Preparation of stable aqueous suspension of a hydrophobic drug with polymers

Terayama, Hideo; Inada, Katsuhiro; Nakayama, Hisayuki; Yasueda, Shin-ichi; Esumi, Kunio

doi:10.1016/j.colsurfb.2004.09.005

Cited by 30 publications

(19 citation statements)

References 11 publications

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“…On the other hand, a marginal decrease (2-8 • C) in melting point was observed. This is because the drug particles in polymer systems had less affinity toward each other due to decreased inter-molecular forces [39]. Fig.…”

Section: Melting Point and Particle Morphologymentioning

confidence: 99%

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Meng

Chen

Chowdhury

et al. 2009

Colloids and Surfaces B: Biointerfaces

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Section: Melting Point and Particle Morphologymentioning

confidence: 99%

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Meng

Chen

Chowdhury

et al. 2009

Colloids and Surfaces B: Biointerfaces

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“…The large number of hydroxyl groups is capable of forming hydrogen bonds with resveratrol particle surface. Besides, the aqueous solubility of hydrophobic matter can be changed by the addition of polymers (Terayama, Inada, Nakayama, Yasueda, & Esumi, 2004). PVP is highly soluble in water, so it might increase the solubility of resveratrol in water.…”

Section: Selection Of Polymersmentioning

confidence: 99%

Resveratrol nanodispersion with high stability and dissolution rate

Zhang

Wang

et al. 2013

LWT - Food Science and Technology

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“…Most reports indicate that nucleation and crystal growth are delayed due to drug-polymer interactions in solution and by adsorption of the polymer on the nucleus or the growing crystal. [58,94,95] Some polymers that have been thoroughly investigated for their stabilizing characteristics are PVP, PEG, methylcellulose (MC) and HPMC. [57][58][59]93] Above their critical micellar concentration, surfactants will solubilize poorly soluble compounds and thereby decrease the degree of supersaturation.…”

Section: Crystal Growthmentioning

confidence: 99%

Review: physical chemistry of solid dispersions

2009

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Objectives With poorly soluble drug candidates emerging in the drug discovery pipeline, the importance of the solid dispersion formulation approach is increasing. This strategy includes complete removal of drug crystallinity, and molecular dispersion of the poorly soluble compound in a hydrophilic polymeric carrier. The potential of this technique to increase oral absorption and hence bioavailability is enormous. Nevertheless, some issues have to be considered regarding thermodynamic instability, as well in supersaturated solutions that are formed upon dissolution as in the solid state. Key findings After a brief discussion on the historical background of solid dispersions and their current role in formulation, an overview will be given on the physical chemistry and stability of glass solutions as they form supersaturated solutions, and during their shelf life. Conclusions Thorough understanding of these aspects will elicit conscious evaluation of carrier properties and eventually facilitate rational excipient selection. Thus, full exploitation of the solid dispersion strategy may provide an appropriate answer to drug attrition due to low aqueous solubility in later stages of development.

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Preparation of stable aqueous suspension of a hydrophobic drug with polymers

Cited by 30 publications

References 11 publications

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Resveratrol nanodispersion with high stability and dissolution rate

Review: physical chemistry of solid dispersions

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