterial stiffness measure. A total of 523 studies were identified. Fifteen case-control studies were included, with 2237 children/adolescents (1281 with obesity, 956 healthy body mass index controls) between 5 and 24 years of age. All studies measuring carotid and aortic β-stiffness index and 10/12 studies measuring central pulse wave velocity reported greater arterial stiffness in children/adolescents with obesity compared with controls. A random effects meta-analysis was performed revealing a significant effect of obesity on pulse wave velocity (standardized mean difference=0.718; 95% confidence interval=0.291-1.415), carotid β-stiffness index (0.862; 0.323-1.402), and aortic β stiffness index (1.017; 0.419-1.615). Conclusion-These findings indicate that child/adolescent obesity is associated with greater arterial stiffness. However, further research is needed to address confounders, such as pubertal status, that may affect this relationship in children. In the future, these techniques may be useful in risk stratification and guiding clinical management of obese children to optimize cardiovascular outcomes.

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“…The adipose tissue distribution during pregnancy showed a tendency towards a decreased accumulation of the subcutaneous and an increased accumulation of the preperitoneal adipose tissue [14]. It was also concluded that PAT may be related to arterial stiffness [15]. The hypothesis that the ratio of the visceral to the subcutaneous adipose tissue is associated with altered sepsis outcome has been recently partially proved [16].…”

Section: Introductionmentioning

confidence: 98%

SEM (EDX) is an indispensable tool for the characterization of subcutaneous, preperitoneal and visceral adipose tissue of obese patients

Skaudžius¹,

Misevicius²,

Brimienė³

et al. 2018

chemija

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In this work the scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) elemental analysis were used for the characterization of adipose tissue samples taken from volunteer obese patients. The adipose tissue was taken from subcutaneous, preperitoneal and visceral layers of the adipose tissue. The obtained results provided information about the structural composition of adipose tissue layers in the human body, as well as the main microstructural features. It was demonstrated for the first time, to the best of our knowledge, that SEM and EDX are indispensable tools in order to investigate some special morphological features and the elemental composition of different layers of the human adipose tissue, identifying the surface microstructure and its qualitative composition. From the obtained results we concluded that such characterization of the adipose tissue is an essential step for the possible prediction of symptoms of different diseases.

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Preperitoneal Fat Tissue May Be Associated with Arterial Stiffness in Obese Adolescents

Cited by 18 publications

References 41 publications

Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Obesity and Arterial Stiffness in Children

SEM (EDX) is an indispensable tool for the characterization of subcutaneous, preperitoneal and visceral adipose tissue of obese patients

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