Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Influence of polymer–surfactant interactions on o/w emulsion properties and microcapsule formation

“…Hydroxypropylmethyl cellulose (HPMC), a water-soluble nonionic derivative of cellulose, is physiologically harmless and suitable for the use in food, cosmetics and pharmaceutical preparations [17][18][19]. The presence of hydroxypropyl and methyl groups in HPMC renders the cellulose molecule hydrophobic and thus it acquires surface active properties [20].…”

Synthesis and immobilization of micro-scale drug particles in cellulosic films

“…Sonication-assisted anti-solvent precipitation was used in the synthesis of submicron and micron size particles of GF [7,23]. Nucleation and condensation tended to be competing factors as both consumed solute molecules, while coagulation led to aggregation [24][25][26].…”

“…In this project we used HPMC-LM and SDS to sterically stabilize the drug particles, thus preventing aggregation [27]. Several cellulose ethers including methyl cellulose and hydroxyethyl cellulose have been used in our previous work, and a combination of HPMC and SDS was found to be excellent for GF [7].…”

“…overall particle size [7]. Besides providing colloidal stability, these materials can also be used for the synthesis of drug delivery vehicles including biocompatible films, which have shown enormous potential [8,9].…”

Effect of solvents on stabilization of micro drug particles

“…Antisolvent precipitation of hydrophobic drugs involves contact of an aqueous phase with an organic solution containing the drug [13]. Our group has been working on the sonication assisted antisolvent methods for the synthesis of submicron and micron size particles of insoluble drug moieties [14]. The three basic steps involved in such a process is supersaturation, nucleation and particle growth [15].…”