The study was focused on the structure-activity relationship of some newly synthesized hexacoordinated dimethyltin(IV) complexes of fluorinated β-diketone/β-diketones and sterically congested heterocyclic β-diketones. These complexes were screened for their antibacterial activity against a Gram-negative bacterium (Pseudomonas aeruginosa) and Gram-positive bacteria (Streptomyces griseus, Staphylococcus aureus, Bacillus subtilis) and the results were compared with those of a standard antibacterial drug. Some of the complexes were also screened for their antifungal activity against various fungi (Aspergillus niger, A. flavus, Trichoderma viride, Fusarium oxysporum) and were found to be active. These new hexacoordinated complexes of dimethyltin (IV) were generated by reactions of dimethyltin(IV) dichloride and sodium salts of fluorinated β-diketone/β-diketones and sterically congested heterocyclic β-diketones in 1:1:1 molar ratio in refluxing dry benzene. Plausible structures of these complexes were suggested with the aid of physicochemical and spectroscopic studies. 119 Sn NMR spectral data revealed the presence of a hexacoordinated tin centre in these dimethyltin(IV) complexes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.