Preparation, structure analysis and ACE inhibitory activity of konjac oligosaccharide

Song, Qi; Li, Ting; Xue, Wei; Li, Nan; Chen, Lin-Ting; Dai, Shuhan; Zhu, Zhiwei

doi:10.1016/j.indcrop.2018.08.034

Cited by 24 publications

(10 citation statements)

References 14 publications

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“…The other analysis results suggest that KA was linked to the KGO molecular chain through a covalent bond, and the reaction site of KA was the methyl group. Hydrophilicity is a major feature of KGO [36]. Compared with KGO, the antimicrobial activity of KGOK was significantly enhanced.…”

Section: Discussionmentioning

confidence: 98%

Synthesis, Antimicrobial, Moisture Absorption and Retention Activities of Kojic Acid-Grafted Konjac Glucomannan Oligosaccharides

et al. 2019

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Kojic acid (KA) with antibacterial activities produced by fermentation was grafted onto konjac glucomannan oligosaccharide (KGO) composed of glucose and mannose linked by β-1,4 glycosidic bonds. A novel KGO derivative, konjac glucomannan oligosaccharide kojic acid (KGOK) possessing both moisture retention and antibacterial activities was synthesized. The structure of KGOK was characterized and analyzed by thermogravimetric analysis (TG), XRD, UV-vis absorption, FTIR, and 1 H NMR. The analysis results suggest that KA was linked to the KGO molecular chain through a covalent bond, and the reaction site of KA was the methylol group. The studies demonstrate that KGOK maintained the excellent moisture absorption and retention properties of KGO and the good antibacterial activities of KA. The minimum inhibitory concentration (MIC) of KGOK is 2 mg/mL for Staphylococcus aureus, Staphylococcus epidermidis, Shewanella putrefaciens, and Salmonella enterica, while its MIC is 3 mg/mL for Escherichia coli. The multi-functionality of the KGOK synthesized from natural sources provides a theoretical foundation for their potential applications in the preservation of food, beverage, aquatic, and cosmetic products.Polymers 2019, 11, 1979 2 of 12 and KGO have many good properties, these functionalities can be further improved through certain molecular modifications. Various forms of KGM derivatives obtained by physical, chemical, and enzymatical modifications have been used in a range of different applications, including biodegradable films, medical and pharmaceutical materials, functional foods, and aerogel [10]. Thus, the modification of KGM and KGO gains much interest from numerous researchers because of their better performance in food applications.Kojic acid (KA), 5-hydroxy-2-hydroxymethyl-1,4-pyrone, is a weakly acidic secondary metabolite produced by aerobic fermentation of Aspergillus, Acetobacter, and Penicillium. KA has a variety of biological activities, including antibacterial, antifungal, antiviral, and antioxidant activities [16][17][18][19]. Therefore, KA and its derivatives have attracted much attention for their variety of biological activities.In aquatic product preservation, the most common challenges are water retention and bacterial inhibition. Foodborne pathogens and spoilage bacteria such as Staphylococcus aureus, Shewanella putrefaciens, Escherichia coli, and Salmonella enterica, which are common strains found in aquatic products [20][21][22]. Staphylococcus epidermidis is a bacterium that breeds on the epidermis of organisms. Most of them are non-pathogenic bacteria and a few can cause diseases. S. aureus is a commensal and opportunistic pathogen that can cause contamination of food products during preparation and processing [23]. S. putrefaciens is a marine, gram-negative bacterium which plays a role in the food industry as a spoilage bacterium of marine fish and chicken due to its ability to produce volatile sulfides, amines, and the fishy-smelling compound trimethylamine [24]. As one of the oligosaccharides...

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Section: Discussionmentioning

confidence: 98%

Synthesis, Antimicrobial, Moisture Absorption and Retention Activities of Kojic Acid-Grafted Konjac Glucomannan Oligosaccharides

et al. 2019

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“…In particular, oligosaccharides are new sugar sources that are widely used in food, medicine, agriculture, and other elds. Different from common sugar sources, the oligosaccharides can signi cantly increase the numbers of bene cial bacteria in intestinal, inhibit the spread of harmful bacteria (Ma et al, 2020), and play the role of water retention because of their highly hydrophilic properties (Song et al, 2018). Manno-oligosaccharide (MO) is a kind of functional oligosaccharides.…”

Section: Introductionmentioning

confidence: 99%

Mechanism That Allows Manno-Oligosaccharide To Promote Cellulose Degradation By Microbes And Composting of Cow Manure With Straw

Zhang

Duan

Zhou

et al. 2021

Preprint

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New sugar source, manno-oligosaccharide, can regulate the structure of microbes. The effects of adding manno-oligosaccharide at four different levels (0, 0.1%, 0.5%, and 1% w/w compost) to cow manure–straw compost on the composting process, degradation of lignocellulose, and bacterial community in this study was investigated. The results showed that adding 0.5% manno-oligosaccharide had the greatest effects on accelerating the composting process, reducing the toxicity, and improving the stability of the product. After composting for 25 days, 0.5% oligosaccharide treatment can decrease the hemicellulose, cellulose, and lignin contents to 2.25%, 11.25%, and 7.07% respectively, compared with CK. Manno-oligosaccharide affected the distribution of the bacterial community, inhibited pathogenic bacteria, and improved the abundance of functional genes. Finally, adding 0.5% manno-oligosaccharide mainly affected the degradation of lignocellulose by enhancing the C/N value and the abundances of Streptomyces and the secretion system during composting was demonstrated by redundancy analysis.

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“…Glucomannan also known to have anti-inflammation and immunomodulator activity which can be used as indirect mechanism to treat SARS-Cov-2 infection [16]. Modified GM from Amorphophallus konjac reportedly able to interact with glycoprotein of Human Immunodeficiency Virus (HIV) [17] and also shown potential as ACE inhibitor [18], however its activity as ACE2 inhibitor has never been explored before.…”

Section: Introductionmentioning

confidence: 99%

The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2

et al. 2021

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The inhibition of SARS-Cov-2 S binding with hACE2, expressed in most human tissues, may prevent the severity of virus infection. However, commercial ACE2 inhibitor drugs are still limited, while several natural compounds have already been reported to have anti-ACE2 activity. We found the potential of hydrolyzed glucomannan of porang tuber in the inhabitation of binding activity between ACE2 and S1 of SARS-Cov-2.

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Preparation, structure analysis and ACE inhibitory activity of konjac oligosaccharide

Cited by 24 publications

References 14 publications

Synthesis, Antimicrobial, Moisture Absorption and Retention Activities of Kojic Acid-Grafted Konjac Glucomannan Oligosaccharides

Synthesis, Antimicrobial, Moisture Absorption and Retention Activities of Kojic Acid-Grafted Konjac Glucomannan Oligosaccharides

Mechanism That Allows Manno-Oligosaccharide To Promote Cellulose Degradation By Microbes And Composting of Cow Manure With Straw

The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2

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