Preparation, Structural Aspects and Spectroscopic [IR, NMR (1H, 13C and 119Sn)] Characterization of Certain New Penta-Coordinated Mixed Ligand Complexes of Dibutyltin(IV) of β-Diketones, Fluorinated β-Diketones and 1,3-Dihydro-1,3-Dioxo-α-Substituted-2H-Isoindole-2-Acetic Acids

Abstract

Some new mixed ligand dibutyltin(IV) complexes of the type Bu 2 SnLA [where LH = RC(0)CH 2 C(0)R', R = -QHj and R' = -CH 3 (L,H), R = -C 6 H 5 and R' = -CF^LjH), R = -C 4 H 3 S and R' = -CF 3 (L 3 H) andAH=t(0)QH4C(0)NfCHR"C00H, R"= -H(A,H), R"= -CH 3 (A 2 H),R"= -CHaQHs (A 3 H), -CHR" = -CH 2 CH 2 -(A4H)] have been prepared by the reaction of dibutyltin(IV) dichloride with the corresponding ligands in the presence of triethylamine in 1:1:1:2 molar ratios in dry refluxing THF solution. The structural elucidation of these newly synthesised complexes is based upon physico-chemical and spectroscopic studies. These complexes possess penta-coordinated tin centres as inferred from U9 Sn NMR spectral studies of some of these complexes.Brought to you by | Purdue University Libraries Authenticated Download Date | 6/1/15 12:30 AM fluorinated ß-diketones on the properties of the resulting mixed ligand organotin(IV) complexes. In this paper, we report the preparation, structural aspects and spectral studies of some mixed ligand complexes of dibutyltin(IV) of ß-diketones, fluorinated ß-diketones and N-protected amino acids. EXPERIMENTALAll the reactions were carried out under strictly anhydrous conditions. Dibutyltin(IV) dichloride (Lancaster) was distilled (135°/10mm) before use. All the solvents were dried by standard methods. Tin was estimated as tin(IV) oxide. Melting points were determined in sealed capillaries. Molecular weight measurements were carried out by determining depression in freezing point and were found to be in agreement with calculated values (Table 1). N-protected amino acids were synthesised by the method reported by Sheehan /20/. ß-Diketones were commercially available.

De novo unified robust antidiabetic pharmacophores based on biopotent hybrid material: DFT‐assisted design, optimized molecular structure, and understanding mechanism of antidiabetic bioassay

“…119 Sn NMR spectra of Complexes 1, 3, and 4 exhibit signals at −147.95, −142.37, and −141.30 ppm, respectively. These 119 Sn chemical shift values support the presence of pentacoordinated tin centers in these complexes 35,36 …”

“…These 119 Sn chemical shift values support the presence of pentacoordinated tin centers in these complexes. 35,36 T A B L E 8 Optimized data of ligand L (4) H 2 /SCM and its corresponding complex Me 2 SnL (4) /Me 2 Sn(SCM) (Complex 4).…”

Deciphering mechanistic implications of antimicrobial and antioxidant potentials of certain new dibutyltin(IV) formulations as possible therapeutic options based on DFT and hybrid materials paradigm

“…119 Sn NMR spectra of some of the representative dibutyltin(IV) formulations demonstrate signals in the region of (−181.75) to (−200.48) ppm which revealed the existence of pentacoordinated tin centers in these formulations. [ 36 ] 119 Sn NMR chemical shift values are given in Table 5.…”

Some new N-protected amino acid derivatives of phenylboronic acid: preparation, structural chemistry and insight into structural aspects based on spectroscopic studies

“…Various potential organic ligands have been used for the synthesis of organic derivatives of organoboron(III) (Singh et al, 2005;Swami et al, 2009;Yadav et al, 2010). N-Protected amino acids are an important class of organic ligands which display a diversifi ed mode of bonding (Saxena et al, 1991(Saxena et al, , 1992Surana and Saxena, 1996;Verma et al, 2004;Joshi et al, 2005;Sharma et al, 2007;Gupta et al, 2009) and their metal complexes exhibit signifi cant biological activities (Saxena et al, 1991). In view of the interesting results obtained in our previous communications (Gupta et al, 2010a,b;Sharma et al, 2010) and as an extension of our ongoing research work concerning the synthesis of organic derivatives of some trivalent and tetravalent elements, it was considered relevant to study the ligating capability of N-protected amino acids towards PhB(OH) 2 .…”