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2021
DOI: 10.29333/ejgm/11402
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The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2

Abstract: The inhibition of SARS-Cov-2 S binding with hACE2, expressed in most human tissues, may prevent the severity of virus infection. However, commercial ACE2 inhibitor drugs are still limited, while several natural compounds have already been reported to have anti-ACE2 activity. We found the potential of hydrolyzed glucomannan of porang tuber in the inhabitation of binding activity between ACE2 and S1 of SARS-Cov-2.

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Cited by 3 publications
(1 citation statement)
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References 22 publications
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“…Several studies examine the physical and chemical composition, characteristics, biological functions, extraction, and purification methods of porang (Nurlela et al, 2021(Nurlela et al, , 2022Wardhani et al, 2019Wardhani et al, , 2020Widjanarko et al, 2014;Witoyo et al, 2021Witoyo et al, , 2022Witoyo et al, , 2023Yanuriati et al, 2017). Like the konjac tuber, porang tubers contain high water-soluble polysaccharides known as glucomannan and have diverse significant roles in the medical sector, food and food additives, materials research, agriculture, and other sectors (Ulayya et al, 2022;Widjanarko et al, 2022).…”
Section: Introductionmentioning
confidence: 99%
“…Several studies examine the physical and chemical composition, characteristics, biological functions, extraction, and purification methods of porang (Nurlela et al, 2021(Nurlela et al, , 2022Wardhani et al, 2019Wardhani et al, , 2020Widjanarko et al, 2014;Witoyo et al, 2021Witoyo et al, , 2022Witoyo et al, , 2023Yanuriati et al, 2017). Like the konjac tuber, porang tubers contain high water-soluble polysaccharides known as glucomannan and have diverse significant roles in the medical sector, food and food additives, materials research, agriculture, and other sectors (Ulayya et al, 2022;Widjanarko et al, 2022).…”
Section: Introductionmentioning
confidence: 99%