Preparation of Multilayered Polymeric Structures Using a Novel Four‐Needle Coaxial Electrohydrodynamic Device

Labbaf, Sheyda; Ghanbar, Hanif; Stride, Eleanor; Edirisinghe, Mohan

doi:10.1002/marc.201300777

Cited by 74 publications

(47 citation statements)

References 25 publications

(31 reference statements)

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“…To date, the development of nanotechnologies (both 'topdown' and 'bottom-up' methods) has provided a range of useful tools for creating myriad types of complex nanoscale architectures. These include core-shell, Janus, and tri-layer nanostructures generated from both inorganic and organic materials, as well as the polymeric matrices that are frequently used in pharmaceutical applications [28][29][30][31][32][33][34][35][36]. These nanostructures can be explored to create new types of DDS including fifthgeneration SDs.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Electrospinning has been known for more than 100 years but received relatively minimal attention until the 1990s. Since then, the technique has developed very quickly from the simplest experiments using a single fluid to prepare polymer nanofibers or monolithic nanocomposites to double-fluid (coaxial and side-by-side processes) and multiple-fluid spinning (tri-axial, quarternary-axial, multiple side-byside) for producing nanostructures with increasingly complex nanoscale architectures [34,[103][104][105][106][107]. It has also developed from generating small amounts (mg) of material using a single needle to fabrication on the large (kg) scale using needless and highspeed electrospinning [108,109].…”

Section: The Electrospinning Processmentioning

confidence: 99%

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Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Williams

et al. 2018

Journal of Controlled Release

229

143

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The development of oral dosage forms for poorly water-soluble active pharmaceutical ingredients (APIs) is a persistent challenge. A range of methods has been explored to address this issue, and amorphous solid dispersions (ASDs) have received increasing attention. ASDs are typically prepared by starting with a liquid precursor (a solution or melt) and applying energy for solidification. Many techniques can be used, with the emergence of electrospinning as a potent option in recent years. This method uses electrical energy to induce changes from liquid to solid. Through the direct applications of electrical energy, electrospinning can generate nanofiber-based ASDs from drug-loaded solutions, melts and melt-solutions. The technique can also be combined with other approaches using the application of mechanical, thermal or other energy sources. Electrospinning has numerous advantages over other approaches to produce ASDs. These advantages include extremely rapid drying speeds, ease of implentation, compatibility with a wide range of active ingredients (including those which are thermally labile), and the generation of products with large surface areas and high porosity. Furthermore, this technique exhibits the potential to create so-called 'fifth-generation' ASDs with nanostructured architectures, such as core/shell or Janus systems and their combinations. These advanced systems can improve dissolution behaviour and provide programmable drug release profiles. Additionally, the fiber components and their spatial distributions can be precisely controlled. Electrospun fiber-based ASDs can maintain an incorporated active ingredient in the amorphous physical form for prolonged periods of time because of their homogeneous drug distribution within the polymer matrix (typically they comprise solid solutions), and ability to inhibit molecular motion. These ASDs can be utilised to generate oral dosage forms for poorly water-soluble drugs, resulting in linear or multiple-phase release of one or more APIs. Electrospun ASDs can also be exploited as templates for manipulating molecular self-assembly, offering a bridge between ASDs and other types of dosage forms. This review addresses the development, advantages and pharmaceutical applications of electrospinning for producing polymeric ASDs. Material preparation and analysis procedures are considered. The mechanisms through which performance has been improved are also discussed.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: The Electrospinning Processmentioning

confidence: 99%

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Williams

et al. 2018

Journal of Controlled Release

229

143

View full text Add to dashboard Cite

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“…[20][21][22][23] There are very few investigations into side-by-side electrospinning to generate Janus nanofibers, [24][25][26][27][28][29] and even fewer reports on multiple-layer nanofibers. [30][31][32][33][34][35] The slow development of multiple-fluid electrospinning processes is related to their difficulty of implementation. The successful preparation of multi-component fibers requires the spinning fluids to have good compatibility, so that they can be drawn together by electrical forces without any coagulation.…”

Section: Introductionmentioning

confidence: 99%

Nanofibers Fabricated Using Triaxial Electrospinning as Zero Order Drug Delivery Systems

Wang

et al. 2015

ACS Appl. Mater. Interfaces

249

164

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“…This has mainly been investigated in the context of monolithic fibers with one or two functional ingredients/nanoparticles distributed homogeneously in the filament-forming polymer matrix [19][20][21][22]. The second is the creation of more complex nanostructures (such as core-shell and Janus systems, and combinations thereof) in order to yield materials with improved functional performance [23][24][25][26]. In the biomedical field, if a drug reservoir could be formed as the core of electrospun core-shell fibers, then new fiber-based nanoscale drug depots could be created, such as an electrospun suture [27].…”

Section: Introductionmentioning

confidence: 99%

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

Yang

et al. 2017

Acta Biomaterialia

120

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Nanosized sustainedrelease drug depots fabricated using modified tri-axial electrospinning, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.01.069 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning Abstract:Nanoscale drug depots, comprising a drug reservoir surrounded by a carrier membrane, are much sought after in contemporary pharmaceutical research. Using cellulose acetate (CA) as a filament-forming polymeric matrix and ferulic acid (FA) as a model drug, nanoscale drug depots in the form of core-shell fibers were designed and fabricated using a modified tri-axial electrospinning process. This employed a solvent mixture as the outer working fluid, as a result of which a robust and continuous preparation process could be achieved. The fiber-based depots had a linear morphology, smooth surfaces, and an average diameter of 0.62 ± 0.07 µm. Electron microscopy data showed them to have clear core-shell structures, with the FA encapsulated inside a CA shell. X-ray diffraction and IR spectroscopy results verified that FA was present in the crystalline physical form. In vitro dissolution tests revealed that the fibers were able to provide close to zero-order release over 36 h, with no initial burst release and minimal tailing-off. The release properties of the depot systems were much improved over monolithic CA/FA fibers, which exhibited a significant burst release and also considerable tailing-off at the end of the release experiment. Here we thus demonstrate the concept of using modified tri-axial electrospinning to design and develop new types of heterogeneous nanoscale biomaterials.

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Preparation of Multilayered Polymeric Structures Using a Novel Four‐Needle Coaxial Electrohydrodynamic Device

Cited by 74 publications

References 25 publications

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Nanofibers Fabricated Using Triaxial Electrospinning as Zero Order Drug Delivery Systems

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

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