Preparation of α- and β-tricalcium phosphate ceramics, with and without magnesium addition

Famery, Roger; Richard, N.; Boch, P.

doi:10.1016/0272-8842(94)90050-7

Cited by 135 publications

(61 citation statements)

References 13 publications

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“…The addition of MgO to ␤-TCP was found to enable sintering of ␤-TCP, without phase transition, at a higher temperature than that of MgO-free ␤-TCP. 14,15 In addition, when ␤-TCP with low Ca/P ratio was sintered at 1300°C, little conversion into ␣-TCP occurred. 16 Ryu et al reported that ␤-TCP doped with calcium pyrophosphate induced a phase transformation to ␣-TCP at 1250°C.…”

Section: Introductionmentioning

confidence: 98%

Characterization and bioactivity of tape‐cast and sintered TCP sheets

Tanimoto

Hayakawa

Tanaka

et al. 2005

J Biomedical Materials Res

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The purpose of this study was to investigate the influence of sintering temperature on in vivo and in vitro bioactivities of sintered tricalcium phosphate (TCP) sheets prepared by the tape casting technique. Green sheets of beta-TCP prepared by tape casting were sintered for 2 h in a furnace at atmospheric pressure, at five different sintering temperatures: 900, 1000, 1100, 1150, and 1200 degrees C. Measurement of X-ray diffraction and Fourier transform infrared spectrometry showed the presence of alpha-tricalcium phosphate phase in the TCP sheet sintered at 1200 degrees C, in addition to beta-TCP phase. As compared with the other sintered TCP sheet, the TCP sheet sintered at 1200 degrees C demonstrated a lower dissolution rate in phosphate buffered saline solution at 37 degrees C and pH 7.4 over 24 weeks, and more amount of apatite formation in Hanks' balanced salt solution with pH 7.4 was observed. After 4 weeks' implantation of sintered TCP sheets into tibial diaphyses of rabbits, the bone-sheet contact of the TCP sheet sintered at 1200 degrees C was significantly higher than that of the TCP sheet sintered at 900 degrees C. These results indicate that a flat sintered TCP sheet prepared by tape casting is a promising material for a bone substitute.

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Section: Introductionmentioning

confidence: 98%

Characterization and bioactivity of tape‐cast and sintered TCP sheets

Tanimoto

Hayakawa

Tanaka

et al. 2005

J Biomedical Materials Res

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“…The bioresorption rate was also controlled by the coexistence of a-with b-TCP, based on their different degradation rates. Famery et al (1994) reported a fabrication process for TCP ceramics with the a-and b-TCP ratio being controlled by the addition of magnesium. We (Oishi et al 2004;Kamitakahara et al 2005a) attempted the fabrication of TCP porous ceramics with a-and b-TCP ratios controlled by the addition of Mg, Zn and Fe because additives such as Mg (Ando 1958) and Zn (Kreidler & Hummel 1967) raise the temperature of transformation of TCP from the b-to a-phase.…”

Section: Bioresorbable Ceramicsmentioning

confidence: 99%

Bioactive ceramic-based materials with designed reactivity for bone tissue regeneration

Ohtsuki

Kamitakahara

Miyazaki

2009

J. R. Soc. Interface.

143

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Bioactive ceramics have been used clinically to repair bone defects owing to their biological affinity to living bone; i.e. the capability of direct bonding to living bone, their so-called bioactivity. However, currently available bioactive ceramics do not satisfy every clinical application. Therefore, the development of novel design of bioactive materials is necessary. Bioactive ceramics show osteoconduction by formation of biologically active bone-like apatite through chemical reaction of the ceramic surface with surrounding body fluid. Hence, the control of their chemical reactivity in body fluid is essential to developing novel bioactive materials as well as biodegradable materials. This paper reviews novel bioactive materials designed based on chemical reactivity in body fluid.

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“…In the case of synthetic materials used for repairing bone tissue, some of the most widely used clinically are calcium phosphates (CaP), which are well tolerated by the body due to their chemical homology to native bone mineral (Bohner et al, 2012). CaP provide a particularly flexible platform for material design because the physicochemical and topographical characteristics can be tuned by modifying their synthesis parameters (Osborn and Newesely, 1980;Famery et al, 1994;Dorozhkin, 2010). Of these materials, a small subset can stimulate the formation of bone even in heterotopic, non-bony locations without exogenous cells or growth factors (LeGeros, 2008;Barradas et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Submicron-scale surface architecture of tricalcium phosphate directs osteogenesis in vitro and in vivo

Davison

Luo²,

Schoenmaker³

et al. 2014

eCM

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A current challenge of synthetic bone graft substitute design is to induce bone formation at a similar rate to its biological resorption, matching bone's intrinsic osteoinductivity and capacity for remodelling. We hypothesise that both osteoinduction and resorption can be achieved by altering surface microstructure of beta-tricalcium phosphate (TCP). To test this, two TCP ceramics are engineered with equivalent chemistry and macrostructure but with either submicron-or micron-scale surface architecture. In vitro, submicron-scale surface architecture differentiates larger, more active osteoclasts -a cell type shown to be important for both TCP resorption and osteogenesis -and enhances their secretion of osteogenic factors to induce osteoblast differentiation of human mesenchymal stem cells. In an intramuscular model, submicrostructured TCP forms 20 % bone in the free space, is resorbed by 24 %, and is densely populated by multinucleated osteoclast-like cells after 12 weeks; however, TCP with micron-scale surface architecture forms no bone, is essentially not resorbed, and contains scarce osteoclast-like cells. Thus, a novel submicron-structured TCP induces substantial bone formation and is resorbed at an equivalent rate, potentially through the control of osteoclast-like cells.

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Preparation of α- and β-tricalcium phosphate ceramics, with and without magnesium addition

Cited by 135 publications

References 13 publications

Characterization and bioactivity of tape‐cast and sintered TCP sheets

Characterization and bioactivity of tape‐cast and sintered TCP sheets

Bioactive ceramic-based materials with designed reactivity for bone tissue regeneration

Submicron-scale surface architecture of tricalcium phosphate directs osteogenesis in vitro and in vivo

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