Resveratrol nanodispersion with high stability and dissolution rate

Zhang, Xiaoping; Le, Yuan; Wang, Jie‐Xin; Zhao, Hong; Chen, Jianfeng

doi:10.1016/j.lwt.2012.07.041

Cited by 43 publications

(17 citation statements)

References 27 publications

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“…4A). Similar findings were also observed in other RES nanoparticle formulations prepared by synthetic or semi-synthetic excipients (Lee et al, 2012;Zhang, Le, Wang, Zhao, & Chen, 2013).…”

supporting

confidence: 88%

Controlled formation and stabilization of nanosized colloidal suspensions by combination of soy protein and biosurfactant stevioside as stabilizers

et al. 2016

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“…4A). Similar findings were also observed in other RES nanoparticle formulations prepared by synthetic or semi-synthetic excipients (Lee et al, 2012;Zhang, Le, Wang, Zhao, & Chen, 2013).…”

supporting

confidence: 88%

Controlled formation and stabilization of nanosized colloidal suspensions by combination of soy protein and biosurfactant stevioside as stabilizers

et al. 2016

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“…The reason is that the cloud point of Cremophor RH40 is 44°C,when the temperature is higher than the cloud point of Cremophor RH40, irreversible phase separation occurs, which lead to become a darker solution. In addition, the Res content was reduced due to the instability of Res at 60°C[34], The effect of exposure to light on the stability of the SMEDDS is shown in Table 6, under long-term illumination (4500Lx), the Res drug loading of the Res SMEDDS decreased on the 10th day due to the light instability of Res[35]. Therefore, the Res SMEDDS should be stored in the dark below 40°C.…”

Section: Resultsmentioning

confidence: 99%

Preparation and in vitro performance evaluation of resveratrol for oral self-microemulsion

Tang

Xiang

et al. 2019

PLoS ONE

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The purpose of this study was to improve the solubility of resveratrol (Res) by a self-microemulsifying drug-delivery system (SMEDDS). Through a solubility experiment, the pseudoternary phase diagram and ternary phase diagram were used to optimize the Res SMEDDS formula. The optimum formulation consisted of 5% IPM, 20% PEG400, and 65% Cremophor RH40. The water solubility, stability, in vitro release and antioxidant activity of the Res SMEDDS were characterized. The Res solubility in the SMEDDS was at least 1,000 times compared to that in water. The average droplet size of the microemulsion was 28.00±1.67 nm and uniform distribution. The Res SMEDDS should be stored at low temperature and in the dark to avoid light conditions. Res SMEDDS was able to improve the in vitro release rate of Res, and the in vitro release of Res from Res SMEDDS was significantly faster that of Res powder and unaffected by pH value of media. Antioxidant assays showed that antioxidant activities of Res in Res SMEDDS were unaffected compared to Res powder. Cytotoxicity study indicated that Res SMEDDS at the concentration of less than 100 μM was safe. These results demonstrated the potential use of Res SMEDDS for oral administration of Res.

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“…Aqueous solubility of resveratrol was found to be 30 μ g/mL, thereby, limiting pharmaceutical potential of resveratrol [ 85 ]. Zhang et al [ 86 ] reported a method for enhancing solubility of resveratrol by formulating nanoparticles of resveratrol using antisolvent precipitation method. The ethanolic solution of resveratrol (solvent) was poured with vigorous stirring (9000 rpm) into aqueous solution of polymer (antisolvent) resulting into precipitation of resveratrol after 30 s. Four different polymers that is, HPMC, PVP, PEG 400, and P188 were employed.…”

Section: Polyphenols: Types and Methods For Solubility Enhancementmentioning

confidence: 99%

A Critical Appraisal of Solubility Enhancement Techniques of Polyphenols

Kaur

2014

Journal of Pharmaceutics

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Polyphenols constitute a family of natural substances distributed widely in plant kingdom. These are produced as secondary metabolites by plants and so far 8000 representatives of this family have been identified. Recently, there is an increased interest in the polyphenols because of the evidence of their role in prevention of degenerative diseases such as neurodegenerative diseases, cancer, and cardiovascular diseases. Although a large number of drugs are available in the market for treatment of these diseases, however, the emphasis these days is on the exploitation of natural principles derived from plants. Most polyphenols show low in vivo bioavailability thus limiting their application for oral drug delivery. This low bioavailability could be associated with low aqueous solubility, first pass effect, metabolism in GIT, or irreversible binding to cellular DNA and proteins. Therefore, there is a need to devise strategies to improve oral bioavailability of polyphenols. Various approaches like nanosizing, self-microemulsifying drug delivery systems (SMEDDS), microencapsulation, complexation, and solid dispersion can be used to increase the bioavailability. This paper will highlight the various methods that have been employed till date for the solubility enhancement of various polyphenols so that a suitable drug delivery system can be formulated.

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Resveratrol nanodispersion with high stability and dissolution rate

Cited by 43 publications

References 27 publications

Controlled formation and stabilization of nanosized colloidal suspensions by combination of soy protein and biosurfactant stevioside as stabilizers

Controlled formation and stabilization of nanosized colloidal suspensions by combination of soy protein and biosurfactant stevioside as stabilizers

Preparation and in vitro performance evaluation of resveratrol for oral self-microemulsion

A Critical Appraisal of Solubility Enhancement Techniques of Polyphenols

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